	   SnapGene      [acgcgtgtagtcttatgcaatactcttgtagtcttgcaacatggtaacgatgagttagcaacatgccttacaaggagagaaaaagcaccgtgcatgccgattggtggaagtaaggtggtacgatcgtgccttattaggaaggcaacagacgggtctgacatggattggacgaaccactgaattgccgcattgcagagatattgtatttaagtgcctagctcgatacaataaacgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacctgaaagcgaaagggaaaccagagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccactgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcctcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagattggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtATCGGTtaacttttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaattcaaaattttatcgatactagtcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctggtttagtgaaccgtcagatccgctagcgctaccggactcagatctcgaggccaccatgccctcagaccggcctttcaagcagcggcggagcttcgccgaccgctgtaaggaggtacagcagatccgcgaccagcaccccagcaaaatcccggtgatcatcgagcgctacaagggtgagaagcagctgcccgtcctggacaagaccaagtttttggtcccggaccatgtcaacatgagcgagttggtcaagatcatccggcgccgcctgcagctgaaccccacgcaggccttcttcctgctggtgaaccagcacagcatggtgagtgtgtccacgcccatcgcggacatctacgagcaggagaaagacgaggacggcttcctctatatggtctacgcctcccaggaaaccttcggcttcGGCGGTGGAGGAAGCggcggaggtggatctgaattcGCCACCATGAGCGAGCTGATTAAGGAGAACATGCACATGAAGCTGTACATGGAGGGCACCGTGGACAACCATCACTTCAAGTGCACATCCGAGGGCGAAGGCAAGCCCTACGAGGGCACCCAGACCATGAGAATCAAGGTGGTCGAGGGCGGCCCTCTCCCCTTCGCCTTCGACATCCTGGCTACTAGCTTCCTCTACGGCAGCAAGACCTTCATCAACCACACCCAGGGCATCCCCGACTTCTTCAAGCAGTCCTTCCCTGAGGGCTTCACATGGGAGAGAGTCACCACATACGAAGACGGGGGCGTGCTGACCGCTACCCAGGACACCAGCCTCCAGGACGGCTGCCTCATCTACAACGTCAAGATCAGAGGGGTGAACTTCACATCCAACGGCCCTGTGATGCAGAAGAAAACACTCGGCTGGGAGGCCTTCACCGAGACGCTGTACCCCGCTGACGGCGGCCTGGAAGGCAGAAACGACATGGCCCTGAAGCTCGTGGGCGGGAGCCATCTGATCGCAAACATCAAGACCACATATAGATCCAAGAAACCCGCTAAGAACCTCAAGATGCCTGGCGTCTACTATGTGGACTACAGACTGGAAAGAATCAAGGAGGCCAACAACGAGACCTACGTCGAGCAGCACGAGGTGGCAGTGGCCAGATACTGCGACCTCCCTAGCAAACTGGGGCACAAGCTTAATTAAGGATCCaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaagctgacgtcctttccatggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtctccgccttcgccctcagacgagtcggatctccctttggccgcctccccgcctggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaaaataagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggctctagctatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctagacttttgcagagacggcccaaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggcgccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgccaagctg  @·   $   -         (   -         #            *       #   &   '   )          *   ,                  '                %                                                 %            3   )         2      #   %      "   ,   #   %   '      *   (   3   %   #   $                4   +      +   /      '   ,   L   +         %   $                                  !         #   %            )                        $   #                     %         #   %   +   &             "   #                  "   %                  $               "                  #         #      "   "            -               !               %   (         $                                 $                  
               $   '       2       ,   -   &      !             $               4   "       !                     &   '      %   %   !            ,   '             &      )                         $ ûQR}~Ú%§!"#0ð{|Ã už¦§¨kØZJ\J- ¬½Sf«î½-K�{¨1ð‡ñ	/	q	a÷G-ŸØ©«Ù[X3¢ÚÑ – é 8C&$4
Äãl´"]9C* ü¢`°Ûö×]	„«Àá2V}Cvƒ³î cKâ-KÖã( I 	#.T¬­°³Æõ4L[ˆ=Í
	r	ß	õ	î
1=f�bøHµÆàìÚ÷ž- i ˆ �¾g€]r.Uÿ0Okuè»24"©P ¯‰ÝU¬f‹YŽ_£<ÃÛëÒ ¡ 
G„|ôÝòC$dÍK\>î4O[5 ¦ ­Öï¾Ž©ñˆ0	ª	L
d
ß
ú
�’¡�.pÙªób# f q 9Ê»n	
5
µ
Ç
.@ØÅÙç•mâˆ1GÁèÄµÑÚ:DƒÞ * t jx‘ Eþ%›\a	ø	@gd,A{Ñë&mš»û  ó rD'IÃäˆ	³	í÷<âIÄE„#^+ — ê u	^
|
ÛäŽ;—tRý*  öý aºØ^	e	Ü	Š
+:¬â~D�âMßï%>¤åa. ìLã®.@°×ü  Œ ï£Üí÷w%l–É 	…²Á3&ÜÚ„‚©¶àŠÇ]# Ü&Ý±ù@«þ
%W¥ó“w|µ´a˜ã²¡U= LPÂ& xÈ™~³¢c¹	Í	¦
åØû4¸âÎò$Wµ»ÄïÍ{†˜JdoºäJ' ôù$p®±»®¸>¥s	·	ö	ø
2>‚©¾ßTÁù¶×ÄÛ³¹ÞáíÝà$´¸) J L Â r/13>UL´Ç“ÎÐÒÔÚ8
ï
gÏceÂlÓÙÿÛA-ÝkørŸ 3 A
ö\‰q	w
Ê
gÇF;Õwà:•�«#Çót  
Æ@­v&5Mƒ	à	)
s
é
W[IÎüËP{(sÃ h¸1d* j ‰ ä+Ú^sÉV¼¸ÁÄÇ:
5u¯uæ#:¡°ÖVZB_~÷p`o¤eÄÓ, N �³¹¿h�…Ñ 1•Ñ3ñ
é*sª4¡ÆŠÆ,­gè�æ$=OìLr‰Ýˆ¡ÿ ² WÎ/òPv¿ÖàéPl¼7]IÑ®ËÈTßÜôA ª §³ì¢lÚð�	š
¸
iÈQÞkŒ­ % 0 5c…¾àˆ³wÔ• Ä Ý HNl¶ï6}ƒÞçe]ý?õþ%6 b ¢ · qéó`%8ÎÛ5CDi' y ý t] àõ™	±	
"
‚
D¼RlLŒÎ÷n¤ïúP\Å,Z\m‘Ú  “ § ÐouûÈÔýPY
	T	õ
û
x¢ú§ÚCÀÓ€×ú:G œ äðUg¿ƒ�¯ÖÜ?NM
à
Žú“/qŠïðcœæšç  d×ò‰é1	«	<ž¥</y«^œõ	ôõåÀ ø }®‡¨“ª¯ºÉ	ê	
R
e
É†aÄïròw.¿/ï% g r �ž+ý‹ ËÛo	/A‹ÙA›ÚàbÌàå“‡:ã_EHÂræ bÌjî¼Ž	 
6
¶
È
ÆÞ2\×Ü*yq²¾Å¶ÒÛ†  OQ`‹;2h	Ì
Î
èñ–ÁIKZ…(`‰¥ðévä;E„ Y } Ò CS:=—H+Ÿ�ê=Mn·§290…wvß
O   Lá+àø:F<b	‰F˜›Ùx‹+›¼ò± + m kƒã^œä]A	ñ	ebB‘Òì�­h¯zš!@ Ê Hž’!ÿ×4¤A{�¨´Qé-|'gn…üæE± u y^&)ByšÍj	ù	{hÞÉm  ]É(Xy
O´ÉÓ
€˜ÃW7�ž—ÞœÎÑ6^lõhñ=Î= 5 ô s¿Ís�îø2J…. ¼%Fx…$ ü	JU�Äå		‰	X
óä=!ã§ÅÍsÃ÷®Ì, <EÛž�)„’¶<Ó´Cs_ Š>	ÜË›H¨´�íôG ‡DË Sª	•	k
}
i·Ö�¤Ü<ëa£Õþ)35 	  ˜ ë Y�Öüv	’º0åS]Û˜Ê‘*ƒÃ G
_
Ð
JªÝêAFâuS% þ!O—Áâ_	Ú	Ý	Ý
,8;ãENÖÿ"Öà#*?/¿Cê37A[�á ·÷<a
u
Y­í&æ"Ã+!íMäØý  BÙf	�ã.Žçœ¥]¬¯Ê1˜ ¡çéb»¢	+
‹
Ô“ÔðbÆtájÇdÈ/±Æ3 ¿ ›Ó¨¼(ORd™œŸäx-&—Ê€	×	þ	=
”
£
ë
Gã'ÐÝƒ•ë°ücÕØãls‹"îf)  # 9 � ð¤.x“½ÌîÄÍøHW	
³VùÛýÁu€ªÑ MzÉ;ºÈÒÈ [ º ?ÃÝmÃ
4
!/YÀÅá“™^ª T ëŽûY=!	
¾
o†¡ÂÓì…©·Ž‡fx�2 áÞr«úE[¬…	î	@
—
²
]xƒ¦ô
j·÷jm}¤¶†™½ ¡u�¢Ã{¸eMÃùV '¯ô²T°ž	¤	-
Šz]‚åµhÍ}4V§Úí# '8EÝa7¨Aâ	ÿ
&
X	mˆ”6ÓÚ!2?îä ú7d©	¶Q% Ù Èç+=R#x¹b9•ò3³Ö!o–vž6>ðJø2ñ _ · ç	�
ZX¶¼R™4\eŸpÏ" yšé=º	OK¹ãHÆ“¹Î|‡ý
�X¸Ô¨y³ºõ&KQ, @  Ô -<ÉgJ§hÎ	�
§
ôš©ü‹u]a½%6[cþ'6¿ÅðgpJÈKá†å# U£´£³ÁFdtL	Â	C
Ö
·æÙ5Ïfó<Op|†‘œ¸»þ»%% «¼ú|ª¼¯z¦/ï3
ƒª¿à1UÂt¥²Y2bÙá![,Õ)' H ‡ Õ-	F\q¯²ô3T<ºô	í
ù
3e‘ ´ÅÜßeŠòaíNZÂ� p HÉt	÷	?×Øáz�%* ‹ õ%wÜ}¹ì?v²d	¸	¥
±ú%·Ù�´ºâîÞ=z…—±-µßÆ­¹¯Á( K Á qÅó02?Kou%’pÏÑÓÙ‚	dfÀkÒÔÚ²þÜß9”ªcs3 M *V„²ÐÙÈ¡ñ”¾ÐÕßOÀÃÆ6\9
ð
hÐåè)r~­ ÅÕSj^åöndÞ$Kˆ % Ã ü s4\Mkµpîß˜	°	 
�
»k‡æ7‹ÍömüÚùB[ôC²lh”# ’ ÷ |ãTf†§‚’ÕÛ>MÈ	Q
ô
Èw`¤ÃBqñvô ï.ù$ Ñ BNŠ�Ë*–Šií*1�	Ë
žß<H„ÖÛ_xD±quã/vuN  l KG�*‚ßâ÷]9;ã(Ax™ÌE—š³Øf„Ž¬°gÈ 4 ¾WûTr	W
x
È�6€ƒ;„–rŸÝ³»Â$kôr   †Õ‰©ûIhG€§Ûá�Ô4 ¶æ AN–á¡	Ù	*
t
7Xþ)\!¾ÂiB«264 8 S š§-w’ú'NQX›žÂãÌG	Ö	ý	

<
½
Â
ê
FÏÒø”	 XtÄÔ×L�!˜¹e+ Ø 7Ç®ó`6æ§„	á	?
–
\w	<"£…1ígÌ|¼2nœ�¦
IðøU ,f¶™J’ý&Qfº	€W[$+ G o Š »,vÛE[¹Èó	2
d°Ö$³€¤±<y„–`ì1MaYÅØàœÔ/ òƒSjt…
$ð½ÏÔÞNÂÅ5[P
€
ó
vºç_q}†¬6pŸÌÄiûî“õø±‡ k Ð J�ÊÞú0@úV
�D×^ÚCqƒp¯fjÓ.u' R +6µåM¦_•Wâ¦~	Õ	;
6vµE;¢%0We[›Ó¥A#T, Q 5´º‚DR€Ý	#Ó4Zò
«5ž£/Ã]d;hxƒ•ú’ëL‚@-×t L O P ‘ijk†‡ˆ”Qzåæ !"2ÆÒ'deqx&	9	
ê+�¢Ç‹w‚“”ÌÍ�‘çèéê%JKjk=>?,>P¼½ÊÔÕÖMNs§¨Þ¢B+ ’l‰�ç×çc–ò(jryž_'	:	Y	
,¬ÈŒÇý	-ÎelxËíOW©‰£ å À•Ò{3ÇUfë+XtûE®é¬°&‘R?Q¾SŠßC lQ×ó3ŸÑV`Ô	;	Z	rvÈôNtÅm¦"ÌîB%  â 2Šè%Ø0`¬Qm½8DÎìÉ,ÌþDO¿àÝõPXªŠ¤$ ³ Xm�ÂÏè†¦—ž¸áê)^kszJ-�¸ 
.?Šf˜— “ÂódwÀ(	
Ò¯­ù�ÉUÏy}­ - æ ´ñ·æ,	´Õ,¿ÝÃÑ`!Ë@#D % ; � ¨–Ó|£¿m›ÛJgC	n
jìY¼Il­¿T  mÎ4V”F	ÉüIRg¼ßFv€ÔO'’ø|&R�UÊ « Áù0íÈŸ‘	›
¹
‘'u€ÿ¯�ê®æ±SÏ|‹ à ( Ÿ 6d ^†ô a…¹Õ	[	Å

_2‘³õ–þ‚ˆ 1 ¹mØ4ÒW}q
UsÍÂwÉuÆ?n‹#*/˜Õ Ù<	i
™M`¢O[o)4xïC  > ] R;r¿À	má‰s€®§¦´èÍìY– ›Im1”7Rgn¾9Eáíßi¯lÛÀáY«! ã 3�#OÕÛað%1B’Ï|	ªÊ-ºòÿ[^øöP•ÞQ¥ Å ‹™!·ÓÙ#~9z	gÍ‡‰;}  Þ é&­Q„qèfLEþ@ÿ&	öü7‹¥# c £ ´ ¼ Ç 8ÃéŠµr¹åÅúM	Q	9…Eè/‹ë™×9'j% „ JY‘Ðñ‡˜Ÿâë*‡ê_lo¦³a&¬‡ÂÜDg•�’�ð Ì §!9{ô.š¶#¡ªi6ÎE=Gj n¸-€åtKCŽÏ¹¯1ŠÐ@˜Ø¶½ z ^ÁŠ€­&
Ú
SWÊÐØúã[Û) ÖAßx-6Ñ)	#
ƒ
•Ó$½\°}ÏKX/VÇGz®I{6•³`¬ þ ”¡Åeöž²	ã
E®NM�ÏøŽ§S~pðQ~½Æ]’› uÃýôáš	

†
¥ý6Ñm®úok5MÍ¥û]×‚Œ-«n ” ç ívòü™Zî-	l	ü
y£ÖKGSéØûH . w ¨ µ}¸ç
ö
¼s-ÀÕDÄNÁ«ó"ü¶8E ÉÕþQ¢	µÉÞ¨Ûè,ÌA�;   ÑpçDU	¡
Ô
[hûÒaÔsß4îó$ � ©ñ(�{ÀÓn�°×Ý(Kû	À
¢rQð7d�ÝÀ’$ E à å÷h}À„¤œ¤ÜSbhoD	0
N
�²½)‹~û=GÊ®U!# & < � —Ô@O�+{œÏo
á
kq}£û]oÏ0ZeJ…m(9h›ê V{¢¯+”íEñYçè ¯ $ë�B¦êý=î‡¬à,™ � ÁŽoË n[W†–ŸJh�õÕP[ùV `	•ó!Š’2	˜=Ê0z–½àöö“}'¢  eØÏ5±êG	¬	ïS½_Gw�
7(æ~ËS�øþ V ‹°’	§	Ê	ë	ˆ‡Ž;Àµ(:ðb�§% ¬ ù ÂúXˆî?É„¶#	½		
S
f
º
R’Ê(l–bsó ²£TÐ¨Œz ¯©€˜€�ÅðÉj°BˆW¹|¡á  ~1ý” «»	
œ
Ä-�v xë/¯ç0}‰# 7e¡í,BJ_Ù$Œõ †Ö	\	p	`öBÿ‚âjíŸ³Ð% h   ¥ Ž¬Åþ/NZjtƒ‡çÌ	ÜK
0B€Œ!œ¨#coÌ®ˆë;+ ) e s ò i�Dº‡	]
{
´
Æ
Ú?²æ”fìcö;Fl™ºÃ:–sçúƒÃ& ŸÇø¡ª$bk•È	3ŽÛá’Íá´V`—£ä`Iÿn‰?Oû  2 @	º­·7
r
É
VÎSÃû:ØÊÝvzrß@Œ³ÆÜj·0q ± ²ãÍë»Ùkï�	™
·
HtÇ93Ê+ÇA}oó@Ü‡ Ÿ5½!
_ßQ£$+�Ó" › cnt®ÇÓüOX~è		S	…;ù‰¦x]›¿›ä¿™Öæ# PR_aŒ:<üGÿÍ
Ýš1aËéðÀJLY[†9')p¤¦8½…	   É à]3i	ð	zz§ˆÝPawŠ*ñåyDl? \Ì;ÈÚ	Nò—ÂVã 1(Ì›Ð5wgð<Í Œ=	j
Ï
¹Õš£@\³EÉê`¢)F ;ÀìÓ!�’æ"ÅsÆéZ€—Åà  " Z ¾ >˜Ë<,“
n âëÀê.¯û¿¨Ðy:’†íw" &Dàª*DSZ±
‚Ql�‡¶öl¸äÒÙ > 3z¨Ùµ÷1% ? ^ ~ ¶ Ó ;TI<sÁ	B
¨ŠtG`eÅ5No›¸3àžÓ§ýÎxP † ó2;Guîc	°yŒ,Z¬ ö p)[±ÏâJenío¿=jŠðjó]Zó©J   M…œá•V8Shì:ˆâ¨Œ	G™œ5ÚÜ²Áâ 7 × ™,ùFà 	÷‘“fmœ½H  n Ï *Lu„M}	ò	c|oË$í0®i°ß†›$ ä 4Ž“PÖÜä
bñ&Y�^«œ. \c’ùdiw��Q+R¦A Á$_«·2CÐq·óŸs‰ÄC¬—¾– , lš“åB	Hf»u_ÓN÷{ŸT"  Ÿ¸]Ø:q„	˜L_�Á­(Šý‡çX~ Œš "ÒÔÚ“"$fy	{	h©¹ñ÷†ˆ¤" ƒ Æ Ë I7‰´ä,L¥²B„D«®µç©ÏêhÍ”&<F‘ï ‰ 5|ÎRWj4.L}Ì×ùoF¼H�z”² v ˜C¡k	æ
»rÈZgçMFRÞû 
ò D ß ö'z¡®'Ran�*z›Îú	/
|±¡(}ú6XÜ'8  ê_…‘•éßŸÊ¡÷ýn µ¦	Œiÿ:A‡¢'aŒ¦# d ¤ ÄAI#MYsæC#”Ç	\
z
�Uêìk˜9•ùm:>Ï ?ê¶ºÆûNç	R	:9Þ@¢ iò?  È ^9:‹þ	0y¦ÊÔ™ÜXâ8?0ËšÏ7_(k># ! µ ½ :ß©Ê);YP†µõFdÄØ4¿éúŒ‘åŸÏß�ÅÒØöü 6 … õ „ZÎdòìtë§‹	�ï~GI" Î )Kt’À™ª¶LbGpn›#ˆÃ/chv«–½*žS"  ‚ Ñˆã+ˆ~pƒÀª­¸æðV¨¬3KËøEG€y†%�“ C  `mŽ—´'Y|ù9†Ý¡&ž` ñ 9¨":ýXÆæ		[
/xôT×>éùäjÊÎÿ8Äø> Í ƒc
K}Š	Xo¿mš}·å§«buF)ŸH- ‚VW|Å	Y
Z
W›˜™ÕÖ|$%&'¢£¤¥¦æçèø¨©ÆÇÈÉ7at¸ž- bŽõŒõ4	Ñ	–œ(28®("¢ªMfÏ¹¤¯k¿Í. o¹æä	"(Lñ÷3ï9U…“‹ÐµOGtÀÎ·ê G¤.��uÒ	š!BZÌÿ—ºAŸ°)·TÔ•¥	¾ Fcª
?D�Ðá2‹Ng=™ºÙD°! =Üö�ö5	­
NŠ)9�¯
*‚Ñ#A£öü«	*`l/ Úp#)ñzœðIÂ©ËV†ŒPHÏHÜ Û Îçù�µ	'
ÝøÌÑu { ‹‹?	?µ�ÙÑîäòõ\ƒÁ _ºÂ®å	Û
MòT4X»: ”û¶Æ¸ë% zˆE×¥�–	®	Æ	¾× @t‚±Ð0WÝ�¸¯ÀJb–*4a­¿( 0HBjàvÌ.TÒ	*	Ó	l
~
›Ô%C¸]„±÷*BL9ØóH{ÍW
 7/7«$
„
"¬~˜U ¥IYj=Õ€¤Ö47ú-– Ñy‚ì–[jÍ »*;ƒ—5Èq*U8ì|¦´ÿ6$ ™ ð ÿ ZgŽÆ×-hFO!ÑâÐêù
Ta^Èqx™Ç»Ú±ä	 —5dŸw	ä
¯“‘3d	Ë’„ 
   ¢G«
@E½(Ž¨TôÜ> RœúE^“œ è ì î •ÊÌf÷ý³	êž»1Næè�Œ#Ohñ¾šU+Ä I	›	
‡
¦*�+3yƒŽ6÷µ+GÎ¦ƒW¬a éâ÷÷ÿ6	Ñ
�Òn°ûBÒB¤N¬˜ãØ@‰�o Ä>õ³ŽH
®
þKT £¯%«Þ$ý%ü^vLT vþ›Ý
`
ì7Oó‹:@ëP^¿pl
Qè.mó0 • è Pï.	zF,�×ª×W¡I8BIâ "ó©	Þ	c
Þ
<O JT=�^ê4ö qwýš[Âã`	m	
-á+@H‡Ðê0ÀDQÐÙü‚Ý$ Ûîÿ˜Ì	Û	‰
ý
$*9ä¤×òL{ñ#ÃÌ$T¨<ë\I ø=¤¶	(
v
è
÷
Z¨½ÞÁÍÖE¸O'Â#,g"ò· © ¦¸·®tÅç¬#Nqþ / a x Ü b¶è‚ÄýYvÙ Ï~®ú¹é	
ù;.îÒî-¾ôîå9F  X | Úg	Š€@ßä’¶^ïå„
 Ö£@	Žè�®°™ ŒŒÒ��¦‘µ-ÒÍö]B­Ë< XCÊÿR	”	F
¶‘Ê©Üé/RÚìó‚Â(2  è`
Ü
Õ-ÓÕ›à*cÇÉ0 ¹ Òê»�c¼ÃV	¢
UübâkÈrÑe�©Ç$ q¯�	£	í	,
‰	y\i5i8”ŸñùÕ 6ct•Âu·5ïdì' ¢¦²ÀèEgK	æ	Œ
�
Õ
NóY\¼5;Zbo{…�¾·IÇü…·²¹ô%  ªÔ{©S|ëy±.¤
ì
0�ŸØsXd‰ñÞÁ +®À(2 ‘ À û {ÄØ¦� o‘‘ØÞL�	—	¯	Ç	ÿ	Ç¿ä(£åAõuÑ±ÔýRÞ8ÙäBmc#bg“  ‰œF½))Ô)'w˜ËHÞƒ–²¦‚eƒž°�ºtq3M, ò‘Peš�ÁåËØ	ü	

>
•
¼
Á
˜Ñ!ý„ì»1~¹ÖÁKVZ	Œ—ªï5÷- F Iñ¥Zi”áï¥ÎÝù/?ùÔ	1
O
U

œ´ÕD¹^p…²CÙšÒôÒX"S& æCy~ÅTcipw%	8	X	
Wú*ÂüD:v�Ë«¯I<»ÉÓV  á 1Ák…¥�ÍëUÓ	Œøu+M>|¥!N! $ : Ž ø/¾ÍžI¶+	E	m
�&³Ô»¾ÜþÂHÐå{ÊÎŒÉ  ' = \ ž |¸¿	h
p
Ä
Tlr~Ì^1²¡Z•n>)3�¥.—ë ˜0AP‘à8pfKZ®kÚ”û:| » ð8†äÄùn	P	™"0‰†ÁÖ×8iŽœµ¼$ Õü@ÄÞ,�¬Ð%
…
Ù
â
”¤ü#5­ÐM[V¦JÆÖ‹âª5š_« ì|í 
Ó
ÔJrªò+3íèµ7 �Òz£¿
p¢*\nÎd<DF„PÉgé ‘ ® #œZA° —îí†•¼+˜6ÿZ}�€ U WŠü >ƒ—	"	¼	
Q‡Ã,k•È´V¸9ˆ§{y4 ñ hÆì«�Ø÷.i‚©j†	J
³
 õ �§þ">±nËe­áë b_i¢ž¹Â²Nú" š °  ±âžs¬­˜
G^R„8Pøˆ¥úšÉ¾|šãÛ�~åp  [ËßÇûF\ï	yÜ¸ï~¿‡U&²'Dv£È¡¼f
Ì! %CA
’
°
§ëk_k·Òã Ñ-š¾!2Äryx‘Ä Ö o˜(°U‡Ÿ	öi’4eò\Y¨ 	X{¶tžr~M€… 6\³eK±x	—K^ƒCiÎöÖ»Ì“£Wî õ� ¥	.
å
º‹°” Çæ5QW
úÛ    9>Þ@HLB"“¥cÛ38¾áÝ?¡”û  B � (©µ–‚
F{�"©ïU8Ê÷ª
�_R& �b8a
ô‹3	Ð	Vnw•¾'17­Sl—Ô{å÷¡Leþ`~·(�£¾' F£ã	©
¬
 !'™ðö >AMYËþ‰àî	)8@õûTŠSNF”é Ú ÍÙø´	ð>yºÁÿñ‚Å% /yiÐ6ë­	Å	«ƒTö?)sH:‚–48×ip€ò)¿7Ì3Vù,%  í ï f–ÉË4,gé ¼'çé	`�cÇó"wŸ›ùTÿãç! è²šþH	ëœòSŸ¢$?2O]¾x�´$P—ç?ˆKVò ¨	Ë	
b
ˆ
+S<Ïé§;]  õ ` ¥£­¶è	§:·í,½fXñp W W“	E
‰�Ñ‘Q�´ë­', ¸ Œ¥±¿fJ	œ	ì	
Ž
ˆx[h,4Yanz„�½7žøš¶5HÁ¶)„qcÐbŽ¨' ú Ãz€êÊv


»
Æ/�—žäüô~Ó¥º}ˆ‚AUYŽ¹p©ö'2L Y�µê>ø$	7	T
ÓoºtÁCÏ™ä¤Ñ‹R ûï…ãÃßø·	O	¾	g
Ø
S“ËL±ˆ”­ÙŠÕ2©�{´»  ­ "‰›ÿ@– 	»	Ÿ
Ò
P)mcIÇ”COþ³2z& °ÅÊªö�¨iI
‘
¯
ÿQÛ7Œ°^¾Êdÿ%h±½&1Câw} Õ J�¹ÆõBsñqLXº¢) A € =€ ?K´�Ï	¨
 ïõLýUv¤&b¬ßí7Rk7zKSÉ‰ý_M½ .x3h™Ä	è›ª‚ñ¡>õ&>\(rÀÆþ‡Uâæ V¤¢¬µ¤¾e
D
a
9wŒÐg`Pm�ì³¼èêÿoô&  !þ•œ´ÂÞu	N	
ž
×
Å.ŽÀ}‡“11~Š1 wÿ2IÃ	¸çîPÚ6ô=Aìô=Qqyr¼0R¼  ¡¼½GH	M	
�
í8;<_q’¹º»°±²é/0n  /
  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                        '                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     	                                                       	                                                                                                                                                                                                                                                                                                                                        
                          	             	                                             
       2   #   
         
      	                                 
                        	   
            	                        ,   %      +         '   &          …   a         $      '   "   `                                                                                                                                                                   '                                                                                                                                                                                                                                                                                                     	                     	                                                                                                                      
          	     	               
   2 # 
   
  	           
        	 
    	        , %  +   ' &    … a   $  ' " `   {Ä  |º  |Ê  }  �V  †„  �>Ó Ô` ¤ªöÄ	ì	�
¸)Ñg¬�Ï}�5LôåAÈÁåe
h=dt îz¿£d¼\º|Ä¹q=ÚÃxª<çŽY²ÃÄ£=dÁÙÎ	‹
oã]a½%6¶¼üg“ç*œØ\xª±ºØT
Ó6EÌ0qå/ååA¸lâ�èdˆ k»i ]õ±	~
¸ ]Q««òs¬¨¹ªèœ
ý D¼÷–	®	OIW¨÷ P‘.H
`
�*óH
�¬¨¸ð¥
úîÈýP
	§Ú€á<’ÆÅgÈ  	Š
…Ágm¶°7(1Ë@˜áVÌnIlryI,	â8|£” ÈýP
	Š
�§Ú€°¡	*
("  m†
ÆŸê§0…vŸê§…v¢´	‡Â•ž	S„ŸÀêƒM§…vá
Æv€Ôµ>‚ Š
°u[ d>5!
ëýàu}1ße’
 ‡v5Û ¡	*
Š
ïa°ü °	‹Íö ¬¨© 	^
Š
…ÁHgm‹²¶=^°«èœ?>8Ýƒ×òVx YÙê äÂ-¡zY?K£·‰§./ŽI‘±ÿ”·Àh'P/§	;Î » ÖÊ	:ç®±ÄÞŸ
ô�—+x é	¾YîÙ/Âÿø·±”_
SÆ„ŸÀêvƒM§0…vz=-–mY?K·±”'óÿçs[ 8Ýç¤“£dž	�
£
Y³]f¹2œ¹&|¡ÑXMáõù·‰I‘±”< [ kmê¡ü sßô˜	°	 
CkK‹ÍömîùO[[la¬Ù
V›(Ýs#A+˜�šbu)Ü	:MI	3yƒŽµGƒ
Æâ«8|£èœ?”Pš�ü	ÖC°
kyI8|k
6_¦0áî<h	Ž	k
¶
Ð
‹ŸÆ’›ê§�…vÌ_-h÷³	~
¸]„!Ò©VÜ> ó=@-–´6Á  Ò+ãXHØ	ì	>
•
hý„»Á¶c5÷¶eÙðyÁ´	’
>
•
„»÷(>´	ƒ"8×ÝòVïüÃ,ˆP7³](x™ÌzÝÈl‘ò ìöƒ
ôCKîO[tà™	
ln¤ú\,mzÅªêö�¨iI
ÿ/�žŒ°Êdÿhˆ'ë üº0å*ÃÔÚÂÿ-øOd™œä×	=
@
”
¦Ðjj¶ƒë½ ÃÕ‹îÃ­©³¢c^
d
åØ4ÎòctRºã
a
+è ÿô»
5
µ
Ç
ÅÄµÑÚ‚j U8¦­©^
d
tROd™œä×	=
”
ÐƒëÕ‹î@
¦jj¶½ ÃÃûØ
“LŠ©5c…íü
£ÖKSH· þ—Od™œä×	Ú	=
@
�
”
8ã¦ÐjZj¶"Xƒë¼½ #™4ÃÕp‹êÏî[ÃzÅªêö�¨i
I
a
ÿ/�žŒ°+Êdÿhˆè ÿô'?ÃÝ4
Åá™^ª¾àˆ³•ë¦ý=¬à Áv~¥‚Ž¹p2L„ü…
¤ü5ÐÖ‹ªy­	Å	?s€¿ ¬RúÉÛp¬î½�¨ð‡/	-Ø©_
êV (vÓü(™Zl	’	ˆîGŽd� ØûË y¬­	Å	R{?�úsÉ€¿Û…p‰œ))Þƒ°tM® #œAí†+˜ÿ�ÐoT	úÓYB�.1¤¾ewg`m�OEÖÖ7Aád×·òv¿é«	Ñg®ÎF^È	TàåÏúÊÒìó9F™ ÿ z×¥�–	®	Æ	F¦¾O@IùtÐÈÝ+Œ™WbÚäa ¨
 ïõLýßí7S‰M‰ +Ú¸Ç¯#°_`ÄÓ+ bk�äA	i\eøÒ… ë%¾zþ!5s¼ÁÄuæ÷¢«
@(ôRE“ ègFàd×é«	^	åbi\ë¾þ5·òv¿Ñ®ÎÈT· þ—Ú	�
8ãZ"X¼#™4pêÏ[® #‰œœ)A)Þí†ƒ+˜ÿ°t�MØsÉÆn.!—ŸÔòé�¬ è`
Ü
Õ-ÓÕ›à*cÇÉ0¸ Œ¥±¿fJ	œ	ì	
Ž
ˆx[h,4Yanz„�½7žøš¶5HÁ¶)„qcÐbŽ¨þ!O—Áâ_	Ú	Ý	Ý
,8;ãENÖÿ"Öà#*?/¿Cê37A[�áu y^&)ByšÍj	ù	{hÞÉmØ 7Ç®ó`6æ§„	á	?
–
\w	<"£…1ígÌ|¼2nœ�¦
IðøU¡çéb»¢	+
‹
Ô“ÔðbÆtájÇdÈ/±ÆÖ o˜(°U‡Ÿ	öi’4eò\Y¨y ý t] àõ™	±	
"
‚
D¼RlLŒÎ÷n¤ïúP\Å,Z\m‘ÚxÈ™~³¢c¹	Í	¦
åØû4¸âÎò$Wµ»ÄïÍ{†˜JdoºäJ¨	Ë	
b
ˆ
+S<Ïé§;]  õ' = \ ž |¸¿	h
p
Ä
Tlr~Ì^1²¡Z•n>)3�¥.—ëØ ,7ÇÜ&x®ÈÝó`™6f~±æù§@³¢«c„	¹	Í	á	?
–
¦
þ
%\w¶å	W™¥Øóû4<J¸â“Î"w|£µò$W…’´ý&1íag˜µ»ÄÌãïQf|¼Í2{†˜²nœ¡º	JU€�=W[d¦ 
Ioºð$LPÂäøJU ' = \ ž Œ˜šŸ "¸ÒÔÚ]“"$0fAP‘Øà8:q|„¸y	{	¿	h
p
Ä
	Tlr~Ì^p1fh˜L_�©Á²¡¹ñZ•­KZn®÷k(>†ˆŠÚý)3�‡”¥çû.:—¤ëX|~ÉÕþQ¢	µÉÞ¨Ûè,ÌA�; " Z ¾ >˜Ë<,“
n âëÀê.¯û¿¨Ðy:’†íw³ Xm�ÂÏè†¦—ž¸áê)^kszJ-�¸ 
.?Šf˜—.x3h™Ä	è›ª‚ñ¡>õ&>\(rÀÆþ‡Uâæôù$p®±»®¸>¥s	·	ö	ø
2>‚©¾ßTÁù¶×ÄÛ³¹ÞáíÝà$´¸Î )Kt’À™ª¶LbGpn›#ˆÃ/chv«–½*žSp Ø 7¯Ç®ó`©6æ€§H˜ÉÉÕþQ€¢	t	„	á	÷	?
–
?\w×	µ<�ÅÉØðÞ"£¨ÉÛèj…1ígÌ|°¼2áBnz�œ%ˆ�,W¹¦Ì
IA|�¡áðø;UÛ Îçù�µ	'
ÝøÌÑu  2ç   %  ‡  T        Ts"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìF?´|>­M0Á:Ï8”�4o1ôßôÕoÂlLçP!Ó�ËàuRªð}‹]„Ä µoóãNýÍ®¾8!}7M‚"÷?lÁÛœMTq¾æ`¹Ï¿A_¬:ÃS�¸ZÏ}„Äá¥]�ØS‰Ø7È}·­HÝ¼@ÅOç7ô}„[P‚Ä?»þ³ë¾y:ûœ4Ô~¶×Ýýoñë­M/¯á­ØD·ÝœQÀŽ9ý}>ô8ûnuËQ´@!zÝ½pþ!�UÞÃ€Cë|G8Ÿó‡>Ç`þì€ÀOn5vÔ}Ù‘½E9EûQ�ƒ.yˆtxÔõ×ùËMÄ ÒFxÇïäÕàÔéiA½m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           $  4  H    S        ®ZTR

BASE       —  xÁA�AÄÀ£6êGX–&�üu©¶\.5Å¡‹D¥iê"�P#ÈŒ‰¬¦Ëm¶Ð4­˜8gÉ
#×*kEI«e�¼û~ï± ±¹I›SÖ
 ÉµB%Í5(jHÓ%Q%¦Öb2#sÕ"Hr©MW¡Ð¶­¦Êš ‹Œ¶š“i™¦Kr�*&¥››.W”D’Õ¢µ¦˜ÊÌBæ0’" ŒÂrÓ9ÆjÓ© ›åæâÞÝ{÷îûî¾ßûÝ»ï÷îýÞ»ûÝ{ï~ï»ßÝ½ï¾{÷¾÷ýÞ½÷¾÷Ýï½÷î»ï»ßïîîî»»û½»÷}¿ß}ß»»LxûŒ   ¹<AlignableSequences trimStringency="Medium"><Sequence name="pLV3-CMV-mCherry-EGFP-MAP1LC3A(human)-Puro  (3620 .. 4281)" ID="0" sortOrder="0" trimmedRange="0..661"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $2<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3597" maxFusedRunOn="3597"><Segment range="2854-2868" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3597" maxFusedRunOn="3597"><Segment range="2869-2883" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="MAP1LC3A" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3597" maxFusedRunOn="3597"><Segment range="2491-2853" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;MAP1LC3A&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Atg8 family member found on autophagosomes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human LC3 protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="TagBFP" directionality="1" translationMW="26282.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2896-3597" color="#3366ff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric blue fluorescent protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6835" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6044-6835" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6836-6904" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5285-5873" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3604-4191" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4265-4498" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4710-4845" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4570-4691" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6905-7009" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="4931-4937" color="#ffffff" type="standard"/><Segment range="4938-4955" color="#ffffff" type="standard"/><Segment name="-35" range="4956-4961" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4976-4997" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4907-4923" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.53" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4074" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="3691" maxFusedRunOn="3691" visible="0" detectionMode="exactProteinMatch"><Segment range="4075-4086" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  =<Notes>
<UUID>8f0e048e-117e-4684-b528-ea21b2f9a9c2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="7:21:1">2024.9.5</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  5<StrandColors><TopStrand><ColorRange range="0..2489" colors="black"/><ColorRange range="2490..2528" colors="light blue"/><ColorRange range="2529..2852" colors="black"/><ColorRange range="2853..2882" colors="light blue"/><ColorRange range="2883..7507" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2489" colors="black"/><ColorRange range="2490..2528" colors="light blue"/><ColorRange range="2529..2852" colors="black"/><ColorRange range="2853..2882" colors="light blue"/><ColorRange range="2883..7507" colors="black"/></BottomStrand></StrandColors>  -   $  x  6        6s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìF?´|>­M0Á:Ï8”�4o1ôßôÕoÂlLçP!Ó�ËàuRªð}‹]„Ä µoóãNýÍ®¾8!}7M‚"÷?lÁÛœMTq¾æ`¹Ï¿A_¬:Å¬÷ØLNPEØÝ…8��|�×ÛzÔ�ÛÄPÔþqGØEµ,@Ãû¿ë>±Ûàç“¯¹ÃMGëm}ßÐ6ÿºÔÒúþ:Ý€DK}ÙÅ ÈáóŸÐwÓïAÃ�¶ç\µD­Û×âÑE]ì8>·Äs‰ÿ8pÃàPÑ\váNÈöá³WmGÝ™ÔWó”_µø2ç˜�çG�QmA]qœ±4ÜB ôgŒ~þM^ ÝN–”Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           *  õ  5   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  !œ<?xml version="1.0"?><Features recycledIDs="19" nextValidID="20"><Feature recentID="18" name="LC3A" directionality="1" translationMW="14272.49" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3567" maxFusedRunOn="3567"><Segment range="2491-2853" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;MAP1LC3A&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Atg8 family member found on autophagosomes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human LC3 protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="TagBFP" directionality="1" translationMW="26282.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2866-3567" color="#3366ff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric blue fluorescent protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6805" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6014-6805" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6806-6874" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5255-5843" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3574-4161" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4235-4468" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4680-4815" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4540-4661" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6875-6979" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="4901-4907" color="#ffffff" type="standard"/><Segment range="4908-4925" color="#ffffff" type="standard"/><Segment name="-35" range="4926-4931" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4946-4967" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4877-4893" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.53" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4044" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="3661" maxFusedRunOn="3661" visible="0" detectionMode="exactProteinMatch"><Segment range="4045-4056" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>8f0e048e-117e-4684-b528-ea21b2f9a9c2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="7:18:38">2024.9.5</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..7477" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..7477" colors="black"/></BottomStrand></StrandColors>  *   #  4  ç        çs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½,}k=ö†”v7aN'`@ß uöÞµ#vñ5?œ@ßÑömB0þïúÏ¬vø9äëîpÓQúÛ_wô¿Ç®µ4¾¿„·`ßvqG 28|çôôûÐpãí¹×-FÑ …ëvõÃø†4QW{­ñâÎ0ø4WƒøS²=¸lÕÛQ÷fFõüåíF>¹æ yÑàT[PC×\Gç,M7ƒH=ã¿“W€7S¥¥õµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           	Ã  	Ì  	Ò  	Ö  	Û  ¦  æ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  á<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="TagBFP" directionality="1" translationMW="26282.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2531-3232" color="#3366ff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric blue fluorescent protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6470" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5679-6470" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6471-6539" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4920-5508" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3239-3826" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3900-4133" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4345-4480" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4205-4326" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6540-6644" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="4566-4572" color="#ffffff" type="standard"/><Segment range="4573-4590" color="#ffffff" type="standard"/><Segment name="-35" range="4591-4596" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4611-4632" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4542-4558" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3709" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="3326" maxFusedRunOn="3326" visible="0" detectionMode="exactProteinMatch"><Segment range="3710-3721" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>8f0e048e-117e-4684-b528-ea21b2f9a9c2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="7:16:37">2024.9.5</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..7142" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..7142" colors="black"/></BottomStrand></StrandColors>  &û   "  …  )        )s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½,}k�°o[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            	Ã  	Ì  	Ò  	Ö  	ß  	è  (  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ´<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5768" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4977-5768" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5769-5837" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4218-4806" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2537-3124" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3198-3431" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-3778" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3503-3624" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5838-5942" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3864-3870" color="#ffffff" type="standard"/><Segment range="3871-3888" color="#ffffff" type="standard"/><Segment name="-35" range="3889-3894" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3909-3930" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3840-3856" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3007" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2624" maxFusedRunOn="2624" visible="0" detectionMode="exactProteinMatch"><Segment range="3008-3019" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:23:44">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6440" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6440" colors="black"/></BottomStrand></StrandColors>  &ù   !  „  (        (s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½,tE®6Á½m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           	Ã  	Ì  	Ñ  	Õ  	Þ  	ç  '  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ´<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3006" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2623" maxFusedRunOn="2623" visible="0" detectionMode="exactProteinMatch"><Segment range="3007-3018" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3839-3855" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3908-3929" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3863-3869" color="#ffffff" type="standard"/><Segment range="3870-3887" color="#ffffff" type="standard"/><Segment name="-35" range="3888-3893" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5837-5941" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3502-3623" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3642-3777" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3197-3430" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2536-3123" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4217-4805" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5767" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4976-5767" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5768-5836" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:14:9">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6439" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6439" colors="black"/></BottomStrand></StrandColors>  &ü      †  /        /s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½,tK‘¸Ûõµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           	Ã  	Ì  	Ñ  	Ü  	å  	î  .  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ´<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3013" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2630" maxFusedRunOn="2630" visible="0" detectionMode="exactProteinMatch"><Segment range="3014-3025" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3846-3862" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3915-3936" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3870-3876" color="#ffffff" type="standard"/><Segment range="3877-3894" color="#ffffff" type="standard"/><Segment name="-35" range="3895-3900" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5844-5948" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3509-3630" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3649-3784" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3204-3437" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2543-3130" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4224-4812" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5774" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4983-5774" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5775-5843" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:13:59">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6446" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6446" colors="black"/></BottomStrand></StrandColors>  (q     |  (        (s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½äE®6Á½m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           	Ã  	Õ  	Þ  	ç  '  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  m<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2501-2517" color="#ccffcc" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5767" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4976-5767" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5768-5836" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4217-4805" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2536-3123" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3197-3430" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3642-3777" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3502-3623" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5837-5941" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3863-3869" color="#ffffff" type="standard"/><Segment range="3870-3887" color="#ffffff" type="standard"/><Segment name="-35" range="3888-3893" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3908-3929" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3839-3855" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3006" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2623" maxFusedRunOn="2623" visible="0" detectionMode="exactProteinMatch"><Segment range="3007-3018" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:11:30">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2522" colors="black"/><ColorRange range="2523..2534" colors="light blue"/><ColorRange range="2535..6439" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2522" colors="black"/><ColorRange range="2523..2534" colors="light blue"/><ColorRange range="2535..6439" colors="black"/></BottomStrand></StrandColors>  (s     ~  /        /s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½äE®4±Ûõµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           	Ã  	Õ  	ä  	î  .  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  m<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2501-2517" color="#ccffcc" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5774" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4983-5774" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5775-5843" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4224-4812" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2543-3130" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3204-3437" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3649-3784" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3509-3630" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5844-5948" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3870-3876" color="#ffffff" type="standard"/><Segment range="3877-3894" color="#ffffff" type="standard"/><Segment name="-35" range="3895-3900" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3915-3936" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3846-3862" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3013" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2630" maxFusedRunOn="2630" visible="0" detectionMode="exactProteinMatch"><Segment range="3014-3025" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:11:22">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2522" colors="black"/><ColorRange range="2523..2541" colors="light blue"/><ColorRange range="2542..6446" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2522" colors="black"/><ColorRange range="2523..2541" colors="light blue"/><ColorRange range="2542..6446" colors="black"/></BottomStrand></StrandColors>  (t     €  5        5s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½ä@üZãK°o[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            	Ã  	Û  	ê  	ô  4  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  m<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2501-2523" color="#ccffcc" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5780" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4989-5780" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5781-5849" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4230-4818" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2549-3136" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3210-3443" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3655-3790" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3515-3636" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5850-5954" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3876-3882" color="#ffffff" type="standard"/><Segment range="3883-3900" color="#ffffff" type="standard"/><Segment name="-35" range="3901-3906" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3921-3942" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3852-3868" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3019" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2636" maxFusedRunOn="2636" visible="0" detectionMode="exactProteinMatch"><Segment range="3020-3031" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:11:8">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2528" colors="black"/><ColorRange range="2529..2547" colors="light blue"/><ColorRange range="2548..6452" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2528" colors="black"/><ColorRange range="2529..2547" colors="light blue"/><ColorRange range="2548..6452" colors="black"/></BottomStrand></StrandColors>  (w     ƒ  B        Bs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½ ÃÎÄ¹?¸ÒÇlÖ×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           	Ã  	è  	÷  
  A  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  m<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2501-2536" color="#ccffcc" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5793" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5002-5793" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5794-5862" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4243-4831" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2562-3149" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3223-3456" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3668-3803" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3528-3649" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5863-5967" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3889-3895" color="#ffffff" type="standard"/><Segment range="3896-3913" color="#ffffff" type="standard"/><Segment name="-35" range="3914-3919" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3934-3955" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3865-3881" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3032" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2649" maxFusedRunOn="2649" visible="0" detectionMode="exactProteinMatch"><Segment range="3033-3044" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:11:1">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2541" colors="black"/><ColorRange range="2542..2560" colors="light blue"/><ColorRange range="2561..6465" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2541" colors="black"/><ColorRange range="2542..2560" colors="light blue"/><ColorRange range="2561..6465" colors="black"/></BottomStrand></StrandColors>  (y     „  G        Gs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë½7H0ó±.DÅ®4±Ûõµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           	Ã  	í  	ü  
  F  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  m<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2501-2541" color="#ccffcc" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5798" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5007-5798" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5799-5867" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4248-4836" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2567-3154" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3228-3461" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3673-3808" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3533-3654" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5868-5972" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3894-3900" color="#ffffff" type="standard"/><Segment range="3901-3918" color="#ffffff" type="standard"/><Segment name="-35" range="3919-3924" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3939-3960" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3870-3886" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3037" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2654" maxFusedRunOn="2654" visible="0" detectionMode="exactProteinMatch"><Segment range="3038-3049" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:10:52">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2546" colors="black"/><ColorRange range="2547..2565" colors="light blue"/><ColorRange range="2566..6470" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2546" colors="black"/><ColorRange range="2547..2565" colors="light blue"/><ColorRange range="2566..6470" colors="black"/></BottomStrand></StrandColors>  (Š     •  Š        Šs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë92¥zS Ÿ°oy/H‚®4fôÝ ÃÎÄ¹?¸ÒÇlÖ×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           	Ã  
0  
?  
I  ‰  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  m<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2501-2608" color="#ccffcc" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5865" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5074-5865" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5866-5934" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4315-4903" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2634-3221" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3295-3528" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3740-3875" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3600-3721" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5935-6039" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3961-3967" color="#ffffff" type="standard"/><Segment range="3968-3985" color="#ffffff" type="standard"/><Segment name="-35" range="3986-3991" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4006-4027" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3937-3953" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3104" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2721" maxFusedRunOn="2721" visible="0" detectionMode="exactProteinMatch"><Segment range="3105-3116" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:10:46">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2613" colors="black"/><ColorRange range="2614..2632" colors="light blue"/><ColorRange range="2633..6537" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2613" colors="black"/><ColorRange range="2614..2632" colors="light blue"/><ColorRange range="2633..6537" colors="black"/></BottomStrand></StrandColors>  '®     r          s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇlÖ×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           	Ó  	Ý    !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ´<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5757" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4966-5757" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5758-5826" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4207-4795" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2526-3113" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3187-3420" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3632-3767" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3492-3613" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5827-5931" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3853-3859" color="#ffffff" type="standard"/><Segment range="3860-3877" color="#ffffff" type="standard"/><Segment name="-35" range="3878-3883" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3898-3919" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3829-3845" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="2996" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2613" maxFusedRunOn="2613" visible="0" detectionMode="exactProteinMatch"><Segment range="2997-3008" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:10:33">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  o<StrandColors><TopStrand><ColorRange range="0..2505" colors="black"/><ColorRange range="2506..2524" colors="light blue"/><ColorRange range="2525..6429" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2505" colors="black"/><ColorRange range="2506..2524" colors="light blue"/><ColorRange range="2525..6429" colors="black"/></BottomStrand></StrandColors>  '     t  %        %s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇ¹°o[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            	Ó  	ä  $  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ×<?xml version="1.0"?><Features recycledIDs="4,0,5,8,11,18,23" nextValidID="24"><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3003" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2620" maxFusedRunOn="2620" visible="0" detectionMode="exactProteinMatch"><Segment range="3004-3015" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3836-3852" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3905-3926" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3860-3866" color="#ffffff" type="standard"/><Segment range="3867-3884" color="#ffffff" type="standard"/><Segment name="-35" range="3885-3890" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5834-5938" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3499-3620" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3639-3774" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3194-3427" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2533-3120" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4214-4802" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5764" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4973-5764" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5765-5833" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  =<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="1:0:6">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6436" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6436" colors="black"/></BottomStrand></StrandColors>  'Ê     {  B        Bs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇ¹½7H0ó±.DÖ×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           	Ó  
  A  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  �<?xml version="1.0"?><Features recycledIDs="4,5,8,11,18,23" nextValidID="24"><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2517-2561" color="#ccffcc" type="standard"/></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3032" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2649" maxFusedRunOn="2649" visible="0" detectionMode="exactProteinMatch"><Segment range="3033-3044" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3865-3881" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3934-3955" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3889-3895" color="#ffffff" type="standard"/><Segment range="3896-3913" color="#ffffff" type="standard"/><Segment name="-35" range="3914-3919" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5863-5967" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3528-3649" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3668-3803" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3223-3456" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2562-3149" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4243-4831" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5793" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5002-5793" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5794-5862" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:57:42">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6465" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6465" colors="black"/></BottomStrand></StrandColors>  'Ë     |  H        Hs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇû‘›Ótƒ;ä@ým~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           	Ó  
  G  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  �<?xml version="1.0"?><Features recycledIDs="4,5,8,11,18,23" nextValidID="24"><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2517-2567" color="#ccffcc" type="standard"/></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3038" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2655" maxFusedRunOn="2655" visible="0" detectionMode="exactProteinMatch"><Segment range="3039-3050" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3871-3887" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3940-3961" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3895-3901" color="#ffffff" type="standard"/><Segment range="3902-3919" color="#ffffff" type="standard"/><Segment name="-35" range="3920-3925" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5869-5973" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3534-3655" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3674-3809" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3229-3462" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2568-3155" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4249-4837" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5799" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5008-5799" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5800-5868" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:57:33">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6471" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6471" colors="black"/></BottomStrand></StrandColors>  'Ì     }  J        Js"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇû�½7H0ó±.DÖ×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           	Ó  
	  I  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  �<?xml version="1.0"?><Features recycledIDs="4,5,8,11,18,23" nextValidID="24"><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2517-2569" color="#ccffcc" type="standard"/></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3040" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2657" maxFusedRunOn="2657" visible="0" detectionMode="exactProteinMatch"><Segment range="3041-3052" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3873-3889" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3942-3963" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3897-3903" color="#ffffff" type="standard"/><Segment range="3904-3921" color="#ffffff" type="standard"/><Segment name="-35" range="3922-3927" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5871-5975" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3536-3657" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3676-3811" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3231-3464" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2570-3157" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4251-4839" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5801" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5010-5801" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5802-5870" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:56:59">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6473" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6473" colors="black"/></BottomStrand></StrandColors>  'Ñ     ‚  _        _s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇ÷’ôˆ ZãFoMÒ<ìK‘õµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           	Ó  
  ^  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  �<?xml version="1.0"?><Features recycledIDs="4,5,8,11,18,23" nextValidID="24"><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2517-2590" color="#ccffcc" type="standard"/></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3061" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2678" maxFusedRunOn="2678" visible="0" detectionMode="exactProteinMatch"><Segment range="3062-3073" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3894-3910" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3963-3984" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3918-3924" color="#ffffff" type="standard"/><Segment range="3925-3942" color="#ffffff" type="standard"/><Segment name="-35" range="3943-3948" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5892-5996" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3557-3678" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3697-3832" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3252-3485" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2591-3178" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4272-4860" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5822" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5031-5822" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5823-5891" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:56:53">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6494" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6494" colors="black"/></BottomStrand></StrandColors>  'Ú     ‹  �        �s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇ92¥zS Ÿ°oy/H‚®4fôÝ ÃÎÄ¹?[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            	Ó  
@  €  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  �<?xml version="1.0"?><Features recycledIDs="4,5,8,11,18,23" nextValidID="24"><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2517-2624" color="#ccffcc" type="standard"/></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3095" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2712" maxFusedRunOn="2712" visible="0" detectionMode="exactProteinMatch"><Segment range="3096-3107" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3928-3944" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3997-4018" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3952-3958" color="#ffffff" type="standard"/><Segment range="3959-3976" color="#ffffff" type="standard"/><Segment name="-35" range="3977-3982" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5926-6030" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3591-3712" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3731-3866" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3286-3519" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2625-3212" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4306-4894" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5856" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5065-5856" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5857-5925" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:56:46">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6528" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6528" colors="black"/></BottomStrand></StrandColors>  '     h          s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇ[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N              !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ×<?xml version="1.0"?><Features recycledIDs="0,4,5,8,11,18,23" nextValidID="24"><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="2987" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="2604" maxFusedRunOn="2604" visible="0" detectionMode="exactProteinMatch"><Segment range="2988-2999" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3820-3836" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3889-3910" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3844-3850" color="#ffffff" type="standard"/><Segment range="3851-3868" color="#ffffff" type="standard"/><Segment name="-35" range="3869-3874" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5818-5922" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3483-3604" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3623-3758" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3178-3411" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2517-3104" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4198-4786" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5748" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4957-5748" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5749-5817" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:56:39">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6420" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6420" colors="black"/></BottomStrand></StrandColors>  9…     	‘  %[        %[s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìNÔë¸ÒÇ	=ö,ÐD?r¹ðÐNQöà�ÅÆ}âÿÀÏ˜;ˆãªÕlˆ4¥âÄ|«KÛksÕAùñŒ¸áMØWqV! ¸ b+wóP·�­aÈŸ‚Û¶ 0~]²�E8|q÷+J»n}ï8Rfv°áÙktåOÓ_“ˆ\Qâµàj€àì7xa„aÐç çÐ‚|OôFØáhÞeôt�š‚ò�¶Š(«à�f—Ó­4eŒ¸pøé»itõ=„5çkK¸?F<Q…ë5bjh#Öÿƒ‹žQŽÊ {FQÝ4ýNèÍ�ž£´Ÿqþa>(áþ˜}/¨TÐ®ÙHO‡æRÛN¢=÷þ‡ÔQXðouGØp†™Q¶±çPaÆI0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`DÇ0øüölHómðßápÈ±8 0Á7ÿS@óaõÔaDßT3ø~´ÿŸŽÜ†œ:çÞ°ßŸôÃœEÿ¯�ÏmuÃw×6ÄRq28Ü„ëN|çðó!°Ç­BðëüAÓ!ºßFÛÍ5Ï|�7ãØeÈà€Ó¬üß­>30ç�:È t÷czÔLö÷ý6øÑpýŠÏ¯<ÈN7MwÄà6È}7>µý³ë=ó;K/ZãÈ7Ïðï|³4AK®]Œ!ÈE¿æu?pŒû=üÇ¿Ð<œßìóÌ¬ñçü÷3ÝòÆð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>µû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           	Ý      ^  g  i  %Z  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ,2<?xml version="1.0"?><Features nextValidID="24"><Feature recentID="23" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3678" consecutiveTranslationNumbering="1" maxRunOn="3681" maxFusedRunOn="3681" detectionMode="exactProteinMatch"><Segment range="3613-3678" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6129" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5746" maxFusedRunOn="5746" visible="0" detectionMode="exactProteinMatch"><Segment range="6130-6141" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6962-6978" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7031-7052" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="6986-6992" color="#ffffff" type="standard"/><Segment range="6993-7010" color="#ffffff" type="standard"/><Segment name="-35" range="7011-7016" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5055" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5658" maxFusedRunOn="5658" detectionMode="exactProteinMatch"><Segment range="5005-5058" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8960-9064" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6625-6746" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6765-6900" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3722-3933" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6320-6553" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3946-4214" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5659-6246" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7340-7928" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5059-5658" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="5658" maxFusedRunOn="5658"><Segment range="4273-4935" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8890" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8099-8890" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8891-8959" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Mapk14-m" directionality="1" translationMW="41488.51" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3681" maxFusedRunOn="3681"><Segment range="2527-3606" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>e45d160f-122e-4b03-b75b-fc40320a79ab</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:55:58">2023.1.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..9562" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..9562" colors="black"/></BottomStrand></StrandColors> Õ¥     	‘  %\        %\s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›ä²�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M‚¤…òÑ¼äÎ|Ñ»µ:Å®4±ÂO}‹4Ü®|4…Ô}¸#ñqŸEø¿Â°3æÂ"8ê†uG Û")E8±*ÒöÚÜõP~|D£.8SvÜUˆh.(ŠÝüÔ-àAkXr'à‡öí€…×l…#ÑN}ÊÒ®ÛŸFûÄ™�¬8vZÝùSô×äâx„íF¸ 8;Þat9È9ô Ÿý¶8Z7™} f ¼€ãmƒ„â‡ÁEÊ*ø'GÙ¥ôëMc.ßþ:nÚ]=OaEyÚÒîÑ�azÍXššõ¿àâÇç�c²¨Ñ”A·M?Sº3cç¨í'Ü†OŠ8¦Kê4ë¶Fáù†¶Ó¨�}ÿ¡õV¼Ç�Qö!¦Tm‡lyÔq‡RL<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø1ÄL>?=�<Û|7ø\2¬N0DÿÔÐ<Ø}uQ7Õþ­?çã„÷!€ç¹÷¬7çý0çëãsÛ]pÃ�õßÍ±œAÃŽ7!:ÓŸ9Ä<<Èl1ëP‚|:ÿtÈn·ÇQ¶óMsß Møßör8 4ë?7ëOŒÇ9çN²=ØÞµ=½ÿM¾4\ ÿb³ëÏ2�Ó]ñ8²ŸMÏ­GÿlúÏFüÎÒËÖ¸òóÁü;ßìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           	Þ      _  h  j  %[  G$      G®ZTR

SMP4      BIðj  xÁÉÏ·Yzôïu�sŸ{úÏðN5ØqW±qWuY»mÂíB %V�`Å°@…K"ZbbwÄ.KX°á/È*R,�‰í`Òî®zëžá7ÞÃ®/Ÿ�ü‡ÿˆ¤¡q�s¡Ç®¿Ùîšñv_ÜÝßýæ›×÷ŸmÞ¼yóŸ~ùéoýéoïw¾üáoÿþ�ß‹=~ßE�_ü³ø	þEüoâKü"zlbƒÿ+vø€[¬Ž¿Ä_þ?ÿï¿xûç¿xü‹·ç_=ÿóo~õö×Ç_ÿúáÝó»ãÇ·ß]ÎïŽÇóótžÖµ¬©VŠûþúÿþï‹+J
IÀ !`ô`ô  =H!HŠA A@ªT²Y…@bˆª J¢’Õ ˆ@f¬0­J�¨@E „ÁÈJ« )"€� B8S�†Z+k5«Fðl´�ƒ/VJ†ƒ‰Sq„
šÀ„Ä@ „�B!H€R@P@
H-’ ™UT'^ÀbI×¦¢
µèA!Å„ É‚
ÀÓyªV3£*¥H…8¥D
Å ŒXô�€‘4<�8±ÊäsÀJ®Y}h¼r™,g˜8ñâ«Hü}�(¬ÐNe•iª+ñKP¬Ölt­S–5­ 8Uº¿ …´’’h³i´äiÎñ=%Þ�`­Å´«°©_}€%Ï7ŒN¯å²k][Æ¯@ `Õ‚¾…ä¼L>7.8¸øÖR*›ÖQÖ²¦–�4ÀÊ¹‚ª¾j�µdZ{š?{9ýå¯KÍýnD÷P>LlBGã‚BÔ”ˆaÃ9M:×x/Æ€ l-³ë^,ßž ·u¦`ü>(D]%·ãØðz�½óM0_-¾+3]»Ëe†ïÕ„q !¥.d;T¦‹åïÂøo�«k)2lÝr=^Þ�¾5aA ,×™Ýíþ¦>~ü8ã¶ÄDLÓººþþ•×‡§·èÇqHRâ�AˆÕ9£ÙµËq¾¤Ú·©°øÇ  ›'éî^Úúðô}ß;­ ãï��š—ê‡MÍó)IÓ6ðU7 (È—’7o>¾}ïn*%“ñû Uê¼–öæ¾].ïßŸ\³½¡ _.O6„À* ,™pÛÀæ'®l›Ý8œÒy9JÛ¹ì«E,L_|v¼ÿÕâö»J%;bXjò»ÐÖùi^C×I%ÿm„ÔãZ7Ÿ|/àñ¯‰—ã�[‹%þ]�"–Oì~ëåßü2á³í­ö@:-�íÐ:V…Å¤ˆ-—âîÿÆðá»Œ»ŽW…‰¦º`s·Ñ‡ëS’MHã B,�2öÈÓtž]ÛSŒJ)'×º›.ïÞ=å±íºþ¦}¾®ƒ½7#¦Uê5ÙíËÑŸ>¾?J{Ä``$â `Zj3¼ñýû‡oÓ¶*µÌËŠÝÖ­ëó!…®WT%hk…ûzÎÓñ~�ö°œç’}uûPõp8 c+$A õz©ÛWoúëÃ‡Ç‚»�Ò ÆŸ‚€Ô|ò~³Å5?^YÚžJ0þg €T
·ÎÓéÀvh‚Œ¯A 6§ÒÝõéx|š«uaÜ¸ééx°ºŽEh¢––)ìó^ßþ«·¨ãx×ßŒ¸œ�%ÝtNÔÈøs�
›æÚßÝÝù‡§÷k7ìI›ÏÜÜß~–¾ýæ»ëx¿s£Ä?…RPá¶Êy*h|gTXü„XÎ¹	7ÁÊi9¾ƒ Gb5øMÇùz¬2†¦jÆW Pleý^çü¼X+ƒAañû Är"»¾¦t=Ò47e�æÃq©Ð]¨n™žJêC;v.—óêú®1Àâ‚Â|Êºý<4ï>ž››­6…R!ñ¤®)Û]w¹<¾]Üfô¦FÆ×  ›Ö<ìw¸\?µo§EH¸\.Eo^ïýùéÝ{ìnÔWãÿ(sFØ·ëu:œà‡þX§çË2úV¼‘q !Væ¢íÐÈ|½%t.;Xã°ÙøÓrœ­ªÂâRÓµøÍv‹ËÓÉQÜ¸ñnIÏ×D�q¿Åzy>Ê&)Ñƒe6í¶M]ÏÙüàÚ*°8‚Ñ£L©i_÷a=~g¾ö]?ŽÓùr,ßºíZq™êÅÃßŒ›éðpNÃÐ5,‹_€ êuµpß®<><i3vZŒÿH•:M^¾Dóþ»ožq7l’‘Âøï‚+Ke7€y¾Ö‚Sˆ�–`×4i]²ë�-Âø5(”J3´–çuÚn•ù�jë‚hÆ/@¡XJ5t+é¸zŽê]Æ€Ñc^¿»kÖéðq•ÍÖ4), ¶Lk¸ÿÝÓwï>`|ysëòóùùyÐ!h,¾V)aÓV[OcÛí´]ò9»¦kTT,Ž  –êUÇû¾}:=\x‚VãW Ä˜ºÍ]c—ÃS±íÆQ«0þ¤®+‡ÍÍ�^OÙ­d…Å— +Šv¾.§ym}¯Xü>(°²f[·Ì§c*~èÌWaüOAP˜æ‰÷ŸÝ£ý«_bùô¾—ÉU2~¨—Œþ.¸ËÓÓiêváe•lçÓµÙ…–" j¾(wm(—åzU×î¤e>\]Ó´j"–%9ãxMÇì†Æ«Vaü
óœ9ìúér9­Ù‡þÕ~H‡�¥Ùî ¨Âø%(°º@ý¦qór]Zx§bk:úÍëO_Í�ß]Æf³Â:'}€P,~P/õÅ«0ûÝû¥¿ë»ì«0¾±TÎÍöõËfþðþaƒÝ²+ÂØƒ€Ôå2ûÝo¼ÀùÃÿwHŸ¿ØUa±µNUÂÞa½N9¸Öy±øPˆTrî{?]ŽWíB#&bñg Pj.U÷Úb>\²4]#bñ%aYfÕñuŸN‡sÙíç´
c
¬®«„ß[z^ Í GRÄ8_®òêþ%~ýÝ¿îîGTbùzµ»O^¸Ë»o¿1¹»�Áø‡ P,ŸÌïï^s:}8~œov[Åi¹&¿i:˜2 Àl]L6;Å|8$hpBÈVjsß}<ÏµÙô¢«Qr¶f?Úi=,¥o{5W 0×¹	]‡š–"ÿ#P(L)ÙîÕØØ7¿ºHÛQÁœ«6ÝÎä</Û¡*X™Vm÷ýº^Žó%õ¡ßMË2¾©¢_ƒ‚š`¾ÝÂ_ÖÓÕõ.˜ K0×pçé2-¾oœP,¾!¬ù\\ÿfƒòîá©lnv¢E_ƒ‚$Wk6/0�ÎÇ”m;îƒ+Ëz,EÆ¾Û87M“9ï½ŠÆ€‚šjâ8Žš.Ïg±¡sæÔâ 
XÓ\}wp�§«º][}¹ž®çÐt^ _�Úš.ØÞ}~|ÿnõíØ&¡Xü)±<­®yu�tøp>sè^ì¬]æóšC×…*°8‚Â2Mp»ý�œ.o§	·ÃnÛŸpZÏêBð¬œ—u»³OùðvÛûÁW1Jü
ÔrY]{»ïóáéèJ½€ñG ­?´*)_Jm×wÌët]\#j”ušýæÓ{)‡o?ÀÞl7Å²€ñ@¡°œXú»»W˜?.y³o»Ê&Câ?5ÉÂè™ÊqÖ£,KqØ¶nIçLm/jbñ5(`]k–nÂ<_ŽÎ…¶¡Æ=Ö¼X÷ê>Ô‡çÓ…í°5©€XlAP³�QºÛÝ�ÏG4ÃèµuÉ³tŸ¼Ôùí‡ÇÅ·Ý°F00z”ie{{{ƒëóûiÙŒÛ`„T–šDïL–YK� &ño‚H¥X·‹,çËu|W%þû°ºTkÇ›Š<ó¹óMO�;Ð’Á¹‘Ó%tê›ìÿ6hk)Úl}W¦ÓT|çš�=ãkPÈzB÷/nêñùƒÕn½V–’èüòt©]'Øš&no^Ü>>¯²ƒ�Y]g‘ÍÍ~¼^Y¤�/ªq„Y‚H×ô×³UuÎ;‰¿2›ÕÐî¬�ÓÇ§“öãØµË´^Rµê!ñ X™Öì»ûPÝãã{ñM;ˆÐQ$¾-—äCçËËÕLÕ«Æ-ˆR–UÃfgóõr9ÁAµ$»D×�ãr�gˆïû€µ®S…vÞ{JA¡%ÝèQóu-€J›œ	­Ì«“þö®ÚåãSE×·A”`­™ìÑ6Kž×JqMuŒ?Y–’]³ß¨/§ÄÎõPO²®Õé¶×R–«Ù >ˆ£Ä
Z¶µ‘Q‚¬ù¢«ÒK JÜÀjrkhõ5]Õ»ÿ6HÚœ'i÷/vžÏo�“ºMç!ˆÄŸ�V'Ë]¸·Óér©­VOHüZYŠ…æ¦Mv>].É‡­wu]×…
z'Â2ÛÚéíÐY:<sjwÛ±o—r]RuÒxGW!ñ…Bfšr]-å˜àÄ‰W!Ì’7×µYÖ5ëéÕÆ•«“ñ<œ�§Ô¶¾óš4¡)€ÔUWçû^e]gCCméi9U¸aã-]¦’¼k:ó �€ •–‹ô­KrÍS×7#Ä8§µ
œ§`  “ŠÓÞ·ÎêE–&5Ú˜32~¢–äF€5/Uœi;�†ZJR·iÔ­ëbJ4¢‡å9?ÞxYO�GCi} µœª…àÊt�	?ì½æõ”é¤iÕ‰Ä?ƒ�´TÑÍ~´ùüáqAZÕ@)¦År�Ø…û]_¦ÃÃ{ú±k¨T”ó] lž­¡õ”ø_‚D 2lWwZÏ%y8ßÐ9@âç0¬5¡ía8#;Qu¢U$‰juqhÛÞ¥2­‘v¬äR¤A E±ºßtªK¾ Ô;($¶ aby)ôÝ8¦ór¼\*ƒötUÂø¢'hT\µr‘¢ºõ�­kºª	æï@€f¥d4~©9Cq"ž�Ø‚F¢Øj®éÏr�êïWEŒÎâ#‘]©Òv®©Kº&ñM€2­Õñ"ÂšSV¹é<.—ã¥¸í S¾šùÐµ³ÌËTáà�ªQH0Àj’šÎW,×E•�s
ˆUæVB /uÉš½ÂAÄDâ-HÂhðAÅ­)'mÌ� $þC�¬µZ‹¹V!u.…ÎCA«­í7MZÊs=­­¶"j…Äï#zBÈšÖ†]ðVÓs¶Öo¶«Ùz)0¯MS]eªk•p³åùt¸hèÚ`â tE@R¬&Xã·c;]§ã�6ÃjË:Á€ÆSRãï�¨ƒ•iƒêšsN�oºF�×%kº.¤šO&ñª L¢‡Ä„Q @±R¥hæ2¥*l¥Z%T$Ž`Eª0×ª~„rI+U‰¤UT5ç)¬•E*E[8ÚjšDÅ�0�J‘ø?‚dºŠRçý†®,ë‚Úh�@¢A‚&5&TôÒÈšrj¬“  �€ _Â`(jÎŽ­ï´Öy-¥‘Ö7…eªÁu®S¬ëUÆ0„ZË9{µ®qN©æ¢ß,õ’
Zm[krÎ•U@@€Æÿ(V«‰‡«‰ÔvpÌe!|­È�„ �b0�R¥VA CI¥šÀÕ¬ŠÞ5Õ¯ºdcƒ†ÁD¬–R¥uM¶¥f‘¾¡ä9WóÞ‡¦øœs­¶ñ;®+.„‚R
àb"*–k’¦o½•iš†JÔ
¢€3²TªóPfË¨pÌÓVÌZd]tmÔ©H �"ÂZ«9UO”U
MT©F‰/@aÈôNEk™uöæ]£Ž–$©‰8*@$þ' Mé´¬hÀ’ç¦¨8ˆ˜˜T
Áx‚„˜VÂ¬Pœ¨YªÌAàÍJ&©€ ¤bÂø» Å„0R¤�²æjŽ¬f•¡ 1š‰8úBV@UÌj1 ñWkÉ…ÞÑ,W«¦*4«¤"Po¨%ªwÐZ‹AÄ*…"®
&ã„	( èÖ¦n%K%Ä´RI…	L· À„‹Ä1*H!ˆA `BÄF=EhV¬3#AQŠ B�	1ˆE
L ƒXÜBL` ‘F£Š8/*Æb™YŒ"PQª‘R`bxzQCÒ\k]…*©0ˆAH@h
ã+P@ �š @ªbBa¼& X!UŠ±šQ]£JÚÊbâZWËJ–JQ§¢€˜ $�Š
à¤g#,uQDœˆ3BÓB1! 
F
Ìàiˆ¼2;´‚V|¹Öqðc)V]3ÐEŸªWe|Â,×ß»¦$NÎœ:xŠ±.RÐw€åens@€¨2´ä’×¶U)ë”�s]—ê¼WBk|‚¥ä"¾w-ó4ª¢
HÍÆ®Õ”&è¤#¼1þPh–k’X®3["˜7¡Y¼ÛhXÖëdµc‹¦Š2¾ÅXl…¸ i5À;§¢Âj«)Ã&Ô9!^z2Þ�BcáúmHå²L	�wÞT´²µ®Ë´²qÎ7€0~	¨i*²¹¿/—ÓÃ•CÛ@0Ž ¤ÚÊú›Zí4¥	^Õ„ñÐÖ¥4áÕ˜Ç‡s•nS›$`@HµÅj·¹NÇ	Ú…PÄÁâ×  [kÒnÓÍçËqœÛŒ7&OOsE76&Jddi÷à8J4Œý¶^Ï§´Ž¾Ñâ„ñ‡ €:×„M¿/‡ÃŠ�¨ )°µ˜ï÷­[¦S¶¾ñNŒ‘Y$l†u½žsåøùÿü×Ø~xÈ5øÛí�¿>>c7öf ÀTV?ÞÖùù°ž»íØ°,~
ScY.6¾êÛzü.•WcëV Œ= ¤Ùoö[w|~>V©M¿¿³ùðq²~h[#À¸É¨¥¿i›t9.i”®’ñk�Šr]¬}ÙøÃùÃ]Ók�Qâ  ¶ÔÅooFLOçµíwÕdüH]snöýf:>žgmÑÜÜ¶óùé=}·E5€q p™SssÓ<?¼-éæ6Kÿs0zä2wþ�¶óñin]íöÛ=æÇã¡¶m·ßï¦ëãQÇ®ï` ãk0z¤µ¢�éðø˜Û~+¨ ã÷Àè1¯©Ûß|óø­µ�¶ÃNt~zž‡ý&T¿RQæYÛÛ½?>?Íðc·¹ez{xæ.ì’`|Sc½^à_�rz~ŸVš}7Ôrxøp‚4/îš5=<¦S×lv�NŸ?–n36€ñ�A uÎÖÞ‰{¸>>cè¼/B
P¯—º{ùI;}÷ÝR7/:830¾£G.«wÐëå¸vaP!,'`ÿêvIO®ºpó"¤‡÷Çµ»Û¶É ÆŸ€c®U7£·Ó2¡÷�Þ¤bY­¹¹ß”ËÓ‡kØmº"f”ø÷@ œ×¥¿Ùc¾¾½Ôn¡`A %-ïÆ’NÇgBC
ÿ.H•Tg^ÞŒËáácë·�‘
‰¿F�”Ùß„årz@ßn³[Æ‚Tä5c3nÖéúXrß5F…Å(yYëÍý'˜?¾»rß� ŒBŒ™¥6V×¥Î…ñ¿pI¥Ý¿èêáÝ“ºQPÆW @))»áõÝ¸>>]Ü×`j”ø=[óÜw­NOF×„»qt‡Ãsr›ÁAŒŒßØ<ÛæEëqzwªÍ}Æ @)yFûÉÐ<ž>,i×5û¡Çññò†Á{0ö  .kõw»Í|ùø¼¢02¾©RÒÕšÛ{¤ÇwÛŽ«P£f+lnÛp™ž¯¥mÅW%Ìå:¥i³o§‡ç‡ê;vÛv=<eé6p¤0þ	 N+Ú;AšžNi¬í¸o›|~šÃØô Á8€B±<-a3ðœŽ§9ÙãVN§ë±ú†UañÏ@ Ù²vûM>/çnh›*FÆ¦Æ2_Þlq>¼�°ÙtFŒÀ–ÄæEÏéüx°±ÄŒ_�€Ô4å°�ËÓ5õ}ß˜�Ê2'ßÜùr¾^JÓÃW…Å?dKM·ïýõ|^ºÐ;Š °ra3Üõœç2´£
`ñ©’-•ñö¶¬�ï'ý˜\XüŸ`J+×©é^Þ…òôt·m|À:¯nvfçÃ»Ðn�T D�·<žÎ»ÛAd:,Ù9	ãNêù|X}; ¬JPÈµZ»Ý5ér­çAGQˆÅ¯@ª¤’ØÞß6×ÓáCØl:-B€É²ïod�§+Ã G�ñ€Baª‹lï¥ûx:¯t¡,~	
�\2‡ÛÍ’Ÿs²Mç!U¿I%£½ßvO—§³«­7[ŸOgt:‹?!†´×ßçóq©�ko!Ëóù�ªC»�ß;×oœO
‹=1,éê‡OÇôøx±°ïÚÕe1©¨×•ÃÝØ�ÏOMÕS`ñç Ä¸ä¤»½^OO§‚vG
ã+b¶®ûmÁùaª¹ïºý¶I×ÇÇ2v½§P¿ !fë¢~Š<?_�±aìA¡0Õ„p³YO×çZú¶W„q !V¯uÞÝíûéôî©ê‹Á›+Âøg ÄòZ9l‡³�—§ìÚ°¹÷~:>èn3zÐÁâ— È©bxÕáñx:Û U`ñ5±¼¬Úo1§ãõÄ¦×}×´éôœ-lz@`q…’�\Ø÷y™�íÆF+Äâ Bk™Ãí]gÓôàÐî ù|=­®Šàš2û].çsñãÞ‹Va|
…©.>Ü¢NÓÇâÚ�‹_‚€Ôe®aøÄwÏÏOÒv=@Aâ…áþîÎ?|ÈÃ¸qÅeaì@mMé>»¹==½{Äx;(¨´Øƒ–%eÝíêõ|<&qC·Ù”ù|¼\Ðµ-„bñPPë…6Þorº>¬Ú»ûFÎç§G`Û9ÈTfwýX¯ïæÖoÇm�çãÑÐô®I"
j^‹·åš/ÓâÛ¦§‡ÅÿX™ÂÍæçÇÇ¬7]ªX|
…©LÚ½¼Gz8}sØn¯bq
,¯&í¶qy9§â‡Ð‹¯@¡0Ya·«áº<åµ×…bñ@�Õy-Ý~»I§ãa�A+Ô´”fÚi:çì‚öp°ø5(°º.µÝÜ�îz8Ìhún?õ|\5ôAjñ+P(µLÕõw:ç§’BÛon­®ÇãeêC¿ß6r¾>Ÿµkƒ3JA�å´rÜµN�gävð&°8€‚šçÄö¦+õz�W‘íÍV†åz8,î¦m}…X|
,1Ùf×uyÌÏ*½z“øG  ç’›í—ët¼¢ïŠ0þX²Œö¦/zzšmÛ9M*ñ�@�å5i·ïô”Ó„�(Àd‰ÝîVy9’Ú
‰ÚºVÛ�Ûp^>ž–vN}‰ÿ´5WíF¯ó<]B'
‰Ÿ�¶Vbš”×ëÔX×¸ØÀò’Ö~ïom>žB×"q
s2	Ýà.õ2QÔ«‡3Ö|!7}ÇSz\×A{�ÈdætÀù2¤Dâ?™kÁ°íûj—ëT½oRâg0[}·ÙækÕ†è· Wf¸½¹¯Ë\hŠgü› åÕšf×J9§#¤35‰ÐòZè¶¡…]O×3t³é½Îå´Ll\£*ÿ>È²Ûvô(×s9·:t7¥=Lç	l]`S%~
Ú‚Ü6wNËùzNÝ�Ž-—ãy©­Æl^Îiñ®mÛTmž’¨zçHü)hy¥º±[.iÉÒ9¯�ø)j^
ÆöVýeš§ë¶´‰ÿhÉÌùMïSºÎ¹µÖ5*Ö¥ÂÆnãòz.Ùo›ÆÓIü´óÚïÌ-órÍf¨²NË\k«�7_ã'0[X}7¤t€§ƒÁ1þc�¥ÎæÜ0z.×ë|õ�Ûõb)k"T½˜Jü=�	‹u]è«¥utÒŠGÐêZÕºÊZÎÔ#8S‘Øƒ†:Ã|ØåTÎëR\è j�øCÔš“Óv,®–iu%h#J‰?YS¦êV<®ëËà‚8•øS�È>Y«[éW+ÓR¤s[§Yæenè\O‰?I³Çvp~.ÓÙ‰‡÷€HüS�`É³ßmCÅtÍÅ‡~ÛùÊy™½Š´*Œ_�4&º¡UÔåRÌçœ@âÕ’¬êzß/)_eñpÃ XËõZMÄ;…ÄŸ�¨–uq®í ¦eEn}?º*óy]ék€‡hAZN¬·ê§4­/-š¬{˜Ð’$ëú±‡�×åâ!Þ;@$f5QÑ‡Æ­ù\2TB0Õøg01–º(ºÐI-çRUà �Ø�0r5ßÝv~J§ƒemµËŒ/=K]=:?B—¼G/Þ™Jü$ÍV£ê®w¼Ì‡ƒ£o‚h¥d?+ûÖY*Ïi±­îƒÊ5ŸQ³ÓYæ<­ÅI?ôZóåš'´Ý]7åéœÀ­8ˆÆ$,¹Å»64’ËœJpêU‰Ÿƒ¤ÑVSk·DžSUÏV•5§âš¡˜¦ë\Ø„ÆÁ´ŠÄßaVR©êÏ\/F¯*Mu„Ä¤‰å¼6Úê$ŸÒä�ÛÓP—¹"{çŽ‰·ˆžÙ¯Š6´•vÎh\³u`I‹�'
ÀYü[ ­&éZºšóêªÓM•øoÀ ³²:º!ˆ¬ËJ4¦MõÕ´Š ˆ�ÅVçCg>­i¡8§¢ (o=aeAiBæ¼\SišF<•ŠÄHTXÊæ°Ù4kš¦SB/�S€¨³&ßv]µe^Ð©´êªˆ©Å;¬,µ0¸’¦TUû¾¥åsFÝèiùR«(‚*…F$þ4RŒY³…Ðx–ëºÆ&Ø’r¡«N©J ÿ¢7Q_-‰Éà}µ9-T8	U$!&!Ú.0•³¤–œ¹Êš˜]¼ÔÄÙUç¤1…Q(ÿPÐÈäŠ5Í r™«Ö64
µ„L—Õ©§Gf@-9×¶ª¹S.½»F2ÏYs6�¶æÓ„²íÛ–\—¥àÕ…"¡Å&TVK‚´Ò&— ˆˆ£7˜ŒHdMš:ï­LK�* 0 Jµš+ƒo–¼@|ß£rZQZqM1!•B*„d
U½ót¥ªâŠ%þ70„ k§!d+¦U¼4¦beÑ¢¡]RÎptª• P@%•ñ§ˆž •‚Z²hç�”ÅŒB� 
2™Tñ½S–µ˜sÒHµ\“@�ã?€�F¡£XÉ…ÚyÕœ­¢hã\±2am´mà3çZ©êTD*Œ@àÈZ
œ¶ÅYZ¤@<Š‘B€H-«LR¹Òûêrffeã=�!ÕT¼	„„Ñƒ 1Ôjô®�`1)tæ³Ôb¾ESj¶*ô¢RQ+ "b˜ÀbÂÄHÕ AbÍæ´a“˜ˆ¢Þª%h®
8‹[ÂPA!Ì¨Þ‰š%—…MõÅ’/U««�Ø‚DSx…ŠÁÁÁªUŠH|‚
a…„S5ZòÎT¡Õ2ÌKCÉ®¬�¢p!…dlA BÐ¬"·@£AÈ¼(ß,sZÔ;Z’C«Ma–ì â+@À4€€™QïØjYÌ±	<k™‹õê`,´*QBƒý÷ü?ÿw÷cð/þ!šD«UhB $ ŠP !` L@2…T
¨ 	Â`"&B*15€ fFcj•Ø@ 
!P(


ˆÅb ˜�b
TTV13Â B$…ÕX­ÂH¡¨8zS­Öj•¡T3Öj4háàkMäê³zç�À±¤Rj1Š*…‹RÅP@‚fb8s&C�Y@3ËbŽƒ:Z¢IÔÓ›‚
B`‹BB$X­’âZQgb«.(•Žâ(€Å Ã¨Îµâ%iMUrñ)°6 (
A)ñD­9{„Þu%/àÑH0­ñ%hÌMn› -mÍ+ÔœÀ¥ÖIzª®×dªâª«ñ_aµÌMmÚÞÕ:­ÅjÃfô}ªù²T*'t5þK-MÓ
m©E	q5~ÊÒžýâ6ãæØž¸v.„ë˜…¨¥s¾Ö5­pðpªŒ?¥JM¼ºu)Ég…ó`ü˜B=µØô®Nç¥›÷ÁßœâƒBÔµ²C‡tJkéd0gÊ8€BfÉÒûK}FÒ‰P· �Ù-�ƒåy¦o´£*ã ¨ù�ÊöóðüÝ; o›±ßƒ“n›�QŒ)Xª¸màu¹’Úº`¾ZüS”\'ïöãn¹<�à]§0©qJÅZsßß¦Ëùz:ÝX²ã
Y²©Ûtr]O—ì!nób£çïÞ^W¿Ù(” `LRµmYÊ¹˜ Q511³:ÓB¿)už¦y„ûÍýõðöø¡ïFï(&5þ.Le>ý'o6ø—ßüøì6 W!%þÄ–zÞŒ/oÆëÓyžÇ h·;ÍóÓ6}¯F
cF�¼fóÙ§eyÿ«_mëÂþÅv\¾ýðû­·j (,W“qhÏëõ¼×S ‹[be*Ønƒ;]ÎWZgTXü
„X’µ»ÆæSI�öÕWaü÷@ºR–ÙúÛ[âñéÙ±êíM3¿øðÐ¡×vlÇãr˜PÛÎ	€¨×j»ÞÍé”µŠþÍ=š‡·¾{½“„
Óº^Ïþå½ŸÿúW×~ûZ™ŒF‰/A@êšÙìÆÌëÓ$µë�_ƒ æ´\ÇñMkç÷O§0î$›%þ-P(–¯æÇÑ•Ë:©kz¡ƒÅ¯AŠØr-|ý[?Âá—þúº½Ú"¤Ä/A@êœR¿ß»ëñÃ‡ÚŽ®ºû×!ýúÝ7×íýÎç¤$”ËeÅ‹ßzƒo¾ý«©Ûì¹•½Ÿe´¦íîÇ°Lß5Ø†¡PÀøÀ9ew»ÑÓåôPàÉv»ÑõòøÔ¯áväéáÚ}¯(B
�Òö¯öx|¾ ½:Àø%=Ö<óöÅ¦§ïÞ¢kÅwoîK~~ºb·oL*$¾£G.‹ì÷û:�žJ¡¿¹§Ãû‡uØmÄ´‚€M“ín_:œÞòæ®ogx]¦áågœÞ}—õÓM›¤EêuJíëôøþ#Üö&¬&R!±éJ™Rêî}Ãççc¡ÓB0þ…å�eÿúÖ=~|ú¨·Ý¨I¤Bâ¿BÌÖ‚n×£\ÏuéïªÂâ *Ëå`·?ú×qûÿò[Œû!lÞtÇ‡ïN²éºÐõs>ç„žÃíÎìtœÐo:€`ü©õª6ö2—ãl~ðÁ” EÒ´Öûßx)øö›‚›ýNI@y�,¼ùÍ~~ûëãq³Ù Ýï$�ß=…a|öFÆÀuYºÍK].çÍfƒf¿
“{hêçÞ?Ô¿:¢»?î/bq0_ÌïßÜa~z÷q†±(��Œ"n×€§kAßz‘*ŒP˜Ü³ôo¶7îÝ¯ž&¼î/mÔyÝí¶)§§‰Üˆ+ã+�
[æ©½ûìf·¼ÿUÅþV°ÂÀøc0z¤õâ†ßÜnùö¯?/X£Ä`š'wûùm=÷í‡v¿ï-i&ã€+WÃn›x™ÎO+jÿfë/×wß7;TÀø3@�rÙì6ušO¡	Î\5 d2å¦.kòpÎW‘*U,_×0¼HËÃátAßzófq!ÿAðÒkëš–ø~ž÷ð�ÆsÎuª½¡@­Ú&Xž" h¢–4’€Q£ö5´H&6Œ	=´Þˆ‰-Zþ	bÕÞµ×ZsŽ9ß÷½§çöºÌrmóq(ûöZW71%(D6øå˜û¶¯ê‡™t°ô�*-gÞ>Š}|~éái–.F¦„X-ææÁ×|-ð£„i!†\K8}ˆîó§×^—iÔ*`ú!±–›ãp«ûkóƒÍ›¥ß ð¾rzúÅ0üú[7½dÖB0ýÀ|¯úôvÄþÍ§Ÿ|ðo|€5W¦áv»ìq˜D‹ÂÒ�žs×‡/"î¯?[qˆ~Zãm=_»ÆXú ¯�o=Öoî÷áý{WXšA ý–eüðÁ·�_¿Ôáè÷X°ï×£ÐE,M PX¸NñíÉßî/¯î48©
ûvc|7Çõó×çýô°¸#Ó¿…@­f�§£\/çŽÓä M˜>€ë[éÓi®/ëëe«¶|÷¿´�ö“ßç:ÀôCbÌ¹LÇ÷ó”¿yÞú2ù¦€¶¿V™Â`Ú’­ÆeAÛ¶ÜýÜã›£¾~¼lÇ§q”¢°ô;  -×¼¼9×ço¯e:.Ô]`i!V÷¬ÓaÑr¾Ý·g
m]ËñíÛ%ó³¯/C8Aª€éW@@z»Vÿðåc¨¿¾ûá0j#ó¾nf‰U@H/×æï—ÛOþüù4?MÖ»ÂÒ€³{)óã»ãáÓÏž_Žãažæa-×-ëÄa™"ÖÛÚkÔ0?©–óóMmÐÃ2Ùëþ|ï2�Ô¶2<r//ùVŽÑöÛý|ÇA M˜¾è·ÖÇ§Ç¶®?¹Ž£oÚ…éß‚‚Þw±i––ï¹ Ä�<(°\îrøbîýåã‹æcWR˜fP(MVÄÃ±^ïÏ¹»895*ÅÊ­éãû7îòòéòòö°°i¦÷ ÀzîpGÏ¶¯»ç]W¦(°¶W[ŽÞÝòù²é8’*–buííðþúúéevÓèÌ©¥ï€«¹õù‰e»Ÿ?z=D bi…¬•n>r{Y_¶ú#LÄÒ¯€³µ6÷Q¶s~�ÓÌwaú>(è}mÞ¿-rY/¹ET,ýO�­�ã@¿¯k‡ú QK¿
Š®ôËÄ²ï™.Ÿ"XkG&«ù¶¯Y–Ç§Å¿\¾~öêNSxÀv½¾¶ÝÇÁwˆ¥´²7·,ƒ[×ëKý@O±4ƒ³½×p|˜e}½ÞàG„"bé?�bmG¦�µì½Aè�3_^×›;Œ‹v¨¥°µ{oFœ__¿õ˜ß•–þÈÚJŸNw½ž?¯ã>ß.Ó”?}s_ƒ?"Ös~¹sZ‚ÅÒoƒVŒnZû~©d¡‡¥¯@a­„_4”}-bpÒÓ?Co1.Ôv¯ƒPX:€«9Çñañz^/nˆcŠ°Òv™ß>ŽÛõåq:ˆˆ‰¥/ÀžkqÓc‹ëúzs£ŸÔ éZÍÓè±å={™\4•ôPÐr69�Ž¾|óégwø* ÛZKœŸX/ëçW2B VsƒžbiÛùz³ŸMÓß {[•óä‹m[ƒjPHú(°¶î=ž×ËíÓsÇ84ôóº—qr&é¯�È\ÕŸ¢{½<ßWçÃÜc©Û¶^òà¶z»¿f5�À¶µì—Óƒ»½ž¿1ºx8Ìã}]o{÷‹÷P¦Ÿ{1ºiV¶í–eÓA`û­ÏˆH'é×@­ôÝÂÓe_v†) "iÖK•0-!¯åÞê Ñ«¦#(è}7Ñ§­l¯µ`
NM�°óñyÛ÷j3]Ò	l{i~9Œe[¯w‘Ã¨é»`/¬Ç0^Ûíöm6,ï¾˜ñòíË-ð8`é/ƒ,Fà4J[÷ó]ü0:¥3ci»ÍÇÓûýÿõo°ÇeÙd½ß+dŠ]Òo‚Ök3NnÐžÛ½°ã< u]›PC0g`ÛönÇw‡‘Ï?�óŸ&?Æ�ÛJ‡0õ`’~ «ýfom½oæ¢ØÛNýaã^r{PI†Ö‹y€²Ôâ`^XïY– µß«¨9O§éWAt¶½?¼™y¿\_âñ”t„Y!–©q[ï¥NÞQ$}C+ÌÃ° \siNG�ÎºÝ­T‡ ’`Ë½Û2/óš×óKÖ!D×ÓÂZ6µé ¿ïÛ}£‹ÞÒw@“n[µx°çóõùzà$Ú¼™•^Š8	^ÏÏwÃ8OŒ9ˆ×¨JI4ô’Í†ãaXžËçí•]’fuÍ&] $} a½Vm1Žu]•ÎBV³§G=ò|ù¤q˜‡8: –:4Žc@/[ï¢N‚©¦hµv‹ã2ºœ_î…Þ»(pé×Acë[‡.Ó¸Ýï×­5§q«vÍfPŒtšN°^³–pcÅý¾B¼ó"P˜ÕFÃ¨½ìD%ª¦‚½fÚ4¼l×}¥Ó9h ¨IO`µmä0»ÒÖÛ9÷eˆÑQ%½I+®¨³ƒÛÊ-„GÔû&EPSIHVkæÂà5—^
ÌÁC$}€�Åå®a<öýj°à¼:s–&�luƒ÷Ëìj[¯Àâœ‡ é×a`¯¥Z�cgy¹Wqó8S{/`ƒƒŠ¦ïÁ„ÖjVL£˜•½uUá(é�A¢÷¬Õ>š­å†æ�xQI„õV:ÃìåÖŠwðªi	˜Ykc{É0§Jo€¤_I³ž[×pZúZ¯·Ëí"±^ýè}·­lQéTDÒ[]ªíì:,s±õrmŠ0xQB )À@t+ØÕÍc,}Ûn›þ¤ßúKÝGÆq@—r¯¦�qtÒú½otªIÿ£¡µ²Åxx•/Ÿ¿1?)é”jé�#-ku~‚”u-YçãÉÕz{Ýw‰N€H
01°e‚ÃÉ™m¯>Ž…
í`úÐØzmAä¾èL»Hú“N ÷ÌâÆxpµÞo9øÕ‹ïÚ[+*z@Ôz»›b<¦°åËÖJð�¨Hz„	ÌZ¯Î
ö­™3…o"�ô_@¢÷ÚÔÍâ]­[6×}w&ˆ¤ ¢·lŠå wÝ¯µù1ŽZóF-xGëÍE%}‚c#u‚—V÷&ê
�	«EÇ© Þj7Ïà¡jŠ  !Íw	>P,wC„‡I@ ‚ ¬[UœƒÙÑé»!…èZoµ»è‡neÓ�§ Ifì€sÒëîºÐ™‘ Hú
D7­eiaÇÖ¯ûzŸ‡èUêNv¥*%ý#i…eT‹v®e/Ç�‚]îÖA§ª]`­í‚0à~ë9À©²±™:@˜þH±žwÒØëµÂOñ€º®¡:	** !hB ÍjüÕ¸ndC—ÞÍ™(…"¤ušWçU·Ð¡*)@Òo€4�Ê^ÄdŠÓÞ÷ý¶co�{¶"â�„�fF'Áu¶êŒ^ X7ƒP$y`¡ê¬0Q5!$ BˆŠÒOÎÓÖ’Ebº‰)!é 
‰hˆ&l»	á B�ô`0�ÖZ÷~Í{É&ã0ÀY¿×¦Ý‰ø)$ýL¨¢³	�¤ïƒƒª3é°(•„¡†¦¢ŠÔÂ*nL«][óÝzkµ	DBL?€ÁDf%"¸ ½g¥8 ƒ˜€P“ÞÍ QU[-ÕÄu“ôK Í`*^|g®³†¦PJúŒ€ÀuöBèèÔ,7!|`hE7¡�MP¡ê ÊŽNvUThÖ{ÇàCÁžA�r¯U»‰øN$ ¦Âô·A±NÂ‰ôVTüL×³5¯�Ž½ö¦Ýu‚é$!#Í"�EÒ�@€Ùª´Þ­S �ô]P(€QºTí‹ z¹ýêá‹ÿÛ» ©A3ÐLŒ A@@€ M
€T&1ˆ	!4	‚I€T*E°ƒfF 
Qì E " šXëS¨U%¬u«€Q¥%  €iLbB*“‡� (€Ah  
ˆ�ÆnFŠ‰¡£ºŒì;EDU B�3Ð„ç…d–^ÕyçÄ¡¸"„§Ö^¬‘"ŽÑ�Ö N5öÐ­¸Ö(¢
M„„�¦ 1Aaò À&  &H£‘Ô ¾³jÝ}§Š¨1“‡Xò  ¤�„uVß(apb®e+  !šþ¶Z¬…ècëÛžµG‡@×ÓA 1KuÓ0šík7¨z(Ó?�^kV‰ß­®½Åà�Ä®=ý(¤6‹ËµÝŸï•qŽ±9’fE¦àµæœÅ›WeúZÑ�zcËû¶™ÎÇîÈôË hµ`�ãìú½~­êæy¥ç×¶zaú°Àd˜wßn×»„°¼ýâiýôñ¹�ÓA€V3ü8Ž¶­«¹èƒëÎ,}
Ñ38³b¿ß¡.Í	Óß…df‡CÓõ\[ìÁ`ú]`ÍÆáfÛ./[‹1P¦l{¡[žö¾>çê|01aú?  Û3†·ÇÓëù›OÍ»Øý›/öéœã›ÙU€0WÛ^0¾;F{yy…#@0ý˜<ÚZäðápÌ—o6}Kë&’þ `Û†øæI¯Ÿ~z}�‡î:`"@¿5ß?áååóÍãäBõÍ$ý&(J+ÃüÖ®ù\n''�IÿÐÊ:„wK«¯ë?xGÓ¿ô­ôåÍÁ½¾~þ¬á0D0±Üöey‚^žoex¼ÈôwA@Zí}<Mºç×ì§è|WXú>PZ©rz{dùöÓ*ñi(bÒ!éwA@z»wNO¬çë%ãìA‚bíÖùø¤a»¼èñ4G_¦/@*ìÖ·ÃÓ{ØçŸœëñ8»B€é; ÄPj•åaÆú\Û'FÒ÷º-Ow?_Înœƒ‡�T²4sÙËç\fº32-`òØË:Ï_ÐýäóK}<N:À´€TôíNÿnÄöòùúªs˜ÞbÿüñÛóÒ5¾}ÿþþúñåî5Ì§w§öõÇÏyZ–X0M „½nÙŽ(·óKÇ°šÀÒÿ éõVýôù|þ<´Ó›™  U6Æ£Èk¾ìC:Å¤k©:×ËÖ0�¥� j¯˜Ž]®¯ëssO“âþrÛãáà F¦ƒ ¸­âžžôúùë›�æ9‚ ¤Xƒûy½ìûaˆM»0ýH•UÆ§èËýuÏŽßbÿôÓûÍ-ÃòèT>}º|�6�¥÷ Ä,—6žŽ%¯Æ%@�LïA@úžËòðf±Û§¯mX&ßÔÈ4ƒ Úž}|Âm½Ÿ¯{Ïãòó£?óÍŠ·ÇÅ ¦?ô5ÛôpÀçÛ§WŽa¦ßé¹mÇÓInÛókÀ0œ–z¾¼|²Ã2ùì«Iú BŒ¥twÇv[¯ÆÙTP¬®M!¶|®2ÆÑB#ÓÒë­ÆñËùüRâñ Ò–þ9H¯·>œúþrÓãaöR¦ÿ
B¥în~ïÊ··sqK Ì@aÝ«›N¡çëj'
`i!ÆÜ‹{8vlŸ^®ÍK|xåõå¥éÛÅ›™P(VŠÅeF¯çRƒu �¹×¸<åš?žÇI!(Vïæç%¼®—•ŽO¸½žŸ«‹£vaú B¬æ†ã´ßnç{G„¢¤¢×½Ê1Œ×ý¥¿HÔ@PÈÜÚð0ï¯¯(1N²_¾=×eœ‚	…é¿ƒB·ÄÐëm¯nÒ`"–>€ë[–éqFÙ>¿b3!°ôO@ˆõ­´éqF»=_21¼{ÚåùãÍ-±ûF¦÷ Ä¸×ê–Ã½|^¡Ct°ôH–»�Ãøñ~¹„q€“€Òm¥&¹·sÉGÌ*–>€€´Z»{ŒzÛž/ËG
Ó„X_‘ãØò}ÏqÕQ,ý:(+kž¦§öñr^—0yÐöœáßËËöñyÓa6±4ƒ³Übëë¶û0k0K
¥÷+ÝáÑÖûK¹ò0{j¦ß…ÂÒ·p|óêõyãâCX:€Bé­´qYÀÛ¶Â¨béû ÄzÎO�áv¹Ýú¼ø�KÿÐ¶M§§±å�·>M“’¦?!l{©z:J//÷
ÇyZÜýòÚòtRéK@¡4ÖÞ½Ý_Ïu/ÃáËà®?ýöù†Óø6—~ýx“ái&€í^9.ËzÛ^VY>4K±¶¸½|zÆ´¡C�ŠV¯âæ73êí~ƒ”J±ôk Äú}kÓãóåöùgë»ù4eŸ…iVsÁò°L¯—ë­É4ú¦°ô{ P¬Ü»�ßîŸ^æ¸ŒPˆ¥ï�ë¥`šž*®—Û!ŒÍu�•žux3Û§ü¼÷Ãp„&«kuÓÝ·Ûó¹ùarµôö½¸åÃãÓóåãy[Å�CØËó§»øå@R-}
µ?¾{C»þì’ÝãâBU±ôA�Ù^[˜ßÄöùrÿã<DŠZšA�Õ\t~<o·k.~zx÷aþüÓâ§e`£2ýGP(•óÓØûöùn2Ž–þ³åy|´ú|û|�_¢ÔÒw@�µuSÿðnÔÛùS[ìäµC Z®5,OÃ=_¶}ó£šƒ¥ßYnš]iÛ-ç<“‡µ½jXËv_EcpJI_�këæýãa�ûåµôi
&éG åR1,S9ß¯÷Üt|G¼lŸ>Õ6„J3ÛãôàzYoÝ¢Œ¦"éKP¬ÞKŸŽ±Éëë¹¶~X	Ë—ÛkõÇÃø0Öóúy/ú8¿…o×íå‚1Ž“ôK í=ûðæ \?~î=Æ(]$}
kÙéNÓ)|Þ>_8êà@•ô/À^Ú¦ãƒ»®ßÞ.aÔU'éö\››-äûµ¬Þ�pÔt™ÑÄ?Ä-—ó­‹AL%ý Ö·ZÃÃxÈûí’uG5Hú§`/­h|3�çõœ×Ý(ž’¾™Y9Î®Ö|¾ZžÜ(*’~d¶âõq8æËå~-“ÌŽL¿	Z1¸qp½lû
ŒÎGSI'ÐŠ	†ÃÐ‘·RƒFQhúß Z.ÙÇwƒÛ>úzÓabsM{šA¶Úk˜çiÈ÷ÛÞm>˜I:Ál§ùq²m—ýî'õ¢éçÐûÊdË·¼Ê4ér~ÎW?�£”ôhÙã<l÷Û^fL%}³\ªNKyÝÎ—Í†b«µQŽÃ¨u{­ª Jú}°·Íu¿D»µmÏô%È
S[ÆÉZ>¯Á\7¶V£Xßs±>è<xí–ï° ¿L·ýÊ>Bƒz@Ò´¶Ãdñ�Øö^½9õHúÖkQN~h­ÔÝè½:I¿²ÕÞÂ8smgn=n0($½�{ïp§)²¬·,Ktcs$� ÍvÍc<—ÛK«“sŽ’~½g³J»­ÍœwÑußÓW ±ô*vcØóË–d \ší~u»•âÜ|€oyÝJ[P§]$ý1Ìj!ý0‰/yÏ]}œ¦ˆ¼ß!d4¥€Vºs5_!�qö÷|¾eÎá}ãm¿;ð�¤„±—Š§É,¯WD¸(ª]$aVàœc³vo@pª‘ô»0VÀñÔ½¬Õ GÀŠnN§£h.Ûý(óìÝ½nkéT¡I?I+¬Ärµ®×-c˜žü¸]ëeßE†
�¤ ÂhÅ•Ç¨èÛ½©Å ŽH` {-´8FH¿˜H”Hú¤µ�¦cZ+¹zïÕ{ÄZÍÊqp~«—^ Á˜þ„Áz[ÍÇéàj_oÝœ�ˆ&BHŠ h½H�›–ØoÛµ¬2ž–)Ôõ²²:8@i5Ã¹ãäl_o—U£�kYjœâÄ½ŸKŽ£ŠM$LØ‹VÆè÷vÉÍÃ1ŒÛºßo]E‡îºUÒßGò”Þ‚LÑ[µsí$B’þ5ˆ’µHâÔëvEwˆêà(’þ3LHa«C8¸®·Ú=½*! iÑ¥ª ÷Î³hÞoÛÚ‡éi}¿VøÜÐ<…t]$=À½·]$Ì£˜Ýª©À¥±"ÈèçŽ½Ü;œCTÓn¬B1ÒÚ­à€’~4 Õf2NÞ÷Üî] ê´‰€¤’F!¬¸îÆ!HÞ6ÓÕ‹'(éˆä)FaqYtšëëµ­£_µÔÕ;ˆ¦ƒP@I¿ÂH
ÙkW?Ee-»‰I¨Ð¬µ&>X_«‰ @ÆVáü0‰æýÕÜ¨‹—VÛÞ*5F­ù–3!¨ˆ°µŒîbôZÚ­gU¿ˆ¡ï¹Ì‹3…Bh�½—C€Ô’^œS¦–þ˜<ˆ.½P†èB¶›Ð+”•€„é’§ bÅu~‚ÚÞJsô"B¨F×@!@F¡Y+@XT˜ûªÝit zgÍ¹\±Ò+ND ˆL¿Ò¨éÅèâà¤o¥QÅKh Q	‚{5èä€VîbÎY¬#ÕÒoÃ` šõf8²WfÑ®ž¢$@€* VšqpS‡mE<�	&
@ YvÑÃú¥¦ið¥Ü®7ºù�•¼ï7ÕeñÊZ÷,="
•L„’ž@önÔà!ÌNFï©¥wâÄ9é0‚"éHv5qJ«ÖÅ�Ew×µkš$ý-Ð¬Å;ñ=Wäƒ›ek»(¼Sj¡“0ý€F@Ìz§�¾ÖŠ0X ¢ö¬Å…´×û^‡!�{i/	1Ò 1… (  –˜<è°N¨s¡³W3…ï´ÞIIÂt€Á:^Áj­	T„031Å¤ƒ´ÞÉ{é9÷»ïºx›Ýú?¦nµîU‰¡f xñ=Ã›úàè{¡�ä„ÉƒT:L¡ÎwëÍLDEŒFŠè„‰¤ƒ  Ië¤‰—dßµ7G'ÚÙ�öÿOZX/BASE      A  xÁA  ƒ°Yãx` þµ,9[EF¹ÚF´ILsd-œÄœ‘r3Ø\Òk¤(k&E”Šm-)r�Ê\E-50†èšj­rV¦cå¬µ–Ëm‹!VÉl­¤‚\3BÛ&M™lb
PèÐˆ¶l.$² 1€µØj®­XkQjâŠ‚MXØºZ¨ÌÉª²Ð‚Ì´” †b›´ÍÉJL§Q¹ 1†l–l": •¹„k‘bsÅ¶U®œ%âb±ˆ…”ÃV¥VC#U"&Ë[±Ä1PBZ1¶Õ´U.™¬\äÚBÛÚ¦«!¡Œ”Ü$‰Á²¹°
Qu¹1'H±R%8d“æ\©ÄÒ ¸™ÀÛØj)Luåš¡Ã ,gÛV8‰IRÉ¹UR·µÉP]#üBPOS      /  xÁÑ�@ ±€Qöy6A:â‡¶(ûï¿?ß�Ç÷ó¼¿Ï—Ïs¿òuÜoyæö<ëör�ÑÎµÎ™÷=ëå¾îr×zMJ;µ÷&5eu˜n™ÛîZ·l¹mÝQvÔ×­Ö ŒáÜŒÊ¨¥%Àh¡mZÒ&‘a4 qÄarÈ ÝYÀl#3C# ŽËFÁf m"ÆÈ!BC³™ÆdZ£iFLŒa›±$­˜Å�L¦� ��™v'hiD¦©Z 5‹dÑ°ÈD&…H“Ò
L-2-±F &@c ÃÖŒXc2¶ƒ˜ŒaY[›ÍÌ�ùYÓ²0ÛŒéÜi6ëu÷ã°Y�O¬Ùì·{ìý~ê|zvûòÜ2CNF4      /«  xÁQJãP€á?¹9IStªt&(_\ƒ80àÜÕ,n@„¾†L­´M›œÜ¿/y»}IÈ Å‘èxðtš¤b�ÌàüÁ½óÙ>ÿ}¤?‰ÿ¯5ÃÚZ…f¹¥:pÓB&Ð°úWk†	Ð@­+Lô‰¦Öµ¾bƒ
&êè"} ]ðþ "A×Ò•&º ƒÒ@4££:£0�®1¨!hIœ4Cøº4DsŒ®´°›Ÿ‘ET,M`³Þ¬hï6Ä_ƒIÙåÇéxöÜö¶ýÉ>ÙCræ-È×�Žî£0«.°ÝŒóhÓ˜T‡ªwË)zÒ‰BÆ9SšEìRR/Ù³d{�¤ž�ù 2ÂIuÔQGuÔQGuÔQGói—“YTEXT       Ø  xÁËn‚@àÿQÎÀä\HX—Ø†‹QÛÑê²±‹¦‰oßïÃÇâÔ!xß÷b%œqÒTâ3MöU^dÉZÞã8Ç²sYNhãÚáò¸“�×ñ®´¢Ôœ”Ué÷I—Ç�Dh¼¾ˆCé}É�”U±œ¦ÊªìEï¬ÐœRRVe/â8xÏíg7£¯7ÆÛ|˜ÃV·ëŸ¹ïçclÞ`ÁøcHÍ4×”YS3Í5eVŒ‡v€cÔMÐ×îöõƒs·¼cœ»EÑ×$N�l7ÏCLIP       	           l     W®ZTR

BASE      A  xÁA  ƒ°Yãx` þµ,9[EF¹ÚF´ILsd-œÄœ‘r3Ø\Òk¤(k&E”Šm-)r�Ê\E-50†èšj­rV¦cå¬µ–Ëm‹!VÉl­¤‚\3BÛ&M™lb
PèÐˆ¶l.$² 1€µØj®­XkQjâŠ‚MXØºZ¨ÌÉª²Ð‚Ì´” †b›´ÍÉJL§Q¹ 1†l–l": •¹„k‘bsÅ¶U®œ%âb±ˆ…”ÃV¥VC#U"&Ë[±Ä1PBZ1¶Õ´U.™¬\äÚBÛÚ¦«!¡Œ”Ü$‰Á²¹°
Qu¹1'H±R%8d“æ\©ÄÒ ¸™ÀÛØj)Luåš¡Ã ,gÛV8‰IRÉ¹UR·µÉP]#ü  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  I     I®ZTR

SMP4      D›j  xÁ;Ìï[zôïó¬µ~×ÿõ}ß}�ÏœsÆ‰�Œgl#ˆ=vÄNEñ
PJ‘H4ˆ††AAJ‚jÑPP !z �*
DÆŽÏ™sö>{ï÷ö¿þnk­çËç#?ý?€ø7AšúÊ·^uÛ­¶»vµ}y»zûf·Ý¿Ý~w÷ŸßþàÅ_Ü|þúí›Ï¿ÿÅ¯}ö“/~ôk¿ý—à¯üÿ\ôøYlð)VøüìgÀ¿àïÆïƒ±Â&ü,~†ŸÅþOüó‚
|øü³ÿë_ÜÿÙÿþÏÿä_|ó³?ÿÓ?ý³?ÿø/>¿}ÿó/?Þ?}}ÿþãÏ¯ßïÏ§áp:¤ašsN)“ŠßÅÿ
û™ýî÷a¿H•4Ó"$$0AÒ„ÐD …8¡3Ìh0ÐH �, ‰ˆB½¸â Í¬X1�TÔZ „…4„@B°ÐX Bh¦ÅÁIï˜-›”B�3€08ˆª 0ƒfFÂH+	Ò”&;”’K)@	3`PQ
€bõRC%”œÒˆ¼N¡*¥d#4(Ä¸¸œ)N}!’¤qN%ä’Œ­áàrZ8k6P*øP¼ä¹H�÷ŠÂ<Zqðµ@$1MŽ¢ÞKlAA±dd¼Ïó48€3ÒTjç\<ÛZasb•Q¹vöK>zøºjº"Ë4[)5Å1¾ aÌJuA2—”K‚÷©Œ)0øÐæ)¾î”KºBB'ê)Žñs´Ä) íJ•ÆÅ´R›š–ø
²Ì(®ªK—å"S«AM<,qQ×£Òi¼z§ðN°Ä�¾nViJç<Y*¥ÏÂø¯ƒ@–<ÕÒy‡¼$ÖZ¼ÕfIQ«Óœ²e¡qBÚ"³s«:¤<ž/$´Ú\¯×ã`m[k©Ìâk —<;»uÇññÖµ¤Pâ_(Ëb¾]¯Qãuv®ÝTrH§™DÓt’ã¹ÌuÕ*E$þ/ @›ËÜ7w…§§‘Ö¶•éB�?.Lp}[áp>]×+çu²L+WSMâ
È|õX¿X­šã§·ÛÞÏÑƒñß)åTåîV�Ÿ®Ç.ô­ÁøÀ|)²z¹]?>ÞÏË‹U
¥@ã@ˆa.V½KËóu*¹ÝÝv×Ëùý(~å™'V»»µ|õá½qU5»Zpy|¼4ÝºbW ˜¯VßÞîçç??Ì¯7šRBã�*6×ÍÍ‹ÕÇËû+÷w�]`ü=@'×l7îñiêjSƒ„A%ŸËÙ½Ýãá›ŸŸçÝ«�qPb‚‚yÉõ‹Íþøðø.•›j£ë*žŽð›¦b¿ ”qÉíº»N—C*¥ÖÝÇûóñŠUë$ƒ¦óµ`÷ýïñéÓWßT·¯ª”a`|*Óå¡yóù/àÛ÷¼~S1/Æß 0ŸÙ¯nj¯`×û’Æ70-RÒeÜß5ÓãñiLÕ¿X10~
€…©Z5õ4=?-mÝnäå8äMÓÃhdüÛ0-Âá¼¸»‚çOîÚÞÆ,F‰H.§ðâ;aþòÛ¯Î»í^æâŒï@ªØ8/þåËý»��åÎßWÄ(ñ€MC]í_Îã‡Ã(°¦m
¦ãp(@Õí*œŽï¸®B¤Jfé67àó%‡›®UƒQâoÃÔ˜ç¥ln×ÃÓùqme42v UÊt­Ü‹m;ïmÛÆKJÉS^…us±SWÛÖIc
€”²v›ÙN×E]]š¾™óõt-¾niãajÌËŒ»}½<O‡t³
F%¶ €<ç²Ý¹ó4œ|µë  `Ãå²~½Yç÷>¡Þ·œ%~R%¥©[?MOÚ¶Z÷àøülh*F‰
ÒÈööe>>ú›meÌdüC¦–Ÿ®ìÿÒ_Æ§�_½ÃæõÚMÅ‰/@P�®¾º¹	éòt8 [×™™ŒŸ�+KÖÐ¬Yæócßõë’¯§+û.ÀÆ¤j×ì^¹ëñÓÅ­«U¿ ¤2·›¦;^®óÒ"4»væðtÀªn×��ÇÃ…¬[õ`üo@@Êd%ì;åå<ÕÕJ=	ÆÀ|2·¾­æç‡oõË®RÒ(ñG`ô˜óu×Ýb¼<?MvW¹¬FÆ5ÙÀnõ
r|xººÛž.+,m+ŽÓ	Öû`Á,®@ªØ¸äjû¦-—¸õ{`ü`é
®o0ýüñãi·Ýa&ã EÊt™Ãí÷«ñðáÝ)í6~1ã¿	‚;âx÷ö-žùâÅRÄ(ñ7A eÊm½©l�s]¯IÅbF�Åæj½W;�Ï#VM]X X(]'iÈ³v­JV±ø
¦v·y³^Ûñé\5ëva60¾©’Ç¡i¶»€Ça7}$;˜ó2\÷ßíîÆ�ßL²»]-ÈÆ— ÄlÊÐ�ÇõrÊ¥©•Z$þËœýöÕJîï�›m_Ï¤QbR�ñj«ÛïÜ\>|:}²›�ËXŒkP ˜9¯ûMÆñ8—vÝ)µHü50zäyÔöE�®§Çá¶ï–ŠÄ°± Ù6§áò<{„`EÅb’8ùæf­ó‡ã ¡ó>VHrU¿Ò\.å ®�7±Øƒ"f³Ø*ô¸ÌŽ=\Û©[Ò%³kj-"ñ€€”|r~ó¢KçÇçÇõfëµ ¤I›îöÆ]¯§‹­º¦/ÿ(i¹Ìýëz5~<LõÝ¦ž!BÆ  3sÕµ˜ÇtLmÓJqbñWA(Ï§%|ï­?|ùnº½kÃR Æ�IœÕo+Øe9¥j³ñ>/—Ã€Vo^,þ–2¯šÛŽÇSš°®=ÄÑâg @°¤¹k6›2\NS×V³ŠÅW  6¥©ß5àãõrêêº&‰Ÿƒ"V–¢nµ"¦Ëi»Ð·–Çã\Ú]²‰?HÊ×¿ùÆ÷÷�yÕm°X’ø�Aˆq²R¯÷K¹ž.¡ºuâf‰=±´mVípººP¯ªÙ®‡Ã¥é´jî§ËÉÍ¨Ã>tåÓÃsZëºbV±Ø�K\µ¼^çÌÎ×­ú”†Cjµ$þ"ŠÌy7¯×úüéÛ¯²Ûõ’ZüP œËV›0^�s.¥íÔãœeÒºîo·<]��ƒÕõ¶AýxyduW+­Hü)=ÒèÊ«—ýÊN¾}–¶o;˜cÛ8 a™`mß»4]§)WÍ®uv}œ§Ûj¥’…ÿ>(ËÉ»Í
óñxuÕÁd‘ø„pÆ‚ÝÍ®-‡‡ÃUm#Æø1aíjãmºä!´ýª*×ó5O•¬ë]�Ž—á|Bh} ÄâƒAš‡ºÛïóñÓáÂíf£9‹Xü]Â¼\}×ï[Œï¯y¿n‹¤j®ƒß·Yæ¯ÿâÝRÕ+aq%þ@RNÕæ¥,çOß<øzWq4˜/®iök•ÓóiÆªj&ZÊœ|Óož�cñnµz¥áx|šÛ¦@‹(Â2—º6è<�R½´´(E,ŸóÔ¿øÞËÿAþâð°]Š8‹
Ê0æU÷b½™Ÿß_‡Ííªñ4‰¯@�pœÑn_»t=}|(ój·]ÕOÇ‡Ëh#Äâ¯ƒ\¤H½½^Kj›F(J‘<MK·{óúÆûwïpÛ­]FfümP
'Ö››º~>>>]lÛ4¤–øPÄÊ8£Ýõ«åÓñx�ªZU°ø(be\P­öšæ‡§SéS¼Ë*ñ5Èœ2\ççt*OõÔ{E€y—úõ«W˜¿}x·ßjI %þÄÒ˜^¾¨pz÷áŒ›Í
K?E˜m)õºíË|M§¡YïBÓLÓ±,­J–øÛ  e—þåw^òòøþäíîµÖ3žæóè6U£Èÿ:(Ù�é;ð4¯¶r�AŠ˜MWu··ß><|{šê¾vÎ¼Ä‚¶ÌÁÚÍ8–®4UÈ_ƒ"–rÉõjŸ­ãàBU©$‰kXYhµß–ñR¬j¯¦ñw@‘2Û,ÝzÛ—Ãó9lëNœYì@�h’3t·¾YN÷�‡+öm¥ÀRNµ[»þš/çÚ•Pˆ‰Bâ¯€6jÕ»°ŒÓ`¡ÕN4þhÓ,Ø¾Øop~:~JÖ¶Ì\üUPÄò`¥Úx¹Øp¼T®®4ö @`Ã€éîîÝÃýÃC[íV•.Ž�¿ BhK*·ëûéãáø¨Ü®nö“¥ë¼,KS‰ÐXòR‚ß¨Ê„„ë~µÍí§å”–¶•R	-rßíÚçã;Îë¶7…±�¡äÅ‚t+‘2^æÎWR¼Æè‚%UÕ¶uãr¾¦ß:µìJü» HÉ×ÙWÍ+7�žæé7µú²ðVÎAšÄØ‚"LrhÊn³æóùÓõ"¾>©™åê»Ðè4ŒZ±ÒÊ(±‘m)R÷Ýt=¦¦	ÞeQÍ¶,ÎÝtÐô|þÔpÝl*‡Ë8áœ ’"ZÂœµY­Æi>hº®Ñjg‘ˆÈ”ËÜÔÛ]�áðíyÞK«žâŠÍ–}èC•çË¡®g°ÄÂÚUÂiÊ¹íVë`Ó�­47+Tó5]‹T¾V_Â4£ênçëóÃS·ïªj*®Àø› —2‡°ë›êãñ²¨Ûõ±ø÷@²”¥ÀÚ>xÎ‡<¹Ê·J¥Ä[ÄÀ’Sq®õ…K�÷²8[Nê+ˆI*¹®Vm¿|.RWÕ¶ù2�C‚i(ÅÏ”øÛ 
)ÓÂÐ®÷MßŸ‡}X;'°<UÅ×Ö]l˜Å9­	æDa˜ ñw@#™‘œö� -£STÎ«8Bâ/€d²,¾î�tNÏ«N+ƒ$V0�å™¬›Nüx™’L½º�(o``É*ç¹“H­|�Äïƒ„sQø¶ª-�—ÉûUèe±r=¥¦ªW"å:,Uiû-ÖÇã®]íŠBD ˜°äqrÚÜ8ÈéðþÔ¸MÄD qšeBÊR¬j×�Êsžµ«j'(šá q)´”�ØU¦i²ó"ÁkAÉIÌå¼˜ónëýe:Ñ\U9—­äLG�B4þg0h‰#¤îÄOÓùy¬BµñÕ`ÃB	}	°ŠB*@.•i±2’¡U0-hÉEº&XšÏæ�JpâLT€‘³”Lë¦wrçC
«z[ƒÇézq®j7Î–qÄT	ê”H’´òb™Ë¢tÞœ :|ñ¡³Ùòƒ®ªUì”ÏË,¾¯»ÌtMWk|Ûõ°q18qAŠ¡…”¸Iƒm�ùªwÎMgäN+U³<©ÒQTâ
Ò(.R×†4€¬|-(.‰‘€@H‰¿cÅyx ›e…9uPµœ_U€qfV¡'0¡Xüe˜Ð`%'W‰äy,a….ÀRZR#Å©@ÂÔâK°X)ª.Ð¸@çM-[&.¾AÒòHZÝÆùRŽ�„
0³‚F¢2g)ÍuM_Ü2Ïlë¾Ñ2§¹Œ=«Œ´˜8%P YŒ�•’³4‚d‹™3oa"pq…•zW8ä©-.€`’äU‘è	HühVr1­œÊ\.Îµ#˜I�pE4þ5ÐˆYbÑÆ×ÈSR¯¨ás13B•€ `)™ZU çkªJ°p–PT*E”qšUIƒz
lñÙx“”ˆHü;0Qˆ•”Ä‚ïÓ4Ã³rªf¥@T%®@„ Y1£¸jKt®u’æguí‰ÙŠ…"�[—]¨˜Ò¬ZßV¢sZR0ˆz³-`'^£'T!´ø}iÉ˜Y¡V`*ƒCôµ )å¤IàE¨€ÄÏ`�0ñÎ‰ÒfHapMoN¦SzÎ>¬7Þ1-Sð¤³  F/0‘èAŠ*Æ’‹øJCQKœƒHHb’`¢®(I…ê¥&3)uçÎ9‰°A •dfj¥„£e'uPÒFâé(bÂè“8yf"àœIS£ÕP E„& i„ú jy1E€g)Ì!˜SÉ,$$þ$ ‚B!ÐH‚"ÔÜ(éÅW@.E:%�
xæ¥hFå¡‚TtqA³”IþþÇÀõ¿äÏ~ùOæ`f0£˜(TD@
‚4ƒ@H!@4ŠPMéU#Š±’&Jˆ˜=�
qêBqâE˜-/,¥€¢"�D
,„‰(4øìAX’Es1ƒ@UD@LÔ�!&€7 ã@LˆÅ Jô ÂÈÌä�X+ 9�VBÑÊT F!!& 1@,vÒ,—B©¬1·¸Ét:8ªcü5�%'×T¡¤4Q;“Ê ÿUPh%-¢¡R±²¨g­ÁÑ—øA!Š.V»U‡9_
Ùº %€ñs,y¦hÓi^–©XU»@5-ñA!ËLe]59KÉ�¨‡2~
QtçúºšË5�lµ W @ T3˜(-V mIÅuM?_ÃTòJŒ¯A 6[FØƒOçç9í«¤ˆÄ
,q®ºHãÕÔUwëýéáñ„¹i6Û}s>=^i+G€ ¸0{¿’:Ÿ¯CÒ
z³ÛãáøDÿ²i'-
Æï€Â’L\Së’ç¡ÕJšEK|(Ëœ¤¿‘‘Ïó4ôm¿Zù2<Onßv® Pæ‰¢[ºr¹&×Øzµiäòô°Lëõºªq=>ÝŸê¾n…[`ÊfmÛ\q>UMh�˜‚±AÉ2¶Õvcy:ÿËpÞNáöe—¿Î²«\w³>½{7t}µ½Ý­�¿ý2÷»}ûêæÅåòþù¸½ë]&‹d¨$Œ�¿]×Ëù|š‚/ÝÝÝ×O�iò}÷z·}<|ó²é1€ñ' UË°ØúæÖÍÏÏgw×¨e€±±%-¶Û,×ËñÃ¸îÛ
‹ˆÅ?£Ç”¯ÝÍ¦õŸŸa»u£`ü[`ôX2ºõË&Í�ï¦¾ ÞÞbzÿtêfÓî;o—wŸ€Ýš³Ñ(ño€ 8]µ{ñ¦³ëýñäÝ.c�X¬¸¾¯Ï×çë$óþE·�¡ÝÕ‹e€ñ�ajÌËXuû‡ççChúÖ“R ñ%HÕ2¾ÝÞuåãý–5ºUÛ¹ÃÇÃes³±œÆƒ &›Œí‹µ|s<Ð­ë’Æ¤¤Öý­��§Ût±ø¿�T±a°íÍë­¾ù·YÍb”øS ÓÀú¦mòðxV¿( ã
PÆÅš[øqxž58„›ïnÆÇŸ¸AØoo7ßÞû!loûB�ÊraÝßVýÓñy,»¦
¹¡ñ‡ €åäq³rÏËãÑ‡Û’Åâg ¨©Ì…ýw0ýüñÞlÝ;Í cSc¹mó–íðpš»®o<a”ø  ¦‰ëö®q§Ãã¥[µ`ü	 §äšuŸ–ËtuB¬—‡§çeßy#Áø+ UÊzó¢¿9|üð±©º®Øb„€åŠvs{Ç§ÇËÉ7õë­ÏŸ¾þº`_ïn_bz8~�®kÖ«Þ>\Ïûºé7Ýêúþùcµ{ã€ñ§ å*x¹¿Åãá9OmÔ`”Ø�TIiô«½bz>±4M`ü §eÚÜ´pOÃš&#ƒñ? bð�bžÇì(õîe›ï?¼Æ-ºÕö‡OOèW+?"‘T0eó«Îòx}*Ë‚ööm7=ýp|½ÛAŠ�ñ5(XÂ§�½¸YŽ?<Uo[»�œÅŸ‚+SÑ¦«sOË2›¬ÚÆ=žÞmÃfÛûO§ëqUõÞÑÈøL�9M·måøt¼¤Uh#?)sJaÓãé8UR‰ßoûëÓÇ«ôu#È ã�TIiÉë5ÂÃ0\m×z·ˆX|	”´Œ~ãq}~<ùÕ®yµ®Ïç÷ãè_´©ÀØ‚ mœên»kž¯/y»ª…0Jü!ˆÂ3òöÕ
Ç÷é¾³Bw‹Ÿ�TÍi’íîå<=<tÝz”D‰€ËPÙíÆŸÇÇ‡‹V½;�*y˜ü~¿«Òùa
7m;Kÿ¦Æ¼Ìµß­¯ãé<5m[1«XlÁè±dô«ÛjœßK³
Z@PÀ<[è{7ÍÏGø¦Ò"Ó"¶ÓþEçŽ>L>WÛí‹÷g¬6Å1Jüû @Š\Õ­zž—ñd]d‹ÿ6(¹;bÞîWx:?Ü7ow§ÛQ,~bsën[ax~ ½…¬b±!†´Û®PžŽ£4ûN|V±øÛ @¸k»Ê†kÊÖÔ",ÿg¤ªkl\Ö.Ð‰$aÐf³vO‡óqY·> R (×«_½éüøôpEÝ6µ äTJµ¾�åü8]X‰Òå4LuûòÖ_Ÿ?¥ÃÊ­6»¾><]Ï~G‹Ÿ�CZ\³ºÝér8ÖU]Š(œçb›Û½-C…º[ï5]_g®Öž¦
”ëàww7˜?=žöÕnw·«–o÷~mM½­ÃðéòñT¤Zo»p¹>>�]¯RD,þ$qrávWÜýaPÙWªÄb
iÉìvît=Íãª[yWœXü§ ˆqÆÜVUSx”
R•`Á4k³ë+œÏïÏãzÝmjÇÃ'Øºm¡³Äƒ€¤2a³Ý4<ßß{Ý­«‚"±!–/5Ö›®žÎÇYBœA,þ„°¤Éuí^Ë§óaì¤Ue‘ø
–<Wý®’Çóó µ[ï¶­<<)W›Z ±ø7@ˆ•q©êÛ•;^žOãvßALÅâg Ä�ÒÐ®ö•{¾~Êh›F’8‹±2ŽµÞtM¾|º>£éE@,Kw/úöxÿéx¬öa}Û«½;>•êvÕ¥,J³±äpS÷×ûñ2†¾Yï7íõrÊÞßuý*Ï‡ÃivÀ~ÕWy¸K×v�„XüP XÒ\o·;7Ïg×5!ˆ)E,�s½^­Ûóp¾Î¾w‹¿ŠX™É¦nõšÎO¾	•f‹)e©;¤i¼œà*@œÅƒ",Ë<ôý�ÍÇó#Xí›Š‹ÿ(beX¿íÝt9B^‡ �øG ˆÙ”­n7°óiLµ6¨’Ä_E¬,Ë
[W—éù0kU	!ÿ	,O¹Ç&8<O¼´ývûB†çÓù"7a7»âã±|ÍK½[ñér>_mU©7¯ñPÄ–2…¶ïxN‡C™úí¶o9��ßœóMW93`yLê{óxIVûÊI‘ø)e µ] †ñ�Û¦ƒ/ÑÃÒ’:¿uÃi8^jç;H–Øƒ"¶äÙ6·ÍºÜ?Ÿöûyx>§Î¯Zq_ƒ"e–¥¯ú:ÌÓev¥Ê0«‘K^ô¦[N—ósíª.;‹¿–e©Ð5M:ŽOiYK£B ,ÓàÜî¶iü8qU5•jÆ× È"ƒømç0 $‹
mIS¨o6U�÷ÏmÓ´¢,¢ñ(’'fm×ÌS:>U-‘%®@‘’/Z5/6~>?PkSA³0þ*hKšªîf�ét˜¶u+J‹�(n«~^NV¤ÒìßÂÊ4WÚ¯�æËáR£­œ+ÞÅ5hK.Ò®V9�å*�ki¢ñ×Á²˜¸Þ­�—ËxñR¿Ø÷ùñôðèš}U›…"˜fmš[vÇûÃ#šêî®©‚�ÇIº*HñÆ‚H¹”¶Ûn¦ëø4ºà;óYdYJ	}SÎÉ¤qÚ˜3ÑøÇ Èâ&Ñª]°ÌÇÔnö7‚éütïÒ~{Ûc,‡ËuÜtMˆ˜�4é6u£Ëi^ú¦ªBvñ(Ròuªêõm)Ëùyð}ïƒˆ‰hì@›-Õý¦]¯§y°¬wµŸq:Î”nÕÍw`É³JW»’¦Iç ñ_�å9AÖÒæ|IO¾•JL4~Š¤\¦U{#ù0\‹®ªŠÈ?)Í�[‡¦Ê‡ëñÐÖ7ûê.ÝßO�Ý]ßˆ˜cì@#-Ï’]Õg]ædÒ •“@�Ä ³	³oÚ:\äp~]uÓe»�Ï¶`»Ýtît¾?p]oJ‹¯Aá²¤ªÚt)�§t&·]…¬ Âl)‰]·n�ù¹<ÀÐ¬÷¡ÈóutÖÕu€?‡Ù”¡­9ž—ajšýM5>=@iÖÞQ)_ƒ–¦Ànšú<ßc@]ßÀMÓa:Áª~ï«Ãói€tÝvå«åø|”ÐÔUe&
Šä%e_·~’a0™µ†‡)Ïlû›7<¿[–Õ¦k1‰w Ëœ)Ûv5Ï×kNaÛ8-®¤ÉªÐ®4Ÿ/°zÕ¸áéýý»¹ßoa’Âøc˜˜—"§NÅ-~V! €MËT­Ö±ñt99lBÉ*ñAËC¶°jWižMïƒC–¸†ÙLÉM-NÇŽ�s�„¡Lœ»Ðõr:]§KÕ¸&hq*ñ—@˜¥’Q×7‹çõ”¤k]ãJ½Ä_™À¥Õ¦^d^¦ Ó
ª" h9Eæ��®ö)-³q$˜($þVòB!äœf· „ì!ñ�.š }]ÓÆ<ç®öŽ�ø
4–±¨6ëV–ëµLU[i�	‘ø˜ §Y‹¯µriœ©´kš‹�×|ÕF]0�ªÄïÁˆb¶Hö®EZìBóN=  W  $Xn}GLËe�Ù­›}ºÚeÄàœWuU@ÒÊ,ÅWÍ~ÌãÙ²Ó*8S@`ìAA+eu]JžÇg`X%u–JÖ+¦ñh}€·`°’˜]¨•–' õ¦â¥ŒÇålêµh�Hü-�FšM˜Z¿®4ÍÇ9gY¯´æiT\°�&J€ 	XÊ¾êœ‡ÓTsÛ­*�æ‹yí¥†ÓB1 ‰DQÜ\kW‡1.x­©HÀœfEÛ¶ÅÒU‘DJ( !dô ÀÊ¢R55È!,µ¼!ñ—`4
|dÖÁÊ”Y¼•‚Pù€tu®	>d–I)ŽÎÀøWÁÂõ
›•hj™—Ù#ZyñÊ’Š‰ˆ¯T ‚ #H
B¢,.™ÎeÎ%|e"ÉX@$`üO@,	¦Þy�Ó<5â„¹äÙ‰â+uÙ†œ­†/E`y"éC›¦óá´øêÆËi™rjš®aÊ—"$P ­äÅû®¢Že©©’€˜–X�ñ$H>y4.%Ñ«s
3Ëi)ªM]MVf†¦ªÔ‰I „R(ñ÷Qh*êœ’,(¦¦1QŠ� L4¾	S
­dƒ×¦øTÌµv%Ðf_
U�	(ñ»0!fˆ•«§¼\Q|ßC�òä­‡Šâ²A-Z …ñÌD–²/Þ‡†,WŠoCçe˜'“ä›F,•9ëâÄC¼‰%›QBöf9¥L8©à ´ÙM®x0[RA€—ºVHƒÐe¡4ˆ‰Æ_YŒR9Q&£‰WW¬$)âUb,z”�¶iK±‹¾mëRJÊYé¼i&3A0Âe,‹óJØ ÑF\fžM<œzB²$c�«èeI™Å!ÔJÍyV®(àÈ’LÔµp9§Ùµ¢C¶œIu�ø0�*â–�àY�6bY¡òA-q°Nœ+4�¨* ‚)H(Ð"¸¢Ì£
)$h !L®d�ÔPdŽ¥Ô³¢ðP•BšN”9±Ð{«,çÅeÂA B˜¡˜Š8‘R’˜4`KI©…Ö55sæb¬¥s‚%S�ƒ:3£‰WG‰ÌfÅ(Ú˜(r’ä¤‚yÍœƒ)ÕYÜƒªQ*s’lÎP ¥I!…¦E	@À�6O'ê(¤Ñ@£hm!É,PWÁY 	jÎÄ‘V
D�³ÿøï�¯1W…Œ„‰PH* TD‚�„�DAˆ‰€1@H1bÄ 
" c€ 4‰„˜@„±EM b@$zP„ E+P €�!AƒP¡¾¢#XrÉ%Mª……RL„Œ5(BÆ
 ¡�b $=P¤� P„ ÄDL  (B bš@Ä ‰x‚%Ï°ÐVKN9WA+�ø›  0ÔuÎ0.a®‹U0nA˜åÙ‹ïÄ›-ÉS5¨8ÆÿÀeNð¯o×øðîÃ—í¾_K-[‡ót²¼B#¤ÆŸ€ ‘òu¨w¯_áñþ«§ª{]×èÕ§ëõ8Î¾ES¼Y|°¹ÌM·÷ípz~ô›M+žã+.ãÜ}w-§Ÿùms×ˆÖ`‡“Ì¢5 Îâ
%c)«î¥ó×§§´l^4ºøŒ/@¡äe¾”êÕ�žžßÏ\c½(ÍO*ñ¯� Ê”Ñ¬îBsøöÛg·½«*g”ø[05–Kv›W]u>¾ÿ°`×b"�¤J¹–©ÿnß,�ï&½½•<©hl@±z)ÃcÆ÷¿ >þ?ÿ/pûÚæ ãïƒÑ#O¨W»[ïO‡kßÖ("dì@P$]Ë°þþÛêé›/Ÿ°ßnË‚¢Ù$Þ�±ñú,ë¾¾üó÷Øí»ëbE� (ãPwëÛîñøtXüºD4~‚�%]çí÷_ôÓŸýé#¶»ÛSZ „Æß ±yaØÜ®åðtš«½Ù¾ªw§ã}šªPU²iËãå4Àmœ"‘ñ?AÈ2sÞ|oû?=}øðám'ó" Ä&ŽË’lÿöx÷üMÞ¾éHP“×øWa¢’§eZ¿y†÷ÿòÿÜ5Ö¯öÞ¾~xÄ¶©‚ôi9œRí{£€bjÓiHŸ}þ]àŸýß¿|[uaí˜ž.�43ŠXæÐÞ­ªÓéñÒV›šŒÿ-„¤éœv?x±
_~y�ÍwûŒ:ûë|=ÂZk°�ñ·`j,×«ë_½m/Ÿ>ÞW»›MrÙÀø» (ÈGæ—¯ßbúøða	·®b\Ç1k[ÕtEbà2—²»ëó7Ç/uy±ñi”øû €”—zu£žrÓ‰ÒŒP)—¼ÈËÏªãÓWiûr-£Ìdü}�™–9ß½¾ùvyÿÕ×¶ÝmÏÉ ÆÏÀè±Ø6û0]N²í¼™‘ñ(³iÈõî;wËõÛ“¼Ú²$Ólÿ€ó\ñnÝÈÓé“ø]O— Æ¤Ëµ¤ï¾ý%\ßÿùÏñæõ~p	 ã_A _ËÒ¼}ƒÇO__çïìVLŒ[˜(x™ÆÛ7ßÝãË/ß=¯v]#Rs¯ÏZk‰?)”I†æîí÷ìÝý»G¬VªUp�—Õ¦Q˜X|Èih›·%ž/¹jV5¨Ù$¾ AA9–¹ûþÿß>ýÅ¡vo{×Òé|%Æ¾FX$þ�yœÜÝ¾OïžçÕjƒÙœQâÀè1ç›»—Ã×ÀMß`ü`—®ÚÂ]Ïãeµm½ÐÈø{ UÊx¹½s8óî²Ú4U¨p½<[ç¥ª*ÎÓ¹¾óšE,þç €2Í½¾h6Çñ9eÙjðm»äqÔÚ»Š&±©ZÆË±ñæî¿ûöþÛx³FJÿ]0z¤…îæÅúæééÃ¹nú¾d52þ„˜ÍT]Ê8œ¸	Š$ñWAˆ•ÙØíC5Îç	ÖxÍ*ÿL‹”e†|çV/_}ýxY½¸©¦�Ì&ÕµA F�eIKÿªkŸ¾ýúcµ½íÌ’ˆÅˆñšµïä4�g`Õ9] P`sÉa{W.Óqj}ç|èÈ<—
•PœÅ/@ œÇ!Üîvx÷ø!·7UU­ÛK9�¯SÛ“ØƒË×%õ»Þ>]à6«J@0þ{  –#N«7»ð|øê›cûÊõn>Ž©
}%~-nš&äÌ€äevõmœžŸÆ»¾1) $å	zûrýôíý)a·ÓÎ²¤e{çœ8‹¯Aˆå¡`µ^Wù0�aBñ@HN“öû�¤ÃÓ')up¾m—’/pµ:_$¾!†iAØÝø9=¼›ÛÛ&�"�'ÈÝM×-�O×úºm¡ÉFZh‹úÆ/œÎX”hkÕñ:'çZ‘âÄâ€"Æ9g·jÛóù|]Ê:„¬Eâ
À9sÝ¼jåðø)UëMcRÄb
€´ ª_9™¿}øxõÛM†‰?AM<–²ùÎÆ>|õtZumU5V¬\Ê ž.üÿÁK�®éuà{­çð¾sÕ®ÚÝn‡8vì"Û±Q%!!@	RH2AHÀ1 $`ÂÆ è�0CHŒðøQ·»{ïÚu®ï{OÏaÝ\WW›)ÏÅyˆ¬«!ƒäË˜B<yq6Ü‚€XNgÛÝ|¶ÇÏ¿ÄV@lø.H]g¤ãû}s~¼_à7}Ë®ºuZ´k£§ÿ„çÉš«ëm9?ü|¤w[×ÕÍjuÂÒ4âÛ. OªMã½ùá?ƒ€Ôu<O×_\ãÓÝ7Owè0£Ò†(b™«6MœË’­Ï�†Š×\´Û÷ëyœKÞ¹àaÃƒ�ZGqáúŠç—×¯aa2lA� §äúýoçOã²=õÕ?AHÊkê>ÛmÆ¯¿ùð‘7ï6®s\ó|N“zmv�Ÿ¦É´ë¢VG�X�¥¿Úú—Ççg¯\TÝdÔ}ìœ‡;PÄrª¶Ùwý<?"õ¹Ùl¶*—ûå²ßtA�Hµ$á´ÓÛëLîšÆL«@,ÍÈ§cË·û§¯Ç«�OÕ†[P LS’ýÍ)çoÞîäØ5M�¸Œ‹”�8±´Ö·îæ½Ï¯w_Ï¸Úl	†²ÚX!´s^/—ÆEó¦ƒG©9Çí¦/ó“yoÍ¶yžÞÆUMduÃ¿ YŠ¸¦k›¥Î„ÅUuØƒ(El7Hó|ÑÐ££Šd®Õ»cÓ.ó¥.qßˆö r�½ß¾S”óó2÷7A]–Ë,ºq(:ü f+¼v-æ4É¹`J…H®“ïºÛÍúzþ¦Œá°ÑL~ ZÊý®­çé-‘]EªÊð9h© ÛNuž_iðÁ‹¹áû H²ÜfŸ‘.oÏOmSª×ás�¥@º¦kKšò¢;Ù¡B2q›Ó!®�wù,MÓ(Ão‚LEå´{×ézyzaÝ6ú5OóÖ{‡ßKÁn+’Ò\-¶�Çáoƒ–¤Ô6D5K«P�:ˆºb×;0¿"emU†Ÿ€V&¨î$.e¬/µ•Ntø5��6¨O)ùªMU†ßEr]Øì®Ú2>=?jmûÐÔâê°E­KE×n%ÌëóÛ·êâ†,sr¾‰LõbyîÐJq6  —Å…ã¡×—§»Wô‡Cß{§õ’Þ‚w‘¡È°G-3Ð6}Je\Dw.hõ:ü1(S§w'ßÚÃýü¶ëœV°’|h yYBrâ$R†=jY
dÓ4º¬—…oûÃÞÊøüÙRŠÂ¸ nÓ"¥õ5ËN:HH+«æ&ÄèK•0×GiKÎçti�æ‹ÈðC�VS1†ãõi~:Ëaë{@Üð' ×š}³ßìÖ×ó8]Ð·ý¦OÎ9·ðA"U‡„Õ²”�ì6­,ã[®w{´s�æ×Éº&:8k®ÕÅØ9Ÿ/FöŒ ¸a–´4®ÙõXÓ[Îº“VM<D‡ÁluKß´~å\.sW¼PÜð' YW®mØ]•óÝzÉ[ß·Â˜dZÑ˜s�•e^cñâé	¢.4{R~Ë+ºM¿u—é¹$¸(ÎPR™öá]³/oi>ú-”¢�ádÍsõ¡iC®S©Ü2Jáp
ëœ¬íOm°õéÙ.ñÐAQˆ¿².pÖnaã´2%çkŠ?„ÁÌËÛ«ƒÝÍ	MM¬ND”Ãß…Æ²ˆºm»Yë„´q…æº,Q¼F¥måê»öåÓxžú¶iR ¥œô�W”læR#ÎÛp
Xr®±;EooÓ‹Cìû.bJë<j+Áw™ó¢}F�ó$íövðôð2–¶ïB‚Ã÷AZÆLiÛCßMãóý9ê¦õF˜­KH¢ˆÕ©_€¶pÙèN›šæóÎ6¾Ï~EÎk—£©Š¸Ä~wŠm?JlÎŒµ.3ºþðNÊz÷øÒðÔ7b�´)Í®;vöáéò�û¾iLªˆ-H®’š¦9ÙîyšÇµ¦¶q 2ü¬,ÙÕýî
úú¸<Í‡>¡3Èðwauºf×hç”²:ç-TÑ!€¨Õj¢ÔÐîƒ-ëË’zß·=0—´¨s>ú†’s±¯�¨°æJ1(`„:þH‚¤%'�©u]½@‚R¬ËŠ6o68?¿-e!¦VÇ˜âfw²qþøú´ÑëNZKuÍžèà$PdhAX™lÝ÷;/÷é~–.º(ZdøUÐ²TúÆ�e-€ªUB†´’Š¯mÓAÖ�‚œƒ§%3	›Þ]æå@ëgT "C¢–š‚¶>2—T«š:ok–ÜøÆ×šˆ¹Pb„”á„2aˆM+,ËbR¼ª¯^‡_ÁŠ¤È�ëóšLè�E¡nø� i,‰ª»í®Ióå,	Î{ÒU@uø)H˜­ÊbC¬¯%ÇÍNcZÎ&ñÎÃ„¤x�¿VTx•š`^Úªs©K[[Äª@%ÍPá´5'Z¸¸4xu11&VƒX™g'‘fŠ
L Ô:kÁ®Ã‚iÂÛà	EJ
®Ó€\Šë‹J$v i¬y!dÓ¶ó:¾e‡ÆÃf U	€€•T»nSÝ¼fm$ºX0
µŠ&ŠZ’CU‘×)´ê �á—À!@j]µøZ-K™ÒØïb�2üd­«’M»©:åsZ¶h¨
(:|<­²&Sßö¬ËzyÕ®‰ÞQ­&T@ÚàP1¥Œ ÄÕZ�dèaF@jMÐØ¨C~Åyj›&æš—´o^ ¤U#!�¡ ¨Uæ m�˜µb-Õkã•5UÓ¢P/1)>)b”XSµÕÚRëZ\ç¥Íš	(§RË¬5FX.6FHã”¹¦T›Øî*Ò4Jk­‹Å3
µ2üCž�¢µ¨ô“Ôìªó	5³B¡J ¥‚¢>Ô\²Ó`%¥"~¶°1ÍsðêœŠŠ�€�ïA3�5¯Ö¹M‹5�‹¢´G‰e±Y$ˆ4p"4[]R×;‡:�¸lâN|ZG1ß[«ÀÌ ^‚”á·ATHe–bQc@Y–àvºñRJEõTzº
«V«‰óA�º¬±8ïÕ«[ƒ¯užCß5‰KY£"P!$M Þƒf„ˆ•~[]š^J²Ð÷’t,b¢hšëZªø¶ílY§éÚØ‰²Ï¡ÂW­H@LtøS�†ªD„Ê\”âLX³ˆ�.òŒÚ‹F§Ù²�ËÅ‰Ú¬óâŠ8m@Ô„Zr‘¦�¯)‹“&:Ö„LÕà«Š‡( B
) Lh4:‰Î,ivÒ JI.�*‚"•�` 	þÈâªJ[ÂZrq¢TP&É¡ÓÆjÎ¹€‘³+JÐŽâHT+ŽTÑJ²H¥RC]EL·t¥Î9·ˆÒÀP)NbÅJsÒ@«2s 4
!W]©,jâ ƒY˜�Q¼cY¬š—Ð’s.0…@f¢L`–UY—™ÚŠxQµl(Þ[,y6ÕÃE’`5GBªè°IP¼�5sÎk]ÝêÕyÅ‘…phA„¢dq„sp,(¥Â›3°˜A(:ü;�BB…Àÿþð—4� B€ ˆ‰˜LÄ P 1…b&B@L@<AÒ`¨sÅA`¨¥ZÖjuðp&
UP„�‰š@ ÂÁƒ À!BH¬0³
P€¦ˆ+µäUrªŽª!L„C A:ˆ	D($Ájf•ï¤5ÀÊl’D]„V©â�¨Ä 6xP¡A€@!  A bZ  !& 8A1­«Ðµ-�×É%ç\ìjkå‚Tœ:º:ükF– °Î‹Jç›fƒfN«jï�ó4­ÃßÁ’,øVj)NC×ô>Éùò
ë¤�Š9�KM®×–ùRWv!L¤¸ØÇZÒh¥^Ÿ�`)¹F¿WÈ:ÍqÙªo‹#‡kYMCß8‡7ÔÜDïµ8rØ‚Rú¥zúCÚ\0ÖÜilÇÃÄa‚–ap�÷¥Î«kÐ¸>t©¤¥º§ÃZ’‘è›&.ëóE]�R· À”'×OÇ8??-Ú÷q÷=ðüðèöûMcÈ2ü:(¥u�Ýl»ô0ÿU»	û§ëµïA�•©J8µ¥¾L¯a{è½�àðO@€¶Ì5¼ûìz—¿¡W‡>>Ú2:¼{¿ÕOÎØ}Ñ´){bè@PP^ŠÝ|ësyú«‡/Ó±‡ßß~_}újÄõ¾·Z~„XMÛvcœ^ß5*™2Ü‚ ˜&ß>ß®—Ç»çƒßû…z�R—z<\Y~ú4zw½È ‡€�Zæâ7}<§·L�­IR=cs»OëÃ]òÛ£j‚Q)¶„v×Žu|9Û6¢ìú�>=~=âj¯(”
¾S£�Åâíáÿü�»ŸýbnN{G£b5UÛ¶ý”çqæ®�˜Øðçàà‘šÃñ½Þ=�Ÿ·§f“H©Ðá÷@*°Œ³»ù,üÏOww÷No·Wiùð×gáâíç7Ó×_ÿìõöô.Žï@ªØ<çöÝ·ÍÃ7wéÔYóþø_¾ü«ßÙø³¬ tø.H–Ñú>@^õÍ”á¤æ³4ûÈr9Ãõ(äð-b¹˜ï[É¯uÙ„N�àð}�Œl›ö0Õ·:Û®�T¨—¢Ç/nððóç¯Ï|s³;­_~üòe=ìãöÛ°û»÷u·°ŠßuÎyûîªÏ¿øûëí¥ŸmøHÆ2ëç§Íë‡/ï§ÍáºÐ«èð;0q¬ÓKÞ~ëxÅ�ý³€+ßì>W^>~˜ëíÉI��Ã�AëEÚæÖ¦ççç	»®Šï@P$¯/¥ûïûÿþ‹¯ë©?™+ eø.( V¦¶ïÂ:¦¥l�¸¬Rµ
ËDÙD©Óš5H˜Zž‹í¿s-øpIÍîP‘:�*6/lN7[üì›ñ|ºÙPhZë%Õã»Á‡ûs	Ÿušàðw@ ‰°MæåÂ|Ð^*eø�
¤åú‹øv÷p÷xjÕW˜ÊháÝ×V>~˜Ò¾{ß¥ñî›K<m648|$Ë$M¯8Oo2ZWƒÙpÓ*5OÝîÔåõå±Æ]ï`
?!‹®»÷q;?~ü¸?~öøÅE†÷  Î+¶W§¶<Ü4]ë¥8üH[WÔ«SÜ}ýôéu·ÛÛ‚B¿RÅæ™Íéöó×û�ãÓ~{ê7Ìçûé¼=šl
Šå‘ýÕ·�ï¾ú¨Ç›Î¦"F~¤ðˆþææêõî~
îú0ö6Ü‚T±yºô7ßÆøÕÇO†/zÉ Q†ï‚ƒÇšæp¼‚>ž�özx¯îåñé¥;ú…ŠÔ)ÙþêZ—§û»Ù½ëK® ‡�`­¿=í§ç¯¾Y §í©9è§‡»Òú>^·n}¸»ÿÆÝ]6g”¡ƒ©±äË|ø¬×Ç·�÷±Ùn’f€CR¥Î3»wW;ÿò‹OÏ'û«þjúæñ£¢Ùf+ ‡ƒRšq¾í~©ËËÝ—¡vÇ¥YÅ†w (’ÖOßþ¼L_Ý�Kx¿)(FXÆ±;š9=�¯]ß;˜‚Ã{b¶Â¹©Ìcû(4�*k½äíû½¾>ß•~¿	}st��ó’®]?‘à°bX Ëº8/’eØ€ æ<çrûî¾Z’6“FnAP�&§ï×òôéƒíú]õU)ëÈîv‡×»¯¿9[wGlÇóýºžN{9ü2HÖÑšë««|þðð„o²J…P�8£½ŽÝåáãº«·ot6lA ¶¬>ú*¯ÏÕïû(±á €¥4²oÅæ¦ÖØ^ïëËÛôRvÐC[1^ÞÆÅ¶~íÊøôÌöØ·³drø1(Hœ±oo——·)¶ãõ£³á¤Ji‡Û_ò8ùZým/«Ñ(ÃH]rÀ¾ÇåñáyÞŸ¢+Zeø	( V–¾ÝÚ%-©ö.PÍ†Ï@ºRæUÚý¡[Þž_§ã&ªdø	(@Ù;•¹,AmŽn^Î¯“²oö=4ŸJÜ´�QÄ†[˜ë¥–ýgœþø4n{,4rø3€�Îíßµ›t¾[^º&ì[¶—‡§ó«ñ´ß´q.›]…?bµBû0O­‹¨B,/·×p÷¯çµ†mtEÄ†?0_Äß|ëjóòòó;µÇÛf'wßœåzÓõkV±á» Ä˜ n·õãò
ëœ·Xe¸©kÒþÐ–ååùitW�C±á' @*É]Ë²Ž57Šc³»œÇò¦ë6W>�.£;n\Q(¨3$n‘×ùÍJèüi+¸¼�—7ÝöÔiz}{™Ûm{<îÚòôú¸Ý½+þHÉ)ùc§óÓÃûC§šEløç05ÚX´ûåã»éË¯¿ù„Óöêx­øÙÝKñû}w³Óõîë§‡v{èJ6Èð; ÄÊÅÅö´Ëç—e:uB ¹šmÂ.,ë+s;©NlØ‚"VWøÐ4²–W›@Ï:üH•:]^7·ŸÁ>ÜZSwpÑ*ÃŸƒTÍyd¼¾ùbúúénÂ1n>¿nÆ·»«o·;Vþ1(ÎyÙn®�éy.¹ï[Eþ,ö°Í»æPÇ—OÜ,Ç‹?EJ^Äo"æ<‘Î{E�
au©±Ý ¯óå¼ªW~ ŠÌ˜¶öEt—_<æKŒÇµ­Ã‚"V¤¶³T–	«ªSŠ˜Í+úýnWŸž.oí>v³iIõÍÇÛÝñüòéþ©m7Œ&"u]hŸ½ßÈøz¿\Þ·a1Ð†Š�©Ìa{ºÂúüô¶ºpìƒÒ†(Â‚U››µœÓººþtØèÓùù8nw×>Ÿ/çWºm4MÃ±ºRÝÎì²ÌyÜÄ@þ ©IæÛÍœ—iÖ­GÈ2|1¬iêûS³<OOÜ±k‹ß‚%½…«ëøÎÎ÷�Öï7].
?!´5—rõ¾÷Xîž^RwèK©
þ>(Yma¸Ùúû§—õr:nœ#…Ã¯€"–òN§Sƒóùë²n6Q|qE¬¬³÷‡ëN.ŸžVÇ®÷€Ã�@� Ïõ¬WŸ!ŸïŸ§q÷®ióB~©õ\dü|7¿=?f«7ûã±“ËòðªÛ¾÷ž
¾Ö´zÙî<_¦ñ2MGµ�šïŸkëö!²ª�¹ž%Ýl�žçíuïˆ<ü:¬ä%Fß¢”³_vU=!ÃÁj6„ MÂè¼yç«ãðç H-¯ÂþôÅ‘Ïo÷a·	Y³
�e®]»u#Ì‡Vƒ)9ü?P$[¶Ðmœ.ednûnß—ôvy^æmœ7¯�šf	ñ:v8_¦Ôaß4fTþ(b9Ÿs»{íŸ¿¹<u]ß’�áßÃÈbI,ø­k1Žùµ¯½k¢BXYsu~×mýy=t�«ÞËð‡°š¤¢w!×””ÎWÇá_Ãl­	~{,óËyyÅrå¼8üS�4ÖTª÷‡XpgëZU�•&fIkÛ«åyI¹‰Ò¢2ü>XJòÒFW°¦µñª*nø¬6¯æ·W7¾ÍŸ^×ißo‚jVˆRM.¨ýñúz«ç¯î_,î·™µ.©Æ~ßûõùåÃ%û£oŒâÞƒÐ-•Ül\ëøúª»]ðªP!‡+P¤fK!v”qMKõ�M¢ÆLŠô­¥4_..jK§˜­xôç5Ï�oÌW Q×äBsÜlòôöüpnÚ6¨3
d €H¶è¶;:¿Ž�¯n×¼S¢œ_f°é®bð¯Ï/uÙ_OH÷¯Ó¼nw¡©Rdˆ aL0Õ�ëÃyz›û©�*E‡ÿ

XWÉÔàƒo€¼Žk\¤	ŠXIF	]¡Õ„Ð:U_\c¢EßJ±iE«Ð¶ªêðC™µõ^‘RžBëûÖùi^ˆhèÄ2üH3«å¤Ù�¢<¾¼¾iß7>h¢Ö¤æBëµ¬i‰�WƒBtø3�VÊÚ ç2F{�]Ûû¦®Óë™zÜ�,rZK]Ú6@ª˜ Ã¬äUe£+e’¥õ>*€Ð`¬sJ‡ØŒÓË]ñ½¶Á‘0Q¨†jkYb{êáçû‡¥fõÎAËÛS)®q‘R!ˆÿ	#áL¬•väœ/k	;Í� !:pø{ ŒÂjÉÑ‡ n®“„vÓD—-Ÿ«ùÆy©Bpð[� ed¾Q®ùÒä-Ä+Åh«KMŒ[ÉëbÚé`NŒ:x4!àt»o±¼Ö3[v"È0@Èð Q‰ZæÊ~³•\ŸÞÞæ¾l|¤Bdø ÑD�‚Ô×Z­§]'MVÖZr•FÆ	¦Þi$@ˆ� U¤Ê
ñ]ã$�—µìÂ‚yM	Å9Ï�` T@D`¥óMPQ£“`ZkFò®^ržµµ^�'Œ¬f¨¥	�ÓTG§MÛ¶ÉyZ¬QÑ®¨e£3Q�¨j¨(U¨;	ºŒi	BL–œ`^Õ›®¥RÍI¤:«¹(]hššø|¾D×¶ô¥ä,J_¼‰Ò„R ¤P ‡V«¦žN“[}UUÐJ®¨ €BIˆ€	Õw±ÎKMI%MÌUZ© ¿	#*mð
+è¢�aÁšÐÑ‹‚¥$À …€b a"¢BæHuK5o*AœÑ*¡(�2œ@`ð,©®äE¤^Q´ ˜úVH.¬ŽÎAh•„F3ÇhÆ…¢MèœÙ¢^4À²ši! ê�0¹B	®ˆ%jxªX!AÈð˜JX’Á¹�¶Ö”¡êÕ¬$«>¨¨¡ÔR)�‚dIr55gâ…ÈºzÕN½Ë9‰+ªAéjÉ¥Ä™-"Ã?AÒ²*KKn|ïmaÒGA¥„T ~ŠÁÓ@q*	E5ú‹-imUÕ›§Y5(Ô«°äZÌi¨ÑJâÒŠx/ƒ	D†‚MMT¥’ñZ©�R*eø-ÐDZX4ÅŠ&DÈº¬â`�‚(’Iƒ£¨Â`¤U ¤b€Ã¿a )
Ôš½Æ J.³Âùà‘�ÕÁ9q*F¡�j…Ð2+�w·€pÚUÄ˜b
Ù‰:G3«GOÒ($PiÅBUõP¢ ƒ4[Ny[;6�ŠÕJ4/Z½Xr…ºª ®j�Pƒ7ª-þ?ÞªÏ3BASE      A  xÁA  ƒ°Yãx` þµ,¹aà °!À&À¶1c8šmÈÀkÀJMW.4USÙÂ&6Ö¦2˜Â¨p›²…MXµ¢±k€KÅ­¤!Zc2–BÃT[Ø„…5`¥¦+ÙX*YèÆ*Ü¦Ã­¤!sØØh2sl(«Å²¶­¤!VÙŠ‘µ-œXÅ6…æU¶°	«h[ÛV¢ ¬p›¬Ù@pš*[˜À*k”­a­¢æƒ$rµ�h“˜æÈZ8‰9#'äf°¹¤ÖHQÖLŠ(ÛZRä!”¹ŠZj`%Ð5ÕZå¬LÇÊYk-—ÛC ¬’ÙZI¹f„¶Mš2ÙÄ Ð¡A´es¹ eb k±Õ\[±ÖTÔ„WLXØ
]-Ô9·ª*t!ÈlÁJ …F ¶Ñ¶¹!ð“v#pBPOS      :  xÁÑU@ E1ô(.órgµ!lËÒMþþûóååååëãã~þx{¾þöþ¹G>ýl“½k{Œ¹�qªí^3º7mgÉUÛ³’rË=ŠƒK¸uG\b—;'A:¨Û¡ÕZ‡J2ƒb(Ž”aÓ§±«CC`±Ö™�AÈf`šChÈ€-³¬aÈ˜�=5Ú´�Eb2É€!Ûƒe1C ™�¡ †°¡æ1ÜUk£Ò@£,ÄP€@È
d4«¥&K@2©`˜Õ-dkP-Ø9Æ>î4°˜ÍØ¶vJí<Õ3m�…¹„136ÖØØt¾•Y›,Ë»aöz²–=C�ó±ç&Ë¬Ý�Ms·“1tvÝ’óæÜcËàÞeÉÛ½Ï�ën—»ªIÚ÷_Ÿ5/ÿd_2CNF4      Uã  xÁ]ŠA†á·ºêKÒ�LæÇ€†€ÌÍà¥+˜Á«ƒÛp?nÌ%È¨´ˆCœt:§«Êç	oÀž‰šÒ”ïö‹Ðæ¿myÕ¯o^ÃåË›ùØ?ÒŸï3_{ßáÏ¶Æe3N�-pÑ³µ=[{¢ßÚ.[ãÂeïpÙ—u¸ì.ÛÑ³‘­pá²Ï¸l‰Ë>‘#9ÚÙ2‘M¸qþÁ®ß‘£%r´²Ä�kàð›ñm%—‰p`#9Ï›ïvr["wGB–p@püÅËæîÔ�¹òîbø]¼-Ãå…åf?¯öNL¬þqŒ¡oAûfœ*•íŸK7µ¥)Ã¼¹?1N•v(�jN+—Žqä)Ñ sÎ�¾³i^.‹ÁD;^š*¯ÄP€T4å6ž”Fh‡œ5ÁÞ*V±ŠU¬b«XÅ*V±ŠUì=ÿú¹¦‘TEXT       Îö   xÁÍn‚@ÐïQîÀäÎwA,	‹˜XÃ�©IWD—�]Ô&¾}ÏÁÆaJ`‰óñ0!4¤YÖ6´·}vh<½ekCîç9´ð;W‚.¬	ëó.^e¼¾D­¶ª.(TR~²>ïâUÆëK´¬Uk¥PI,S*©¥W§fUAÉ…JjéÕi©ªD÷™fôq³Êt›OsµÅný3÷ý¸aí;B<æs›{åã©`•)bôÑÝ¾~pI‹Gá—´}ïü“05>CLIP       	           l     W®ZTR

BASE      A  xÁA  ƒ°Yãx` þµ,¹aà °!À&À¶1c8šmÈÀkÀJMW.4USÙÂ&6Ö¦2˜Â¨p›²…MXµ¢±k€KÅ­¤!Zc2–BÃT[Ø„…5`¥¦+ÙX*YèÆ*Ü¦Ã­¤!sØØh2sl(«Å²¶­¤!VÙŠ‘µ-œXÅ6…æU¶°	«h[ÛV¢ ¬p›¬Ù@pš*[˜À*k”­a­¢æƒ$rµ�h“˜æÈZ8‰9#'äf°¹¤ÖHQÖLŠ(ÛZRä!”¹ŠZj`%Ð5ÕZå¬LÇÊYk-—ÛC ¬’ÙZI¹f„¶Mš2ÙÄ Ð¡A´es¹ eb k±Õ\[±ÖTÔ„WLXØ
]-Ô9·ª*t!ÈlÁJ …F ¶Ñ¶¹!ð“v#p  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  F     Eþ®ZTR

SMP4      Aïd  xÁIì¥Û~ä÷·š¯ÝÝ¿­ªS÷øž{®nã ¾¶“L,ÇÎÄØŽP 	ŠˆD $_$&(‚Öˆ	""1`FŒ`Â !!›˜Û�¦NUý»½÷·¿~­õ{yùgÿ¿R½wEÙiLÙÔ›»vÓÞ\¿¹¾þµ7Í›·×ŸûæóO¯¿óÉ§¿úù/}û³oÿÊ�ù{ßþWÿÊ_úüø+ü ~ŒÀ�C‹ÁáÇáÿËß[ð6ìðãàðãðõ?üÍPàß~üÿãOðÿ|õÅö/þüçÿßW¾ú¿ò‹_üÅO¿üúå'_�O_?_æŸ]^ÎýÃ|œã:�)ªÒ~ÿ+ôþ1ÐÙh3HE… @@ŒAp„�T©EU!@C�  @¤!T) ˆB¢@ˆ¢E„d@„"c  28Í Š"j@Cˆ†‚
H£ @
 ) C
…@¡ÈÐŒTBŒ—Â‰¦UD¬*i³1@¢B�
Udˆˆƒ-H>ºœ@@"…ÁAT@H¡‚ €D¤ @!ÊL…G§Í€Šc’]Å)Œc~rZç7pcž.‹Â4ÆYŠ„¿B5-–¾á¢ó’ÅµÞç<¯H–ÎjÂ? �œc¶ÎµµÇ:MS½7žNÃ¿
©yúºÈX¦õyõ¶Ü˜DÃðß�BMS®ínÛ­ãxWUŽÎBÃk¢ºf˜ívƒé¥ïÑ–Þ ?!Y×dŠº=ér9Nbì&z¿à9lïoyüÅÓÇÜÖ¥•Ã(ÓÀ	‡+=~õ4Ø¸ƒ1†ï€B&äÂÄ¬Ëü’]Q:KRÀ¼ÑìÞ¾¿uæŸànÓ¬D!áOAÐ(æÓöúmÍã7ÇÍÕT`øMÂûµØmôcçMéÝ*Ððë Du‰¦Ý\Ms×‘e[80ü>&¥n®f7<]°­÷+DÈð]�"ó3ï?»sçŸýâ	oÞ´9S”>!š'z{md¸YÁF4´ (H—ÓúêÍ·�ß}=µo÷>O¢”ð}¬ñTïßüÒ:¼{ÿ·›V²Ä¼à°{s‘÷çc¬Úâf‡iyz ^í<Õ(%Ô  yNÙï.÷}G×V$Áð—A@ò’LµÝ×fxîËí¦°’Éð÷Aè0ÍÍÎtß<ÏÅ®h
 døu�ºk~ó¦v�ï¿9áþ°]	€á‡ t\çâþ5.¿xøYßÜàÔ Ÿ� b^µyÅ¶ïßóÕÎ˜ì¨þ¢1Y9l‹ü8<üîfoÖçó‹ †ÿD—Ñ^·i<�3we™¬€’‘¥<¸Ó<ô�¨õíÕ¡.—‹/‹¢Ù_ãty¹H½ÛN Ã/ƒ4Èó¨¼Å:÷ÏãÅîÛ¢!CRLÂÅÛWwi9?Óî“Ã:$£”ð(ÄfÛ:Äc¿º¶t4`h@!°æµj®ß�º¥45ˆËÊú“¶{üâ›E®®ª
0|„hší•/ºá¥o]á4üm¢QW¿¹Þ,ïŽ—±j}mTÀpB4O@Û¢¦nJUáV«d¸A“Ñgw÷vµÓ»§ÜŠ˜E2$T (X–“)?m§‡w_~ÃC½‹2 ¤Íñdü§7¾øùãy¾¯ï¯�9Ÿ>öæíõfP#dø¯A¡è‚\m6åOÃèes}ðÓe8åeW]™Ýç—ªÜ&0´ tž'óêÞº�ï_VófÇËb•~B4Í±ô[o–i\ØT–" h¼Œq»3óñXª˜j»«ûçá�ÞT£�†€BÑ8XÛì¼¦n˜Œ«¬ Z�<çÜîüNúg�ÎÉµ6nî_ú¢*¬�†4ˆÌÜìP�æóàm[Ød á‡ D¹dg·¥ù8=Q]½…hh@ˆr–¸Ùûí‡n|6²-¬:hhAˆF®R¼<^Ž3ÛÒ-Âð÷@ :/“=¼†¾ÿ0Ä�»‚‹÷ (:ä	7·¹?½Ÿ�Ýí³¡†„hž€M»«—ahªfë6qšN\+0õ´ž åT5(®‰ë~{åÓã»l÷›
 îA¡pU-ª¦v±»ÌÆÕ?!ªqMåÞúõò<¨J³ß87©_e1 §yÐý·N_ÿ¼¯îöÏ �áŸB�0÷ÃPÜ¼Æåü•ëÛ«ªR�0ü �K¬¯î1/ïÏz]ï�…’á;  º&uÍ+çá±é®ÛÖDg4|B˜crÒÎyîºÓ+–W¾Õq|êe±/ÑÍçÓtÕºvËå4=<™b³-)†j4jÎ§ªüÖ·ðþùËç¹=\ÃÌ¢i@®^_û�ÝiIÛº¶³5þJ–uqíU»ói­vu©ÔPƒætéãîæ†ïNçº,6s‚ˆ†ïƒÁ!¦Û7o«á/ßË~w·X³4ÛãÜ¹¨›�h¸…¢“Æ¦½mÜpî†µ*J“-4|i=íý¯Àÿä]Zìõšß!š—%U7m�~¼àPíD4Ô PtIVnl›Ÿ†~!¤®ªËåyT)¬�V®yöõýí”Ï§3*·Ý6˜òùržqh·×õ4^Æ‹¦R§èºvfûú>ö?ÿN÷{…’ó’lÓnìù²\rQ—F4ü6HŽÇ´Vo];<~ó<èÍíõ�=ÏÃ©KÍœ:£á; @Ó¤ÒìÐÃeDY´0
%3±Øú½YN}W4¥O–¢á�@�¦)¦êÚF�ŸS¬Lkìj@ÃÔ©úäÓÞ?<+óºÈ6€ö/ËîÍ›ÝúþÝ=î¶W¬"î@@bs³)¾ì¾Yñ‰Ù^åÜÏýêŠÒ95¢á¤5IU^_éürÆ®-ŠèŒ†ÿäÈXûƒËì‡%ÊÖzP4ümP y"«ëb�—ãÙ–ué£�†¿BTGŽzØ\ŸÎýûã´Ý¾¾Þô¼ôÅ·
cDCàÒ§ióIÝ?÷ïòr¿½*F’‚¼CÜ}úÉÏñõÏ»n³o÷`hŒsÚ\ß.æÔ=§Á]î7˜º.{·mÜ*"6 ×Lëö…�óü²€…1ÉHøg £ÒùíÆóqL´¾Z
’§qÎ×ßºÞŸ¾xêìÝÕ.2†×`^cvÍ®zŽËœ[©JGg4Ô P²é¢­ÞìÐŸ�(6[)D¬†ßšçLÓ^mm7�à°¿B6}Z}Y76‡ßÊ%Ži·½Y´Z.eu8ÜÎ/Oó48³õ0Åq»k—Óñ±°ûÒ©Xä˜wÛ}½,Ïim]©~¶jP y]¤.o¶Õ0ÏsiQ5¢¡)ž‡Áß¼Þø¯ŸcÚß´&áeê°nÐìê]ÑÍç)³nS™ÌK6~ÓF¦©ë‡BêC�º§ãqß”%¹XÑðß‚‚Õ¶©jè:v4¬ËÝFóÚ¯É••¥7àŠŒj³kãÐŸ/†¶�À„_CN£C¹7ö!/—%šªB‘Œ„7`Z’wu+b7Ec}•Œ;PgMS¹ó‡ÝÇ‹ñ(+‘ðš–ì¥mà—y^#ªÒ:JøUh^¢÷uíªn/€…ËFÂ=(tÄèö7§þØn]K@$T @ó$q³Ý–^»µKMU— s>g­ü¾j�‡õâ³õåj9 nKé¾yéŽð›Ú–á54"ùr»iÁ.ö–R ÈÖ„ÿLóº¸Ývnôå9§hÛŠ&A4–ÍÖ-òÒ?�³­“|
¿
F38W—%ã4‹©\•,DÃ+h^Trå Äó	ºlöv3�ËË
_eKÑp
²N"lª¨yšç„Ê–â-$l@]¨7›bÍÓqŽÞ•ÆG#¡Á˜ÓjWûtº×ØŠ£Š„?sd²uÕý4‰sÖ:�„
DN+PT�Yír\²VÖÙšð×@FFgëÊŽiíºI¥ð¥:k n@B#alÝZÇË¢¦,œ…	¯@"¯¢–meÝÏÇ¸ÖZÂÃ@Âß ©à|½�2ô§¤©1ÕdMøDNiòZTEâÜåÎHUI©FB’Î6e©f˜N¥­ÄYŠ„Šgx³i&—æµKÉ:+U	ŒàsdÞÞ9wžž§quec‘p’iåFKÄËºjQzoi$|•ì£HášÒºy™ÖlêÖ0#-Ê¢®VrÊ]ÔÊï¤®^æa”¦1áDVF³:[¶Þ¬yÈ	Þ”ÆÔYstÛâª¹<<ô‹lÜ•e¥y\æq¦T¯FÂ÷@£d8s�íq†€ó+0"áSYsZ=+¿JÏq8S&h^,]ã«^§<,EaKqþ}™’5‰“^Í¤)3Z”Y L«I¶öÅ˜çÜçµq……‘p%È$ÈeYµÎq\KÚ†‘@U¨d�¾Ü:äùÔ�YÊÊC„BÂßIp5®lL6ýtNÎî[_Æt9ëÊì-Œ@`@d�1ƒÕn»”O—µµMa…†FÂ§Žš£M¦,JhŠ}tÎ¸
bÂ·A%T2²–fëoÇùù±ÇÝm»o\œû.¯^
PZJaÖ……ÝVI.Ó”'Â[0
E›º0K|™l]K"‚Â¶-1Ms·Öê³‘ð)HdjtkQúÒ`ŽÃEŠÚ”FLø7 i’dãÜÛ�i|DÄ¦´†
Ej^2|µáåãzyž’µ¥ñÑ�¡Hø>É¤F�AUk1.Ý%,µ r^t5ö{?ŒS�†¶„±¤’Lf,ín_"÷'E+Îê	]½¹Ú·ùåÒ_²–ûfç§þeŠE³ã‰ÇeÈêç-�R	{PE^MÌ¥—2bèTEÓF¤)w‚ÂC(`Â?�Bj4kU—•�ù<LkáL!†Hø#(rµ´�ç‚9‹·Æ:Ð Þ‚T!%:EeJÍkN«õâÕ�RJB¬•<CËÒ•ŠuZ‡YSe(	¿¥BhÔ%µUÉÅ­š½µž	ÿ!JÑ3J§.GM«õâÄ	’"ÔÕL…oš:uËR¤ÒZq)OX˜Û­Óã<^JWˆfRQ‘ð« "�d3MáacšÕgzµ†™Á�T1Öj)+g‘r§F
Sˆ£(@#¡©¢BÍ‹7uéd\×aRµ•3”Wq°mrÔE³£gUT ^CIaRZï³M¢0cE„a"ƒHževeYÖ}~òÀPZŽu€@h 	ßÿ$ÿ÷ðñÿ„ü1DÊÕ*©TA%¨É5F!N  E…4*P„@*„¨Ì€¢#2U© 
)ÁÁQh@ÉÌÊˆ iÅE…ÊœUH1„!Àà@ª ƒc�5ª)æ”¨PˆqÙÃ8B5Ú¼–T'€ ¢¢�BŠ  Öˆ(’Ë‰b<½"¯Nã,�cÎ*.8¯eE`$8	µ‰ B@EÉ”3²1…³–Ðñ€S«�ðk �\4jkï�–aQSìŒ·çi~I¹d	jŒn6Þ´Õ¼ÌË0J[Ô`X»!nëÝîjŽãù¢¯Ëúºªtêz¢(JÉ9&Çjwq/Çç¥ÚïîÎOÇs§·nw}Sa>�MöÛr;êx§µh¾vëÔÍËµÙšŒ¸LÓbgÅY†DÎ¤ð-5]Ò„RKÀÃÐ€`Nsòlêc<öVsc�«™€fc\qgÌ¦v^Œ†‚@Î¤¬êTFž/yõ¦2ÆØð—@!@!("B2kÖÕ¨­êÂäGñÎø’&üUPˆ¼€¾.ò¼Œ'çlS°P „.®Ü—ÈýË’�)á•4DÔUýÍÆ,ß<~}÷eS¸EÀÐ‚�œÖl«íÖÄtš”`qk‹ãOŸ><�mýúº™ÏïŸ/
³)D-"âZ6‡æe<?äªh*‚^ƒ óhà÷¸=wçqÚú­Ï…á5(ÈL4ÒHuA�!y[Šƒ0M²¹ÞÌ_žW¼.v›·È^ÎÅ®h6£@Àðk $™EËb[Ë:]VUg�Ua¸…Ð%ié£ïûS´ÍÞÕ*– ta®ÊMý€¾ëkçÃç P“ºvÛ=œ?/šæ[wÈþå8nw �RB¢kš·Í§oŠÓù}�»zQèªKÞ^ßu<]å‘L†-(”HØ¢©.ÓØ-kžäæ¦Á—OÏv7êHDÔµØv~€ÛÒk6ÐÐ€ tL«¹9àøòÍvW›D5J	ßÑ5Ni·—NÏ®KbµÐPƒ´Ìã’‹Wo·øùÇ�—ÝëýâÔ - �þvßôÏ—'…ß–É@j�Ä!ë«[·~ópŽõNÍÕUã>ö|¹=”N`ø=¨1š†<nßÜÅ—§cÏíUYš2ü D£Îh^ï^ž*ßî+•Âð�¼L«^¿v—Ï=ÚzÝbÀð‡`pÈ}7·¯÷EwúÅóX^·q5”¬Cro?ÛÏ_|7ðWwXû§/Žhn›l’‚aÐe¦=Üâáùñ…•ßê!?AÁ¼ô¸ú¤~~xø�Òîn2ÑH†„?ƒCŠ}.ï^UÇÓÃƒ¦öÑ¾Ði‰Íõ]9�Gªšö~[÷�ß| ^]­gR)á$§sž7××ããéi®·ûb‚sbñæuýüüáˆØ6W×V?Ÿ.ý®ñV"Àð9ÔÀä4Û«O?)ó—_þÅZ¿Þ—Ól”j,Ë95oJN�¿¸`¿m? Ñ§ØÜob~ü0ôûmiL&Ã	
%›™mYºNëLS�0Öå‚Ý˜øðôM½;Tdø„¨ÎêÌ®ÍyœG-¼§ÍÂðÛP#ŒIåúv›—ã‡#ü¾p‹UJh@ÉÓÒû{Œ§‡cÂÝü0Ô  ÎóŠÝLÓãƒ^mw¹7J†ß‚aÊÑ··7Õ|ù¨7›²4YÀð
J¶³´Å–º,'[[/  öÝR~ëÓÝx~·,Í«½ëH†„
�bîüõý}ž?¤¾nÛ;ºñ§ïgvmÝ…êœìîò±{~ÖvS2dXµç%>mÌ‡ÓÓÛÝf4`¨¡F˜ò,‡Œç÷�Ë\µÆkhø‡  Ž¹®[}èž»jw}5é»Ç³-ÝæÖ®ï–¸½.e%ÀÐ‚€D&i6%.c?®µ·6hxÒ2#ü+ÌéýËq­ê²€1‰Ûnn\w9/¦¬„FÉð]PÄ$~·mÊq¼¬Õ¶¨˜D4ü!Hž×{ßô^N(ve=„¡!šgšÍÆÛužMiéEC
…k8\›ñô2»¢,A¯A!óX°v‘¹¿d­­WI9f¹Þ£~?öíæ�²Xj¨@@4õÓXÞ Ç—O>­K¯ 0Ô  IæY¶-Ž�/�újÛØ¬†€Báš ûýfžºHS–´I~’ãe(ËÃ¶‹ýSµ)[ÀðË „«¨Ù9 /ƒGí�ËÂðG �‰ÂÚ­HÕ¢6¥X¯@¡è’­ow./qÝ—�€Â<:´ûÊ¾Œ3Xz#ÑðP(‘¹ð»—ñ¼¶¦4êEÃ¯ƒBÑ5‹ÛlÝÜ¯�ÖÔµ¸$-(P®šëM]¬—ÓPØº±¢á7A@Ö”æí«¬<û›ÝUSérêªªl­Š€ÀºtvóVãûãSo¾Õ¸H1Ôð¢i@lî®ëçãi²íÎ!	…áû D9+ìæ¾¹Ì§çµ€»kü™çÃ¹Ùl&
Ã·A@"âÚÜl¬ë‡ó­Ù×‚,¯@¡pe*Ê½¤ãð2‹nvVCB”Ïåîu9ÍÚ^55è©j¢ˆñB÷¶ö§wÀÕM�§$ 0¦Hÿêª>><?&×î®_»Ëóã‡n½Ú¶’@aø¢iŒ¶¹®7y:=›b×Z£¡!Ê%MùöÐœqy–ºhEC
Ò"ÚVÕ„å|™«9oö×vìžŸc±©�¥h^h|Ù˜—Œ³0O™ØÜªN/¶ª÷·yÎ�i,…DÃ€ÅºöØÝ9ÌÇÓq©[ØLaø!Ñ¨)ï+'kÿ2·qI¬hø(®9-ûÃáÂáy^*¿±jŒh¨@�rNýzóªÐÇ£ªÖ+54 „S,îÊ<�§‡÷ñj_;ŠÑ°i…5­[tY¤Z*JhA�bMkjnï¦Ø=÷¨ŠÆS ßÌ+X›IÓp™�Aµk›Ë‡çù©©Šz$DÃ÷A�F�¹¾iÍ‡ó¥S»«�Ñð�@¡0ÆaÙ¼ÙÚçïÎ¶¹ªŠ)h¸Š5ç²Ø»æ²^.Àvw0Ûåãé]Z6Ûâ’ò¼ôhï®†þùåÜ6ÛÍ!¢ásP�Ó,¬ª&qFWx#~0Ù©0ÛÒa]4%ÊZP@M�˜Ýõ¡_�Ósv®Üï÷1?t/c]¥¢á Lf4u]Å<tÝ"¥wFÃ¿
4ˆÕá¦¹,—�½”W‡Ûƒ.ÏÝ3Ë»Ca‘Î§~rwWû;ÔããÃ©«÷MíŒBPÀ„¸VÍ~sÑËC‚Û·šðäUŠ�/×á8Ž¶­’ƒ `š(Ms8æ¾;9Z_Lø!(Ð4ÍZíý!?œ^ÎU[_I#ZP�W&_nëç<ËrUÔY�Ñðë  šIŠ¶Yûyì…óZ@Ã?uMR´ûmäzê`‹¶�£høe0-ëâëƒ«¾_–éPïn®6Å2¼LpeUg†ß9Æ¨»Í®ðÓñlLá]òkØ‚X°¦âzã\ß_M£>E—¼Ææp5¿¸<÷¯l±aæ9­®¸ZŠÇóøô"Ûííæ�»ç§óØøm!QÂkP ižmÙ\Û/ÇéŒÖ•ÂJhA]ãj6ûÖé8ž¢§÷êrØƒº¨ú¦lRZ‡”ÈJLp`ž"óîê€óÇã“hë6ƒ�&ì yUkšfbÎý„²¾= çÓKm·ekè“	Ìs]Œ;®óÉ£²%Œ“°…Ö×UdÖÉ¡ª¶7|¹\>Î~-š›fyÇ#”¾öTF%|»kìå¥Gaá¬:	¯@�FU”;[—qíúhl»iÇ¥ï4ÚÚ•ÙD	¿ÕIbSì›v].—ÕVëUã6ã8ž»T °~±FuQ˜íÆFÌçË,UÕø$Þ‚iQ-ý¡l–tîM.Mi,%üg WÒøªb™µB©%%lÀ¼fz»ç9½Œ�M^·{¿µc?wŽÅÆ@$|
T—”µÙ×S×�ã€m]°Hh¡9Ò¢ª�e^ûÅga$ü:ˆ(ëjÝUUÊËù¨¯Í¦ðQ¨Ëº¢¾ºÞÙo.çigê¢’�„Ìirêëæ’R7õKcKc�ÄÜÔ»-úã2Ä¢´ÞB$|Róªpe¹õÝ±Wõu[W&N§Alí¼UC&&ovmÖãÒÏ³¹º.êKÿ4°0¥³„„¿ŽœgqÒºJæ8uSm¶íU²rºÑÓ”j�¥+7<æ¾{™Q¥XHø(¿¥­,ò´Œªíf¿_1/±ÜûÊ'^ƒ)Nt¶ÙX¬ËrÑl�³â 	Hjž‘eç>?õOó]k+ki%kŒÑÚM±¥öO)[»±b³	
(W¤J6û3Æ¹3“ÑºH(@dd3gov;h–]ajÀBÂo�ÅDSzc8§sÎ©ÝÖôòÒ¡A!`(^!ç^jŠhšã¿+wõÔ�ãE�¶…qÙÀH¨@ª®VQ§6IZÒL©¶Uõ�Ç—‹S©ë�C×É¹Bjg	ÿ2ˆ¬+²7»¦�yéG$WíZûržÒ”˜ŠÂ8#á{Ž	Ì¶¨÷u¹ŒOboÂ¿†œ#­Vô&ÇË8g¬8¦Ø'´û¶®§áiÅ¦.}´Y¨¹²”K×1™Ê¶Ö`Øƒ ˆh‡lÍ¾µO]:ÏË¦rž^EJ�P]¨¦nvu�†aP”¨¬À…á BÑ,(j³‹Ò-ë´)ÊÂÁ'Q³¨7æ¸NÝ ðÞ—Œ¨H(A¥F§¦¨	³d¥Ë°ÞšðûPaÖ(ÖùJd�‹2['…1~šóêQ%SN¹ãiDÂï@Aj´³·e«5ŽýŠªlc^–NRÞn·žî¸®+ ¥'&üç UÙ®eQ;æ¾ã\”¥8'j …jŽ^lí’Ña:Ýn¤´‡’ÔÎ‹81á?‚‚¤d;«³ÍÕöi¸	SyK!$8„‚y¢uUUïÖgŒÉ7¶\¼ˆP ”€æh³i
Á¼.ÇÂTMkl·ž†ÁÙæ¦º¼|œ¿:_£¢yÉÆ×ªq>]–Œº,è-„"á¯ƒJŒbQ–E™—”{AáŒHøÇ *Ìi)|iMÖ¡ŸW'Þ—™HøÁ’óêTXÉkæìã¼¥$üK šVAYW[éæ4;Ea|6F� Ž S\œi­·ë:�É%SÁŠH8 xF7y”5`çù²Š­�1 „"¹¹_;›UW1¼ú$@e!£zÔ¾5ÎSëŒ§(E aB0©_CLaÄˆ5.fqµÔÅ%®'.µT4V²@@€ ¨«Y
×Ö«‰Ã0ÌZzSÐƒW_T"kZ§);‡Š„Td ¢Ñ¬¾*ŠÈÜwœK)�qP
 	× ”PÂè’œÙTq�§³Ç¡lÒÒ+jSúl�RÓlÄoŒÍë2%m·mÌñ9.l›MSŒëéqUÝÔcÂ4?‰”åõG3äÜ‹5¥SCUBh þ(š5­…w-Ü:ÇqqtÖxM³”uNi�.)6ÍÁ›9wýº”R+T!`Â·AR™¬H„v#’8Lƒ—ªr®Hˆ°¶)<Ö9Í«-¤€@
™O[S\gëT¼BÂ_…e^ŒÚ�u™«eðÒØsñ¾6nÕ´ˆÉ¤uÎ˜l&ý¯ðAÿ.ð¿ãÏ6«  B¡P‚!!TQ¡@‚	¨EH 	@… EHX��’¡Y5+	¼c¤2«"<$T C!!*  
 €¡€((*ˆ¡j( T!iQ@ A@AÖk„ª)&UZçÅ
¦˜rôT@D HQ¨€ P!@Fö9gc�- eÊi¡JJ4ÖXªP<P(  * H…† †;šVÒš}Ù¨Îó¨«ÖÖãBŠæ´Â¡–ÒG\Rž(…bþ_PTóJƒªlÄóÐiò¦òÖAcžs”Ú—Vò:¥~1uÙz�8¯˜µrÞ8ÃpŠ2J²Öšk™æÇÕÁø2«Ê¤ÔÂïwUì†d¨5¬Òá¤ôÖË²®cuÆYj43\Ùp‘Ëié­­Š";cJP(Ç4bs§Ýøá©(¿]oK1
Š®:ªîª{YŽ_<uÞí< "�¹×«›äŸ}r±Ù³…†ÏA œ¹¬íázî��…ÙîÄØd á_ê0.¬_í·ó×_?�åÕvŸ&5`¨A˜ÔÌÒ¥ìßÜYŽ�Ç¿/ëRŠã8—Ù²ÑÂhTµÒ¦ª«Âç Œ:Çvÿª’‡Ç§¥h›Ò¡,½[ÒÚGS•ôT Ä
j¹o§î¸´(Q&PTgE¾ÞÝ—ÏçáRïK¡0Üƒ c¦n¯-1�^à|éübÁPƒBèª	þÐºôr¹Ð6­šlDÃïƒÍ£EuUsºQM™\Ñ4Î¹¸z¥O§÷}ÚÕÞo»~9»Ò”b“04  š‡s¬o¿Ûœ‡/>”o‘J€áG  I±›®>©ëå«�_õÅ';É$Àð}Âœ.ƒßí�“Ï£Ýo4ü-4Êa®öooÚÓÃÏžq³Ý?2(®Óa·sçéýZW“Q2l@ˆ¦²«¼É—çeá`³04 D¹Ä	››íx<?_W�C6Ðð9Ñ4äµzumôë§¹ØTM!dø§ (X¦“?¼½²�òÅ¿µ9ÔÚeQJø
óù¬Í·n€/ò€7¯ëf¼ñN/}Œ›ºþ2Tµ;›o}û5žñ5LuïÜ£!j�	i·�ÇþØé«ª¬`”-aŽq@s»=ÿ¬{8±†-Ú�Ç2>åÊ”.ªˆ†ÏÁà0Ž‹}ó¦Æ7ï>~créÍ¦jÙOÏ�s…u“�†?i�ÇÜ·H§ááv[_x_ó4?gS5b“0|
…1G¹:¤:žŸ/ô¶Ù¿­Ëáå«Ëj7•õU�~>jÑ¸C³<OšÚf ŸÎëþíý§ÿèÃOÿÿÛg[“ëRûnyt®*à…‚uêÆíwÞä¯Ÿþük|òvWº6cíÆÙîë>	Ã�@óº.¾½E7»Å»�qQ ¡pZ/Õ¾5ÓðxŽ‡û­”- ÷ª«M1wç±»ij»
…á?…¢ë:æ›²9]º§Í�·¹¸z“»÷ïÏ¦8ÔeÃ=Q�Wi¯v»u~<æÂÕ›ûÆï{µó6É�ð?ƒ tZ2·X~ú¡;í·mE(I²4£ç.Žêœhh@@4¦œª×¦ŠÝS½¶RÝî[|8}Õ›Ïv­Q¥0|…ë4qW¦÷O_?Ú«ëfþ 
câT8¥îÔçr_nïî|9ž¦MÕ”ÃH#	ÃZÜíö�ýÃ‡G©LY»¬øª¦·»¶€†ß!šæ%·WöÜ÷'Uˆkï^�óÇ¬»bo+wb7m]—–Âp’§åRnßºØ=?¬ÕfëŠ$`øH^æS}ýKŸ~öþë‡ºÚí9w±½ÙTfuT	ÿ(®y¥¿©J½<.ß^ÝÆôpz_Þ6µo)¦.û²YÅˆ†Š®™e»5Xºn©7•…@ÔDÛ=JûégŸ¼ûêgÇ÷×ua¬Ã[lèÕ0|’ç¥góf7§ãCÄuSÉ

Ó¼¨=T~>½ô¦ôeN¾B”‹ÆM{(ñØ½¬Í¦hh¡¡…¢±C¾º©Š//]t¦¨vûýÊé|Yª¢6É@î@!bÎ¹½YìúÜ‡¶u…\üf{ù8Ÿz˜m«j�†{¢:)ÌÁoÐ�²m·a”†\#M{[Ÿò1ËÎ´Æ d¸i˜ûÚ7›jøéçË¶­MY%]—e¨²�ÝµHKÿ´ìÊ¢œ­ÑÐ€ §››7¶ûÙóÜ4­Wj¨AˆbŽÑíî_ž¿|†¹*V€ uŠ©ØWWS<?Ê¶)7Haø¢˜s'Wwf]_Þ}Ý_íëâ" Ïël7¯ÒÐŸ_àŠJ$høP�s?ØöF3?>­Š¢-£ ¹Ðæ-\YFe[ˆXÑðAˆæyÎöêÆ].��®ÙlªÞ(P QÜuÝËKVÍÕþP/ærœUY"CDC
˜Ìdš¦Îý²ÄäQÒBÃ(®iMöÕëòãééùiÙ\• 0Ü�BÉX'l+ú¾;¦Ñ6µÙJœ×ù8©”7›bXúÇ¨"¾¬…iyŽ‹/c îA�bÖÅo^ß6_=�*Wù6O½ÄÖYÿ„0ÇeÅþ“Ê-Ç�—ÓöÍÆ›Õ28$¨Ån#ã4�É4Þ«aÄ<›í}3—‡_í­DÃ¿
˜$Å¶EšÎ'ƒäX6u9Oýóì}i,Œ†ïƒBÑy:µÕ/m1ž?þBeÓ66ÈC~h´ò»5ÏË2.¹µ½Õð
hšˆúà¤_.ˆ¦õ–680M”f_?ëzAæÖµ¢á„(RZsyµ÷øâôå"ßj�$¢á:œ‡úÍg¯ë�ïÿÅêí�ÏêŒ†hDvfŸ³.ã:íËšÅ~ëzIí­ÎžªíÎc5üÔÀ¨.OåÍý¡8~üæå„ëë«¡nçeZ"Š�X¯@ó´yófÛœþìÃóPíMò0iäÉ–Ò¨§høHž§)?¹ÂÓéëœÍwM1ˆßšÇí«Ûýt|übŒE¹·$!ÊˆlÛ}a§¥_¢©*Kg4|
4/*fSÍNi.ªÒg#ZPÀÈe)·‡ÊõÝpŒ•½©ö‡¾{ër/c§êÜÞ\†¾ŸAs€w§e™2«hî/½»ù´õÃÃ»a®_ojÃ@�Æ„¥½:¨ëºo²³Û"îAA4#ÊrSêË:Ž	›J¬ÑPƒFY¤ªw7ÍÓòp¼Èöÿ/NzeËÒ³ ¿ßêv;"NœîfÞLªu,p¹d¸T€d!ŒÍÀ€fŒ †x
sæK‚ÿy
þ „,Û‰3ó¶§�fw«ù^ž'lÔR4þ3P :ñÉí¾ð<¾{XvÞËl7  #-þê°í×ãñÕØ¶‘¸YŠ‘æª±Ýx~º`·iªPb¢œ–“Ýî�sí]?4m:—5]&Ó_¬‰ÿ—š«½“fy|ÿq¥ïº–|ò¹L­¡1¤Ä{0z¬ù¥uo‡ß¿¼¿ÈöÆÐ2þ¨©–:ƒõóëøzë|×Ô9§sÕÖwÅHü}�Ëä‡ÃWÈÓñiu_ÛÆ˜,ñƒ’±¢l·»ÝÃô´fÙ³Û´íã%Íc€bâ¯@MižÝuð§ùùãËr÷fã|£ñg`É‰.ô½¯e<r1¶§·ñ§ P$ÍÚÞ†óôzqfèQ'±…�‚¼hw³id:�õMO«VâÔTéýU8Î§iœÑù¦#ñç jY*á}™.ã§‹l°Ù¶ê—<žg¥sŽFâQ•©ÔdîB?®/Ÿ×_ù0CÁx5ê&“hoŽß½>”§Zw2˜²æ¥ñ>‰?5±:[c.ËeªÅ˜†B¤šg3Ür÷aþ°ŒkÓwbŠ1Œ²°[–uÎ‰©Nœ˜x*Šj©Ã®\Î/m€®Æ¿šk]ÛþFfŒŸ/¦mÚ6Í &áêLÃ–Zse%7]»\òiU:kœU‰÷ ´–E�Ù©º\ÎU{³mZØ5å¥À9:$þPÈšRÑáª9\>OS€ía #Yhª�5„ÄD-	ÖùÞ£¦)­¶õÖx*Tª3[ãå<-µ:Œ%$v E©šƒ	ÁISö4�Fâ=ˆ
Ísžnö‹¼<=®m:+#¨ÐZ£Á7a¹L9£Š«¨eQcÛ¾»ZóùS�ƒk�3P�‹íº}x|<~*²w­…¡HlAŸM�ï� ÌuÌVM€5D-«TßX¯º¤	¤NEâP5««¾k‹ŒË\çlW¬‹‚*ÕfiÜà\]—uIžÎŠHü¨(U³úúv•Ë9Ï(¾�x©v­¦oZcs×ìÓ1¨€"ñ·AT@UÔÐµ¾3óé¡f‚7Å€HüªZOß;hªe^[q.¨Hü[ @­:Y¸vïöL§‡×¶âÕ	 ñTh-9kðÞ°ÖµLF7ƒ‘œÒ\ëœ±ÆÃH BÁeè»�ÃüzÎØ…Ö‰*dMç·M;­ã«mÐ„`ÅaÒjœm«K,d¹µb`$þu¨P©ÉQºêQô˜Nû>�çe°�³Žb ÿ*”¬ÐšÕ´ý¶;Î——q
¹·íê Dßm�¼æÅKccLtÑ³¬Z;»7a\NÏçjš`Mµ0÷P dÍ«©!tÎæ)é¤´--(B€PŠ–UÐ»½„s^ÎÙ	Ž! q*TP×’}s0Û4¿\f˜Æ§X#ÿ5$4‚ïúeJóÄê�Hü�•Ù$ïš>»)�õ‚ÐzKµ‹¨Zg��ša‹íB+Ó:–Å7›¾–å|³øà¬8c 4 Ä7 ¢‚LZlØnçÄéy<5·mëV”¥$‹Æ:c…"�èA¨–ÕÑ7€�¸&õB "„Q(­ovöñu½ÐWã�…µ@M!–RDB#ÎX¤!TIÖš<ChœY§²jÃ†"¬
#V”;¥"»Dc6¶ói*Ùica«–RÄ¹vSÊºžrqÍ.d”5%4°j ¡P  *k.´¢Ö”VíÕ+ À@„J¨hÕÔHãÔ çºä6´a¶³9ç N�¨0öPQ�5y„†µÖbà`-¤41’"jÕŠiÂ4'ŠÝua-s@¼‡5
P(ÿX©4ÎÛZG»!WY³6ÖÃ
¨€$Œ�–E†Ô,e^s#½±ZWS`¬HC �†›¢S:2u�uU³S+o@‚ªB[QÚÐX]¦µvMÛMë8ôFT(BHlAUBDkFúvÍ8Í£õN"	*”ÐlS¡³¨—ùlP5ûZi‚õE
h*ŒU@
�hIhš®¿¬y\ªí®¸¤u*3é6¶YSrtâi”
Òÿ¥��ºÂi°M“e^ií&¸ÌÑj€ñ€(…B‘øC�TB�!Înš¾Öq³ï«©ÔˆP„ñ-H°h¥kKYè¼mkž•¦“¶:u¥äÃ1 ÿIÿæé?×ÿþoñ'�¬*$ Q�J�€( Š�B¡ˆT%R@Š¨P 
Q¡�† €€�4dô !£
T(  Ê»ø-ÿ÷/O*P¡@P€P¨BP�
RƒˆV-¥¨¨5Îy1R™­–Âè ¬±N\j©¥h¥¨P¬³ÖYB£«ZŠˆBŠ
@€ ET„PA�ñ¤Q�  )„¨!D!J¡jtcœu­Éäd-½3VlñI’)§F() E¡R›jUaÛ`,*SbMaw«˜_ç¥øÆ{'ñ_‚Ðºª²ïv½ÁxÁŒF:Øø/@QÍ(^öÍ�w—××yg›¦Ùµ’ÆË8‹n<=D¨Ù¬Úµ›Î—ó³Ž‚ààŒaü=Ð²B}h‡°¬§i¦í:z£`-¹X‚jÖä„Æ‹ØøsP�Ò ŠÊÊi²»]ÓÉr§jÛM%@­+dÓ÷¾®éT¬Æ©aü@×t–ýMËñ{ya¿éV-]Ó¼ìï‡ððúü26wC°	Æ¿B*×|2í‡Ç�%ûþ¬EÀø¿@ ‰iÙ^[yXŸNcEK¥ã¯@!êe¢¹C:¿>M—ívXe{€ä|Z†ûŸ	¿yxw¶_‹ì¿º9<ÿŸï^°=Ü¶c¥Ä5‚¬—Æü•ÛŒ?}ÿQíÍÁšlÀØ� 8/k{s¿š�ï&¯®9|ÙËôá»÷Ëõõ�³š
¡hb†-ëåôT\èlµÐØ�€ÔuZýþíM}ÿùÃ7»^‹ŒÑ:Ã‡~`¹äÉ5­1�=H].+¯®÷õòþý†«].B0ö`tHë±4_)/G`ÜíOnüë‡o^ðæ¶3*…B]‹3[Ø’.%;/–"7 P*(¸ê€±ŒCçœS
ã=ˆf�Lÿf?½œž>/›]gª‚ 0kíÛ«†ù2-®é*{@)«†7÷Wå/¿ÿ�šíµ;/F)±©ó:ù»¡Nùô©Û�'•Tcê¼ÌöîMï¿y~·Ö‚îðƒíîáÃw¯ÿ¼Ý¶»«7Ýtúü°úí®=/†B½¼ÖðƒíÝñå»§Ëa{#ç¤¨�Ø€€dN·,ÓË‡»08[ Æ_€BÑ<ÓÍ�ò1ÍW¡K¾c‚Fe»›ûCyþöý%ßlûô"F)q
TÑîÛ‰iž•Þ8@H]¦ÅÝ|éñÍëëX‹³×÷[|z|?cÜþö¦ÇÇ�ª»Ãd’†u-Nn-Ê<_@ïœ@7 PŠÔàûÝ’–œÐµÉ
4þ(MéŒÃíÝúøüùý°Û{S0þ
¤!–ô$»šOß;ëWw›d’‚ñ¤H]ÏÛ_¿ûó�ÿïàöªî6�ï?¿¸/‡nw;àáñÝ	·‡�€)<SßJ_ÿß{›ýÖn¾üÁ€ÓŸ/x{Õ}F­B#©¤ºÛŸ�³ôvû£�Ÿ>ýÅyºê®g…Rb
ÁÅ ½RÇuLèl£N4þ>Ñúv§vÌ¯mi:º"Œ[Pˆ$KØ¸¶è±Œ�qVã¿£CÉÇ²y{ÕÊŸ=|Âp¸h”;¢XËÈî——Óç©í†$UÀx‚‚5qøòÍæõñÓˆ¦óíqùöåÙ™FÈØ‚ ¥¬+†~Ñ½¼?åÐïª›D)±pN'·m?xz?³ß*ÔQ%¾ZW5M»]t>/¦kŒ/Âø¨�Ôüêû·_ùògŸžÆíÕV^!¤H]æ“»}‹ùòüyæ¡¿±ûéùã»ïÝÝÕvE‚‚u>×áþ­|üö›¸ºÝ,,
Æ…yy®~dºOŸ¿=7×oÚI¨„€ë¼Èîf÷tyžÄõ[OÎsÉoß\Õãç‡‹±Y”Jmè¹L©ä®ñÅ@ã�u¼,ýý_i¾úõf{#¨ ãj`j)ãÝ�Oxz‡¹?4»¶ñº<~Dhìv·ÎÏ/OµÝn�Ì ã‚ÑaMêvw�O¯^ØµÞdÆ-(¹}†ÛÞîÇéû‹\]ž®FÑØƒ 8.¸j./ŸÐ½Ùy�¿
%ƒ¶•MÂ²ÊÚùP�hüc�u^rw}<¾šÍæªQ£dì FXJÖÍ·ç§�Ÿ“½î%ÀØ�4(cÖáÍ×ýóããSu»6\DÈøPr{÷ÛÃ]÷ÝËãè¾>Ì7£Ñ¸¥6Ó*ía;¯§%»×¾�[P0ûc¾i¯<ž²þx;¾y’¸£CZ/ép}SòÃ÷SÚûÍ	2þ(µ9…z¶xÌŸÓ¦i¹«Œ?Ñ\J	oB~øøé#íÖ 4þ�šæTvwfJž/Hm·º¦žŽãríƒ],4þ¤‘¢SÑ7_Ì—ç‡ï¦ávf©dìA §ÜnO�ÑÝo;¨%(L k·îTÆã*}ëÄŠÆ¤p®{<�ñfßZ“{�–e*ÉÝÝ‡Óó»gúþz2
P¨sÖþz?˜×Çñ”½mï¯ëôÍã¶·›n®ÂœOÒ}}·y}}„Ùu]½@a.j†»›|z÷9áG›a6 0ÞƒÕâº�”uÌU¬7Æjü� D¹.«\˜–���é¾ë$	JÂ„á°KéøzÑKËáËÖ.úþ5µ_íÝ‘rZF»¿ÓÏOÏOºÜm-¨ñ'  äÅš�›QŽóÒJ°*ñKPPu‘Ð¶-ê…§à½ƒ�ÿ„¨.e6ûNËñéåì·»ê/§OzwÝ9Y,4þSP(ÌyuÃaiÖéu­¾ÔR4Þ�EÊêv»7	/ãe?xI�· „5Ï‹¾|³=}úô"Í¦m÷{±åùé]ÅU?ôWþéýñ³Y÷»¶Pã¯@�–Uƒßz¿®ÓR¨›«¯ëñåÊ…,"[P(:/3î¾öúüôÊÍaË©¥èRp½óçóãç’6¡;´.ŸÆçþpÝ&�„PSIlîÞlÎO//·ÍÞY u®3v·/§è¦³¢V4þM%aûõíæôô`Êm=Y
ïA“æµ½ÙLøðé…®Û8ˆU ZW[ëlžÓ˜[o­0 @™Õø¾3ËešSÜMÂÓùå3ÙµÃVùòò¼<¥¦wf€R5_°vþîåqšåpuõƒ&÷í»3ß;°j¼…¢i™ìîÍA_Ÿ^½÷» �a�ÓÙ\¿í›óñóG®Ìh@�w P˜ó%™;àr|:Ïë¡½yÍ/�ÓeÓí`L�?…¢ëººí×·õåñã»dv;o²�=Q�xj‡;ØùünZ›¦o„VÔ¼hè†uÎs‘°o®¬Oã8—`ƒS+±uÕÍaqåùòà[©ÞˆÆƒÕY‰þ¾úï^_ªkºíè(ÿ=(¨™ôÍf5ëºmè­1–j™aš!Íe^V„¦_Cü› @ëb×M×9YÒ%•&xX‰
´ŒuÁîþêt>¿›FÛ_]ïnF>=M¸»nÄeh9Î—p÷¦Õòð´äÃ®K�kY¹Û_ãr|xª¡ÝŠÆ
×tÖýíP.¶Wíª0„(r¾äÍÍU¹\^??7?¸nÛj(7  äÅÈÆyÍ£.íºÝ]-&½žG²o}{P :“~sØûùü4Òu½OÆ€\°æþ°ß®ß×tÓmE‹ˆÆ¨™Æt]RNRï‚eÄì®ºa-§OóU¿é¬Z`’j·]//Ëú\ÑxOHüo á;é/9ÕcfuÃ0”e9>§�íf€eÊÀæÆ§§SÊ«ëï¯{}>>|:m†~HËøë`ÉGÈvÛ@Ïóyc‡²©&þ(P�Ó˜w÷wòòôr¬}ØÛ Æ_‚-óŒzuwKýîå•¸�QJÜ‚Hšm³ß^úqš�†¶õÉÆÿ	
3×µ7v9ÍGt}kÈœ“Ûìm™_¦—/Ü&ØdŒÄŸ‚ÂTêÅmnÞ6ËÓãX›m¿»€€–Ù8sUÂX/ç´ÀO1R5WÚ~³ÛÔ¼¼ÒëÆ5°‰;(“TÓ˜ÄyœS»iÕåõò\¤¬Õ²äÕ\vÛ×åá8ÎM³u5»·Ð’ç`ïk�Ó˜¼uâmü,iY]{3¸ËòôR†Ð‹1–ñ§`Y
]ÓvÔót\Ó^¶áÐÉãåa%¼ÝÐ©@âÏÁšÒ´î¶ÃašÆ�gß½ªHÜ€¬s’¦î;�Ÿ&¡ï;›Åˆj¹¬¶Û_5þýå¸‚u€�u–,mÓïër:VçB+¾XˆÄßEóˆÝþš¸œ^»ë‹�Ä7 ëjéuZ$ec�…Ä_‚¢5×š›íîvu—óóÅ´}Fâd]-]«N¹ˆc­@â@ë
i7aFMóY\p]µ&þÕ5;í†Æëzy,ÆGk€ZW©²±œMvìèŒˆD‚ªkš—þª�Õ×G�¶õM€™µúf¸Ú‡é2ÖPŒ!$zTQÁà·—öe9.3ã<E,Lt (¨eM«6nc–Ë'äV‚5>‹Œ÷`-«Ec;½,`• k h)ÉJ+5¯jp&@âÿ Q™@#› Z—%­è$X8ÀÄßÁÊ¤4fhUNùâ
áMP1¨™”nh•óˆ“ã~pÃXNóÑ6¶ÆTcâ�APk.Èns}S1=>Uo·ƒÔ*V ñ7ÁR’ƒë�Ú•k‚ëi@&*ÂÐ¹'LóÇbì~gÂ’—q\`7ÖƒV(;TMtl¼ó5ŸRNtƒøZ§¥¬llp°‘ø·ARkVXÙµð/ËjmÛH aE$Þ‚,6{„`-1—Ëê»®é€”Ç³•& PLl@*”5Ï–�íMYÏ/¾”ÆµêŒ@$~
iTueiØuöT—×óZa6[ãKžÓ˜†¶õÛçË²®—šƒ	âD`%Þ‚È64�EªµÎZŒ·Ž€ÄkPUªK¥©Í^ìÇùuœŠ�¡+†Ôì
ßˆ¨–Õ{qÆšx
ÁZÖjC³É¾¤—ñlÝ®o®Óš%5AºdX­h‡7”�OËCpÝÎ©Za­5ïz—5¥9™Ö:±�ø‡ 	¢ ðÍ&»ãzœSÛÖŠ5Ô’,ÛZÕ‘KpÆyP'«fØ™.—*®óEœæ¥°é‡]kß�/ó½o{XB¢$s	Òm®^ít~zÕ¯Ú½i»sy^„¶i¯ UÀº–¦„6y<?�ž�oTFâß©¢bÈ$™~ãäËY­i‚+`Y!¾ó=äu}±}íLG�‘¸A­¥Tg[“«¨…±‰{JR3Ä…0�ÇWÛ˜¬…/�øwA² Èbªß„¢eZ™L¤)ˆÄŸCµh	Þ4NQ&º¬â 0n@-¹ˆFP¥q°Ö@$n@Í.5®ó ]¨ÎÐÃ‰_‚¥fgmW|Î“H­N ‰w @¡’ZËôMß58=ŸVo÷»+œçyª ³AP“f�Ïk-Ž¶Wc!"ñÇ Q¡b!*m7x3ž_/Þì�ç%Hg:¨*h`$þPDK.âZåR-¬' Ölè\£’4Ï©iÛ.WŽ³‘ ÞR µ$�Ö…ªk>kk7½‡æIY‚u$ß‚P²VUoƒ-XQáhéÿ¤‚ $Œk|#ËºÔÉÛÀID ñ$«Š±š$ §ÏHÅˆUkŒ!�¸ˆ¢ÖlÅ6M65±'ÎXP‘ø»P-¥ZÄj�i�AEâÏ %³S'½E.3ÄÒz# R¡«º€m×ì²YÆãì¤výÆÊ\j*Öy‘Ø¡
ªj-Åø6´)¥uFÝî¼Ö2eÀ4Æ* ºˆ‘¾mMÎ©®�ñžZfWõÿùüXBASE      2å  xÁA  ƒ°YëñÀ þµ,9©±AM`±•à €�"TG¦â2‘H`äPèÄ…Ì…(H£Œ…± l†ËX.ªµÅÀX•ÍÐ:‚U¥±©¦)c›är‹5�)Q0bÑrn�TlÓ‘ÆÚÔ˜lL‰Åbj˜6r²Í¦,‘ÍI©$™¢9ƒmÃÉ¢fÓpL˜êJlmk¬7‹E¡,RaÎ‘[6+Jˆ¥”² kË¹6™ª€1‡¬In’ÖÖÒÈÓmlXhlLbÂrÉ†¶µ`d¤µf²`+&ËE¤JhƒAÚ„a2±XÌLpÂ¶-˜[”“3
‹1iZ’J5ÈÜjÜ²µF1�Ðé"m.ç6rÃ4�I‘2Šá²,¦� ,çRc0mcåVÄz‡~BPOS      ë  xÁÁqA 1ÃßŽzŠrB|H‹Ð‘þþûóíãããûçyž³÷÷×ó¾öó}ñã¾žgë×õùÜ=ŽlÇ>-—.ï3yS‡J�¼SmÜwi2wR4Rg©-©‘N:j‰�Fµ•H#u¢&G"´Î¸ˆliYŒYéDàÈ‘ÑÂX»ðXŒtŒ0ÌcL€6Z3&³0Ö0¬á`‚f™V3Fd0 2`ÁÐÖd,f¡À�…iD Ù Ða(A6¦,Ö¢SëÐ°ÊL`A´¤XmÐº£¡±ˆ K, 2hYcpZ`€™aMÆÙl0, ÌlÆ†VÙÃŽÍlkªµ6ëá™�¡m;Í¬cÆŒÓ¶øD
/¨CNF4      z  xÁMJÃ`†Ñ'ýrkH#QJÀŸ�·à\Þ�ks/®D‡T4 -Õ´zýz=§¸iA—)°™D 1ÝœðÑÒÇC:]=u¯ó»•ôtø{§’Þ÷ÞUÑÃlÂ÷¶*M5=4Ó�N=�®È�tÂ¢Õ=]~ë4ÅMG¸á†›jÜh†›®y8Ö9Ž©åþLÛääR†„c°æµ™¤]ÜÀÁÈü˜o%¼o©Ó£™*Ü`4``îÃÜÒ£ï?´2|¤†êüÍæ“TQ.¡„fd4³"¯Æ:ùP–UÆ›Õ:Mmý;ü±Œb–×1�¥
(P @�
tË?s>y¡TEXT       Ëò   xÁÍŽ‚0ÐïQî@óõh$aÑBã~$ˆ&³":qit1NâÛÏ9˜Â˜€!L	v‡Óa?!4¥eÖ6•g¶oœVÙÚx8Í¡…­ÌŽ‚.¬	ëû.–2^?BW;_*JUù}Êú¾‹¥Œ×�°¬Éš*JU,ç©ƒR•¥¥¡s¾PÉE©ÊÒÒ°$©è¾ÓŒ>nÎ;nóqö[ìÖ?gÏÆÐ~!ÄC>·¹¥V�Ý çÛ0 �æöóÂ%-…!.iQôQ¬QàÐ94rCLIP       	           ]     H®ZTR

BASE      2å  xÁA  ƒ°YëñÀ þµ,9©±AM`±•à €�"TG¦â2‘H`äPèÄ…Ì…(H£Œ…± l†ËX.ªµÅÀX•ÍÐ:‚U¥±©¦)c›är‹5�)Q0bÑrn�TlÓ‘ÆÚÔ˜lL‰Åbj˜6r²Í¦,‘ÍI©$™¢9ƒmÃÉ¢fÓpL˜êJlmk¬7‹E¡,RaÎ‘[6+Jˆ¥”² kË¹6™ª€1‡¬In’ÖÖÒÈÓmlXhlLbÂrÉ†¶µ`d¤µf²`+&ËE¤JhƒAÚ„a2±XÌLpÂ¶-˜[”“3
‹1iZ’J5ÈÜjÜ²µF1�Ðé"m.ç6rÃ4�I‘2Šá²,¦� ,çRc0mcåVÄz‡~  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  d     cþ®ZTR

SMP4      ^äÀ©  xÁI³eéyžçûy¿µÖnN2Oö™Õ¢
 €Ø Í -Rƒ
É–<ñD3ý#8ö_ÐÜ¡‘á°d:hš$Hˆ2‰,T¡ª²²ª²oNv§Ù{¯õ}ïãëúlÓ•2‹a¶œÏwËVÎ}áàÂÕKý…X¼÷µë_ï.]{÷Ý½w¿ûþâ�òÖïÝxÿÆûòÝ?øíï~÷»ßùWÄþ~é~û�ßý½óßù§ßùÃ?ùÿù÷ô¯ÿ--þ˜õ'¸×ÿü¿ ü[*
üKø_    À¿¾  ð€ÿð÷ú§ÿ[ƒÿóÖïáþé�ëŸýõŸÿÅøó?ÿÁO?üÙßÆÿü¯ÿîòÿýè£/>þñ÷ÿö³ÿö�Ÿ~tûÎgŸÝùåý³úùÙÝ'�ï~ôù/üâA7ÉOxúr½:9=[OëM�²!ñÇþWøOù7ôÿþ'¤Q5J¸%ia«I&¤(�’Té¥–µ¢eÍ$;S.›48�º�Œ¥FÒ©oÔ)jµª3ˆº®à6’5[ÖÚ%DH!PZ–€´�éÌ*E70¨“"Û&­±$(
%X–Ò´œœU}·ð|ê´Ž©6ÓÒR§a Ñ„	KØc·ÖZÍªè†a�»iÚ¬[Ë©¨�>¢ÈN'€d[–Rél9)KÌ¥Î£ge1S×Æ:E+��!Zg;3É@2NeCË1k–²Ý÷ý¦žŸ�­°(ª>I{¹½waœ6¯W›çS_m«‚r3(,Û$(ÁidËa)ÉIÍ²»¬Óƒ5‹½ƒ³­òòäÅ)ÃÁîÖpqoê²Z&kÔ!J‰põÔS„•"0NŒ)š ÙJ ¥ §,¤ÀT.T=?WYlËét}^|:†ÝªäÖ™UÜ¿Úï\ØÉa|ùìéº�/¶nžå°VFé©9‰."¨ÙH `£�r3¯­gÔÝ×ëåå¯5–_~ñóGï\¾v´Wv6�^wÚ_ì géØß®åééÙ}ý�ÕÑùª{öâ°?Ü><zõüá'ítÙ]=z°Xoˆ:ï’ e¶†°ÀØr“œ%jy}>åÎÎ[�÷O_¼<µ_æ×>™gEô®cWfQ_ÏòvùƒŽOî¬~>¿|¸¸õ£e]Q¨JN2·Ð4[Ž§Ë»�¯í\=Ü>i_ž­ÖÛû‡o>Ü~¡M×E‰L#ÒiK  ¥�jŸÇrï�õéË¯PoÄÞä§÷Ÿ30¼s{k¬QUºTD`›&	ã†„”4„±€4¸K ØHÈ4»3¤Ý	¥Á(Á ØÂ�•IÊŠ;1’Béª¦@Ð8›C€ÁÂÂ¤œ $œ¶QJ2&-[H)Ò6 d0Æe nRÕbZ•ãÏ¯ì^¼Àqûjº³Ó¶¾>õÚdÐ»P³9–äVÝõžÆõ�ÝùÕýùÙððã�¸ºûöf3¬G%ƒ•T )#±	0i	%¶e,,'6–#R²çl–ÑNg6³ÝËï,×|µ>}àù72ØŒaº4X¡lv@-œïÕ|ôÆ÷¯Ìo^ZðøW?0¿Ý~çéù°z½ˆº“µyŒi!u&Ýš)žŠV;QŸÍþî×¶®~çBüà¿™;GoÍ.�gíÁW�·–—fªy>ßôC–tÃáZïS_íÖýèÛytöÉµÅð»ÿõ–7Y¢ëUi‰(²Iã¼ËóòäŒ½ë_£®¾xV·¸|åš_ß¾ûÑ�%ý»OçSžwÓB3¢®KfÝÙãýÿ�åïÂ§¿øø?ýàÆö¿ü¿¯ÎV›¥—]Íó“Ë¯½úü{ÿž�_{—O~ömxÿßpqvzÞ•EqŽ^�®.�ã½wþãïëÝ·xüñÏWûËégœ´iK]QVËr¦¢×±”¡[Ÿnýíoí\½:p÷³/òàzþ3ýÉúdÿÇC9Üß^t�¾øˆ+o\ûmò«Û_¾ªC¹ñÆÍƒ'§÷Ÿqôõë×®§ÿøðÑK8¸ye1¬V]7fŸ¢YMXØ„�)#!ÓÒ.ÂµÑ^n:Û¾ö�+<½óùC¸õëï£/oÎeï½ÜÄéQw&23QBŠTXrº‰$p³!NY�7ó¶>4¯w~^Êåo¼±>ùêÑÏúýËï\ªðìqÆé0{÷ï÷ÖµJQ’œUaK–Õd+T’LR‚À‰áÒP#…l;Q"!Û™"¥ g¦)’íLyœµn–+Îþúþå7ûÛ÷?ÉŽáÍKíÉíÇÙuÌ¾ö“ƒ“:™.•$EÐœaÉ6™2’R¤[ÐTd:Cµhê¶X½ÞÿK–×ÞŠ|tçñýƒ�î·4�ó:£ë”““‚”™€’4JÉ4�lƒä)b½O}µw9¿páhâá/·/÷ï>Ÿ–çk¥”L”�¸¤d§-$7˜Y²¤Õ,ì0 °IG t3„’4˜r‚)b³èõbùìÃo}ãúË“Ó»Ÿ,,>øù5×uDé©«Åfs¸™¾ûüáükoÅðÓOžÔ½~ñ?Þo›•é¢s3È$‰pØ‘¢	;g"¹µXo‰W‹_}°ýP¯_ú÷¼[¿ñáM¯£‹1®.¾ÜYúñÙÓ_üÑ•®NŸþã_oÊG7�þîcU)…–­X"[FJÙn Å£†Ó"$52q4»…2Œ,“Ø YJœ	’­”…&‡±-”2ÎpI²9c`ÍÙÓ£ÅÑÛãÞë—wÐXn2sk—´RÈ¦)¬ «“Ú¦‡9çZÝ}oçê%›GÇí£ò�“íµ'§"Ia2ABNd@±œn²ŠP¦@­Ñ†ìVñd¼°m/ë—��ùµ7oÝºp|zï~¢ƒù›—­Ni™„ h4Ë�ƒ4Ø„%%IRÁv³°²�)K²ÈL9JH%JGœÍ!;§I—¢â¬NÂ
 i’¤Hg“Z‘�+MQ;d&Øb³˜�§³'¯fGïÝ«G>Œo^yãæ†{O~Ù�o¿uå[Û¼º{ï“Ò]¼önï>øâ'Óì7zx’ëB„’&DZl–bÏuÛWvr—/ž>®ãÕ·rsÿÉãÛ§ýòÂ yÝÈQ‚l•t¦JO­5e|ôæ|9{çúå³Ç·?�ºy«üøÍÆ1üÃ¿žísöÉÓ'_ÝÝ]^½ØmŸ¶‰"Ù‰Bn™Rgœ¥ ,“)ZP°kZ½²m
‹<?~ÀÖ×ß\rÿÓ_®¶fW/~ï£-M~¶ýÓ³ÿnû�·ÿùÙƒOï·“ùp­|²w¶É®tál)Éi[’Œ›�PàtC8‰�ÂØX$®1ŸÆ¶~ôîòâ7ÀO_}Ù¶¶Ž‡:vtò¨¨;±~øÎŸýNÿÖå+ëã{ÝÿÁÑ…7.¬Ç{O|Q¯.—G,Öm3HDÚDØN‡Èl1oyÜ~teyõ�sV_?ÿëko^ïýäþÃsí^\¼{º{:ª�J5¥°)1mksÜÿõo·úùðÅýÏ..Ìóo®ktU)Â2j$–;-'„“4–Rl+IR!UR²e…m7)$ÛTÙ¬”& 3±à†ÓA Î´28q†NÈ NlB 7œ2Veº!ŠÃI�¨J„iS��m×<×m/÷·T^<}Llõ×~ºs–YId`#c9el‘P€´S8,ÒÈ%®A‹ h4Îp€›SRHÍ4DØ#Y[LÛÉ‹òóW—/|s~úó;Ïæp°ýþÇ«Ú2+R™`$agbBaÜl@£A„”v¶Æ‘RSD£9¡ ¹EË²ÁJ‰,lc)c°dÙiaÙM–ËÆÆ„”Jl¥"C¶33�«Ã�•–‘Á¥HÙ¢)P˜LRB¶ÒX„Ã4R X¥ Ò(A8[Z!»Ù‘V*6v`¥l"K¶-‡qb,Ë	é(�e‘È	’[U7Ë—Ë¿?˜]¼zùúúùW_ü”k;û[ïüâ`�£BE6)p’ pJ�„�ÈÄ‰�±RÆ‚4) Ø!HËÂJ;Zo·õ�Çg[?øÝzóæ°yúñý‰+[ïà{÷ï=Ý}Ìµ÷bx^_<éÆ�a±½»¦‰(Åµe¬ú‡ÓÍÅÅoåãéÑ¯æôï~^ôú|¸s5/¾Í—/?¿|½¼´ÜªŸ?ø²ëf[‹�—ÃØšêÂ(•€IP@’)JÀ’¦.Z™q¶s{Û;W¦wÚ½ã¯âZyûhŸö€ÇƒNåÒb¶~¾û…Ùº²?Ë¯žãÅb¹S¶rXWÉ–2Œ)ei‘"[¬ÌT*BÊl–UŒ §H¶›ƒ”, ä6ÎDÏº|±Ým_½8uüðÙöÕõáõÜì=?yZÇ;Ý<Æ>Ó)D7g˜™6QÈqž8ÛÿÕÕ¶}aÿL§›'¯ÎâõùÞìÊ/¶7µÕÒ(�šíH‰VJNz ºØš]?Ûœ½xÙ¼XŒ¥#9…zOzñðl±)†çÛ/ƒçýÖl«-_òâéQ¿·ý&ûÏONWÇ-JìŸ÷±ž={°=-
;›Ï_¾u6\z¯�÷Ÿ?y<\¾p¸µ³ÏúõÉêióráñÌátÖT××‰/.×ý½ë<xqörœ¼êÝì\ùhÛóåÎõƒ\½>ñóÒw]×úª™t1'Ël¹µ·?­_�Ÿ¯»í½Çë×g/ÌWm÷ ˜ÙËÇ€wŽVŸÏOïÞ?¨»{ïÖ³áõËÕ“Ùf¶ì‚I®n¥”³ƒ/Õ½£7·Øæññ™â|¾XÒÜ¥«R*àÌ”À	9m"2IY"`¬§bqx¸ýüµ?­¾°w´½¥þùñæÙÆ»Û—æÛÙékj}ÙZÍ'WR*¢âVxìÔ•±<ÞLóËï.ÙªÎb¶^v‹€Î!¹Oíx�‹åÖÑ…åúÕy}ÙÕ�­·¹øôìä	­×"ºˆ‚±madcK–ÒiB
š�    7”c�î®v÷w–+âÕ=:–ÝÖ@ÿºØÅ�T)ëþ‹ëmqi¡ÍäW¯ÞÝßYÎæôMNgÊŠRËê¼/Ãîî¥‘ÓÍëX­4�Á¥eÈJCtSw¼¢_^üÚbÜ>}q÷þI,Ë3!‚T“Õiìï¯êlo÷0^ÎOž}–‹ùþÞ›‹ÍÖÉÙz3§ú®:l3ß[–§³Õó—'Pv÷n=ïûñåq-›¾ïcCNË%Ê´…Eì”’¾®g÷g¥ßßÝ~±»Z=›6CÆ0Ó||²·ê—;—.´éåt’³�­^c¬Ÿmy¾éú~œ¿>;a³ˆ™†rÖU§lIÙü¢”\ö<¾^3áÙLU~¼•ó�¹÷ÚTWÖ5»¥Ÿ p“’ÛN	6­’ýrªOW'cÏÎÎuYOÏŸ>ÏNÃÉIJ2¶ À€2Ò"l'’Ò	]V?:œÛ;³+êú|uVNOû®ïÃ�†Q1vbG
YØÂ²U'ˆn«ßÝ�ó“³1^õ[ËÙÅÕêõIÅó­­Ë;ãj}¾q¿�nè˜%8A¸mjÅ³Ù|Þ±~5½nçýrï°vëiU«Ót1d	¤-ËÂ€”Ø)ák·2ŸÏ‡6åéZcH}§©‹Ù¬t›vRÏ_Çr¹XN¬Wçg9Îf\Ú­'Óx�(Ý (EÆ),Ò�ÅÈÎ”!9q„±mAÆ™²v‹ÓnCÎæóùœi³vsê{)JH`+XNŒ’vŒ]?†²®›ÓÓó§é¾úÖÉR¥„R€§Üx­ë¶KÖëÓãÍë²³µÚj|•SX}ÐD(äLˆæ$9m;œ›41æQÇqí1;fÃ¬Ï–ãšu´.¢­3»~9OmuÒÖ#³ak–ø¼­š¡.º>Ô;% ,¬Ä‰”jrF8HgÊ,X�BJÒJ…!-ËnòºkYQYv‹Æ¸Zk’bpOdŸ§  [¥±À&%GŠÄ–!€L[vAÈÍ	Š"ÛÕ©+ÒN¬Ò™†"£6’´26 …‹eLbÀaìÈÈ°N�q’      ¤$ÀN	C‚$¹1•�W“Û|XÆþz=�ž¼8±¢¥¢g”LPgË `äÄH	™   ¤7Yj‰Y×SL]×œº~¾ÈæcmªJ•.:HYu:lJW–ž¹w—u5%îfsfÙ6m­Œ”»)"JQÐì´ëÈº(vbÞ�s½ÎsÓJ”AQŠXÍ!ØØ&d‘I¶Üh]²+ónhéºÉ•Ã½“èU"xª¹Ž–¥�Eth]§:EhéOÉTÝHEôDØØˆÀNBa’ J Ù2)[)Â¢AJ cX¦eË¬Y“~ÞõLãtîˆÒÍ¢Ð9WLÊÎê"‚"	” T""šÜ�…Õ$° Á j©Ž¾ïJ)%Ûj=µ(Ý¬'<Œ9VFÕè»Ø„• 8!‹l $F!+I@¶!Û`d’’œ4	‘™–$ÛˆÀÎ4¡bšV¦�é©l3÷D�FÝÔ6EQt]‚ lœ²#%°”  Ô¬5k)ýÐ»§ÈmL¯»ÉŽ.¢Y²” €›Ò™5Ó=³®oÃ”­mb£©f¥²ÆiµDÃàDÎ¬ �œ6 Hl%!‘-Q„2�c)È–µ¸«ä”9yª©nY„(¨ÕzžÑh¥ï¢ƒ”	¥ŒÀ‘ÐD(¨¹ŽJWf„i%zÕº&4›™hk6;õ1kÝèÑ“£ÖlP¢ Y&	a\CR#-EG«®Eaj�ápB£@¸�Üœ!	X�duJÍÎÒ½EUrSYË™5'iÆ¼£s‰€Í´6uhôˆl”e×Ëºl›q]¥TW:u&ˆÎIŽjSmU¥,-4oxee×¨“‹£Zœ-ëä–h]jm"šWl�c J¡âpˆ4¶"”¤›IsZD)})A8ëTkF·l=�‘»Vi(U":©µš-›•%º®ëÍ›7›¶ViÅ•ÒéˆâcÓk(%
¡ödªe·6Ñ•µlY,H   Œ1™n¤ \2"""¬Ì±4—A*®nnmŒ*ŠQ‹Rz<Q£D?2…%œ›h*=2eèP�Z£ÎÉÕE_"²VçHNQ¢¤Sê(é–ÕJÔ¥ˆ:Õ–iªkk„:9I7™IÉ²l·È���8KàF†¢¤³Ad¢Œ¬®…¢ ­R†¦:‘îºÒ×³£W87‘Zx>•ZÆ¨™-kÚ�í–
êÔj£ôÝ ADtA�²6²ËNÊ±s–j¸Ú-T mãp@šÄ’°œ"-Œ%LZ �Dà–™*ØcßÔ•°Uú^ju,–Z�¦’r�ÆR†>Ý°èëùX*ur’]UËèºé4i©+=®iz—œ6r7S§µ"{ÂÓ-zuR!“)$”RbËCÚMHrmŽACód)ºÎnmEDØ®Øt¨ÈÙFÕêt‰èTÒ4…  Ã(Ø2™J"„©rX42Iìp�R‰�>ÜF²©�hcºÑ•!ÉÌŒTk9uQJQJ?¸„GMmªåT‰68:dj8„œ)E¸¹!BÊ´@jØ²¤-P83Mh†€f;‚œj¶(}×Eéz:»Õ69©žZkQJG"9íF¹É“H"Óá â¦âP“D±Òi6²²eUÑgI'A¤[ËI™5-"�e©Èö¤Tta×Öª¢²Eß–k¨ÃuÕ�½CjY�Šú
I"  À R$   &Œm2Æi!H¥$Ò8‘šÒŽVˆ®”‚È–­bp£RúÒÉ-a`H²M™–Üru&[šŽÎTÒéjGHÙ&"J‘�¡©KjÍt€'l©&+JËiêºò¦Yó¾LL5Ku³v–2Ú¦–è»¾eK«t�™	   €”ìL‰0n’‘q‚åH,L
)ìfˆÛ&eá�ÀÍ	*ˆlM¨3Í–$·4)“”Àv³j­¦{õŽ6vêûpÛLêº®‹)í¥“Ü2�[Zt&�È�ÓJà&Ñd[�ì„”  	l„i¶TŠÝlG§vK‡ŠÝ2E˜f ”®+ÂNE’6J·)S™.%Â®r!”™ P*m¹ØÊLK�Ý�™Ø!ÔŒšÂDF
G³EG¶	ÔE�*Í*³ìj«µ!¹M8zE™¢(m’û®Ï¨SíjÇ<£ÕÑ(r«­¢ÒËX…0dFrš†D gM&«e�’´šŒPÈµ5k W­­i6HÔ±f¥tÙÆŽR¤ê)%l[!ekVDg{Â¸›ä´]6OÅ}vdô‰²Ù"’±k1ôÍ¯§nk÷Ukÿýîï‘¥„³�3›,á4‰ÓÆR  ¨‹N’›Œ�[Ž¦šÒ	gºs±’Ò$2 VŠÄX–H‘éÄ™m"Õ÷¥•Þ‘mœrÓ¢À–¡Ì†Yu\9kß÷=]ä4MuS¦èç³ž2åªe¦Ê2‚Ôf\O”~6ËÙèõfjÙO�z÷
dÙ`0¬°ÃÈ`+åd£:5•Ùs�±ZŸ¯kIº®›�’”8í1¦–5fýlp?¶Õ	c–,Cl­KŠ”¤,V£ÆÈ`ÒÈX–ÁÛ¤„1J�m�±‡PRœÚt‹Åþµ£aõìËÙìêâàè4^¼ørv·/<z¹zqÿ9,–ìeI'Ž°mR 8Ã¥±HÑ„…dË™M‘Që±ôÃö¬«|uþìÅ¢ôK­B™*(í” ld‰0ž(îÆ\¿ó­]bosr|}¿ß?œŸesGI²É!§”È© "…-Ë€�dPâ&	ã´ °%Ùµd)9��«û7·»g§Ö¯b~uo½8Å­CjYSQ‚æi^:Ÿ•�ÃÑ{S‰ãûŸpÆâ�ó,ã¦kÑË¤]%Æx2ëúÃËëÙ‹WÏŽaÜ¾¼y¶XM™ê¤ª‚À© )[(MF‡­†­$,$)´Zj,ÚÙü‹Ù´{ù`î¯î}ø¡.,¾At§FÑõé6Î[çî|ygôîÅ_§Ož=yu�ƒîƒO—-W[©R”­… Ë ´¬ÈH2  ²M¸IÓBÝÙðø¬lÝ¼°³˜žüj3¯³÷>œÕºéKÝšH, cÉ˜    RA4+s¦3¯ï–åµ­g_>üôÑ¥èúßúÁÎ¸—u Tq¶RaH«I*–‰CÈn`…!AáqãRùrûG—ç‡—ÆÕù“{Çû‡µÿàÃË«©¦J‰ÌL	œÅjVó¢­Où¯¿±sãú!Ç_ýxš½ÏµƒÛ{gg1¬·Ì(yà¼ž=k;ööN~õä÷¹råÆ›×þÙñÃOnßý‡‡Ãw?=¨«*º‚[C*Æ-Ò–ÛàzÞ}¼5\z;9{ô¬vûÃõ±\­f¥nMÊ–9ArÖ¨[-Î‡»%v™??~üñú"×ÞüöÞpüèóãgºo¸¿içË°"€d)N@„ÀÙê[äÙõ¤<ºýµËß¾¡çÝY}öŸ/Þÿ¶xüÙOc ,¿ù——^nZÉŽB%1Ø”Ò¤d Ù²Á¤– Ø„,e2Rf¦È¤åT”¶! œ–��Üd…‚º^žÏ¼Ú»ö�ƒ»¬¿¼÷ËÕN)¿ñá…qÚl·ÖÅèÕ,Ï/®Ë“[ó�å»{ýÃwïwËé�þÉþÉ*‡õ°•Õ©ÀR‚‘-§²ŒVHSã¢×‹åã‡o}ó2wN>»WÈ£ÿp%Ï×{ëq;�N H!Y&eÀ¶h‚�•ØÂ(#Q¢RHJÜPJ”j‘‘Àiµ#'i N…lÒ  háP�T¥DqØ¤± aË&0	¶ ÀÂ�–¥”eY–l”r,ÂaÛ‰QXØi Æ`&±	‡ÁI"+L:QBiRÊ°À�² –‘ §lÂ–I°la°@á±”©Û®«óî¾»ÿÖîîg·Õt­½û‹+y¾Þ;Ï>*U¶aÓ„Î$‰e  ÈÈ’(MJ)!%N#GJé°H c ,RÀ&d‘N!¬tˆ´Z[LídñãËËÝüŒû>êv†òÉÎª�ídë¬ts  œN(‘ŠÛÔe�×<Ùúè·ûo�g<~†wº·^E™Î·Þj�€l¥Œ±�­L�NŒ¦!'’ m#"!e“Çý‰ãþû¿ÕßØÛæË‡>¥,?x^�ÏåYc=Ä¸×¦ãáûßn\íó—w±•×·?ø|g\�Ë˜¶™™J 0 HLClæ}œÔég¿{ðþÅþó³�r£ôÿýz‹ñüp5Í[f5"@"×ó¶ÚýøæŸ}gùÎ[Û<ºýQpùÝ÷–××gãíõ_í]|ã»‹½ñç·õÿüÅÕ+o¾ñÇ/Ž?¿ÿôÆöÖÖ×~µsºjËQƒ2WÛ“ç¹æù«ùîf_ßo—²ÿ‡ûÓôbçõÓ[Góèž?¼GPÞz¶µ©5Ú`TIi[¤,‰bÚf>åŒi£ÏßÜºtå`ÍÃ‡ýÖîÑ.lN|çìñ�½{óú…¸Í�×ü”á­[´ó¯î¼œôíko¿{È—ùùs~>ëæ;WâÁ³»ÇŸ�Ýû¿Ø9›ÜJá°e5"§-ùÁÁþöü�k;§�nr¬Ëo¿ñ5¶^�¾xÎõƒ·fWç|ùÅ“Õ¿µýîuòñ§Ÿ>ÕÎ7®íîÃ£�žî½wýæ{»ëç_Þyút¸µ}ó‘<®zµ¡Ê“-DL¦”.û|g:?$¿ów‡WnÌ8¾wÿÂò`þÁ34žluµ+PmI�"ÁÂJa)9ŒÒ`	™” °     cY8lµH!0¶ƒhR�yÛ”¯//�6§óGw?>Ï7/_½u°8É»×Çæ·^½XœmJ±û)�As‚¤@òÔºó­ðë­OØ?z�vçñmf[_¿òöÑêéç�??¯³Ù»¯öWc]´iÖ”ëã.«uÿ³[ÃÑá|º}üÕÎáœåÍ³íÍ”óÖŠl7ÉÈ8ÀÂ ìPÔ^wš_îü›\ýu
O¾|Áµ×~óâÑW_>üä³¯®^Ø>z¼ÜŒ^´ÖU»¡Vnm³­Íñì¯~³\?Ü{þé“{Ÿç»;ßú/ï}~~Ê�þ‡­‹;<ßÜ¿=.sçèréÛù²Ñ›lÙT4È0J ”5XïhõøÖùÝù­½‹;O¾øÅƒÅ“KË¯ÿr÷lSªÐ°C�#c[œ
£TY`š°P¤± d M3MóA«r|ûý�££x0Ýû¤½îf×®hq¶Z�©€°„ÆÓlá³ù£×ïï\¾8¬ã‹Íë‡ç{‡ËÏ–r=½ð£­<¸Ô-WëO�º¸z°wë—Û/ë¢ŒÛ›ÒÔšÂYp6±ÙM½Øÿû7¶/ŒŸ<~pz¾}�òqÙóÉ[ß.}óâ0Þ»÷Õ•éÖÎÖ[ÿp4æ™âûÔÝòøø«Ÿ?Ê…îëÏ�/lt¼w÷É÷¶ol/�§;/s¾¿7û�¿Ü�ÕúüÂ_þŽ¾u‘g/>ÿìtgçÝo]m~püésç³7V^½äþ‹£ýÝù—/¾<{uñòÁµåþâìéÝ;¯žooÝ8q¬§�õl€zº>mójÒ¿·wkq­}ôÅ��åëË;¿ö—¯J7íÔ¬ãât×ëãþÿýýr£;œ^|öàxàíÝ«g³n“C(¹ÚY/†ú|þ7ß/^êÆ»÷V'ýùáöµ/«u‘Ø6ØH&¬©”¬KVgÝ��oÜ îÞ;çMnö{ãzzt2]ï..ŽžuŒ—ÎÓ´XÍ{¿Üût9^
NWw?ûåÝÝ�ÅÍÛ‹qrGªKƒŒ¦™Ò]Éõøl§;š�lºã/žqÖ]zxõòÑ‹W‡‹ùý4)£Èn¨ÎÎ¡N¼>Þ�_zkG�^<9?ïË�Ý.²5)#ÒNa'Æ ’[*=ó*ŸÞÜ¹±»¨z|‡i/n}pi«Þ¿»b1{÷Í£A¯ïÝ~’Wo]ýà'·�T±³¥[÷<cÚìýí·ÛÑååÉø³û½¤±}ãÌ®›yKœ €-RIJ  `d‡­4Ê +66i#$g’�ja   l	pZ 6‚0Ø(-RÊÀÈ$ÙJ0Åžæ®CN~õâæòÊ×Þ¤Þ}ùìÉb˜m³§}mR2«ea!%nV€Ò)‡&[F+3ÎvÐ/·_—ÙëãÙâ(†Å2û:ÎHu6 `„šHìÀÈ	 €I……mƒeÀ€°1 v¤TBJ Ø�LZ)É"S)¶,,£$q„=Íi1Œ›öt/¶.¾ß)žÞ?»íâµ‹Ãêôøþ/__Þ¹tù`wzrüìÕÝ‹çýV7;‹H¢”ÌÉA_Çö’n±}óÅáëÏ qpÈÖ³Ù«—'zÍb»ë°­,v¸¡Öek'ëU¿³w�³“³—#±˜ë�Ÿ\hç#¾Õí.Ï9¾{^–ó­2{\²¹¶›ì†š
€pŽ‹É=ëòdÜÚ9|gž¯^=yu¾Ñl9lVùü|¯]+O¶7Ç ›õýCÍ†Cr’2¤„%[¶RÆ€[i`a¥��°“KJ'’�	&Á	çÔµRrª÷wØÚ™¯×g§/^jv>ôóØ!hîìöÿg=–®yz—÷ÿyßw­‘Cä¸sç®=ÔÐ5uÛeänËÆm3IdÉpÄ¡O8æ#ð8q‚8 		YœX#›Á�qw«p®*wÛ»†®=fî"##bÅZïóÜ7×ÕŸŸ�ÍÉéýå¸?¼=d–6Û%CDd  "‚ @P4JÖÜ½>ß¦=˜ëÑÉáõóþâd³©/ZKB  ‰DsÖMõÍ8ìž3Nî=ªw<½}}ùÅÛéä´n¿¬Ö%%’DQ*‘E @ è’iÓ±½<Öò`ûîåé›óçíxQgïgæ«çýå«ýöD§oJ�Fz¥eõó“±½wöîÕí«çû_�½ïÜïýÍùÛËg£±›N¼¬
A€IÛ™èu^í¶÷Æ}.ß¼�o/»G'»ó«ËË‹ñåÛëÍfÞsx¹=žžÝ}÷ø ]¾ø8»Ó³ûß7o/Þ–®jÚ6ÚÚDsb1¸XSÛ;»÷±¿:˜1ÕV»X€(ã@!†•F¯)Û;»÷Ÿl�ç7GÖ©m§ò  ‚ŒA¥�P… C @€ "‘#  ƒ$ˆ�¥¬   $)JaJQ0!�´ˆ$F!ˆ#’"²J Â  $ÐR¤+™b_ZNîœÔã·‡ËßÐnÝÙ}ØvÇýÅ›oÔæ¥F]Z[vÛ{“®�×ÇuUÚ¢“5¨(!×=Y–í<­ëåõ%‡[›³wž¾ó¦¿½yu9�©-ÕÚ ˆX ¡P Id	)‰Br¢ˆ   #,BI3å
8J�ŒB€Ä  
2J”hH‰$GŽ  B$�(EºÎµß-'óvYo.¯¾àp:ß½óäñÍ¸Ú_ôÖÜfÍ-„PQL �¬€�uz½tºl|ì×——¯^çfw÷ìl¼=\¿ñ4rúe}ÚÌ»;¬}ýæ°UµÓ2R‘ Á…1ô¶ÖeZ¶ó¨ß\�ƒb“¥Y2dˆ th×Xæ¥q<\_~uì§Ëév�úÍÅþJ7§§gÜ[s}\1™X4m×¤’‚E – "
#¨(FD••�H™qYnÙlNÚœÑû7Þy®…Mp…„ È@H$KQ_ö¸yÚ´]¦úÍzÐ<ßšvÙëºßŒÑ¬EÓ²¶ 	Pb¨²X   ˆd€D‘2Áf¹™ºvÛ–ãºßßøOš³ÓL’ $%‘+"a’‘%âºúZm3-sƒãaOW2µ…I- ”RI’¨l.ZZ–eY¤Æz}yýâ‚ešNúL'"Ä (ŽP”Èaì+Y¦Ý)Ó`=×Cöm¸æYµô(& D!Qz5Ö0-Ó––ô›5v§ÚÔ& D1”  ÈR KŠ,F�• DB
	€%äôôÕImæiFÃ×7Ý
iÕ¦6	 @!�$r*Q<j­c¢Ôim/cìßrs<.š–Ì­&QN‡¬Ù,Û]iï}­›ŒF›—ª
‰DR.P�P
CEÅ¤\	$ ¸,#™�Â
  €(„¤pÀpJH	a”%”  (Š�‘AÄ
�!+Y‚Á:êÐ4·ÝÔPú8î9jmªÖZ«ÂD.Y�†2J�’ CN	 ,!‡‚àˆ àT¤$¸‚1ÁEÊe¥\V"  D` H	bdB1¹’ DrÊ‘ˆ("%½¯)×|’6©2­ºäØé#ƒ šçy3·iÍáºUæÌ”ªT­œŒªÇ>¶Ñ«-sÍ×µ»4ÏM‹G?Úåy«6|ì7Õ'�tºT;vj¨e¬ûÞ;vgmª©šRÛy‰}¿÷†¶¥Š6{ÆÚÖIÕZ+TE<Žm%ÕæÚf™4�ãºÞTÓ2O*{mFWÔTEKA„!®*!N×Z¶Ú´©yÊ¬Œõ0Ö¶j¤4�¹„„"•$B"!A�XŠˆ @¤,H‰c'ÝÝV-Ó¬jê}µ3EÓŽ¹Ü}È1éH¥’”"%D’¤PÒq…‘xšÛŒÆ¸ÉÍt¨«\ÓÔZ¥Ü%!²„Œ’J…1Ö1hÓ<µ¹M›‘•›6P›¦9Óšô©J„*‰±@±‚‚   ‘  A!†@%!¡”(‰R!8
É  ! K…ÄAÅYÛpjªjSÛŠeXÇ± wešZs+ªÉýÐ9N5m³±|C]EVUUÙñðH1ešÚTmš}]ÃB´¨D‚@$ aw’6-LmŽð:Ž¸G@¥‰"£ 0]8Y�j£I*Õ$zÖ1FjZ4áµ�•
c¤7µI%e@T�#ÉÊˆRQ†=J5µ©š@CC«Ždmj”¨¶a£‰x¥Ç}£«Õ<’Œ4	uFRR«6µ©4¶ÇèY@
BBI   J°¤(™@1�(+AŒ�(NhmššZ©ˆ�Ý¶#D	.Á@ �£Ñ\J"	%Q    @�I  €¤ˆL@eìˆ*œÉˆ‘�¨µ‚šçrÖ#£¦©uª–jë¸± 5ÜíTS‹”ˆ DŽ,U`(B$3BSÛ¤”><BÆèÃQ•0Ö‰4ÕÔZkEF�ÃŽTMÄöÀjIUCZ›«õZÖê£4UƒA¢¢„D(J‚I@Ž‡»«Ms[VWÓ4Æ8bRUÂ&%%�T«FÝ´%3îÃ.•Ý»¥,$•Bp‰�!…(!Š˜�%Áv¦Z2	S­âuôNLâJE¤$¡ŒÈ	±�¢`pEJDa<ªRÉ #À1R™ŽS•0TS«fY-¶-)ÔâÖrl«G<2
©$Š…Y‰°,AR@¢!        YdYDE0C
˜áŒJK£ªfµ&3FÒ½º¤`ªP%)Ø‘�<z’ªJFªMÒj›Ií8úX¦Më£¯Òyí¶ã”„˜³u‘ÑÇ`ˆ12p‘fE‚2‰EJ(XMÃQÃ}´6ÍØYµZš¬Q¦’ƒ�€(e €!€2†¢Âp *öZi¤�Amæ8} E­Ùkº{‰Q„²"	“ $
XØ8hRƒžÎTôc<±ÉB¹÷$�ØQ2VPHr’¤	`(T�V’ˆY´jM‰%ÁÚ-L"ÃÃ”¦¡8C¢*Ê0nmn“Ý{Ô¦*û8�˜J@%�¢QrºRª²�¤T
ƒ‘†
3"Id0$$ÐQ&Ã&4UX—TMŠ‡«µiä¦©-©c÷Ôæ�Õ{¯L–»{Õ¢)GŽbšæ¡Žª*£Û•ò*Ñ3Fi^+$‰’&4°)†¢î84U+’@“IT§‡A•¤á@«0 )dT”2Y (Q, Èea   (X     J‘’q-RÙ1¡"€A/Uk�”‘¸ÍÓñzß˜ÿËü7,ÿú¿ÎËÔ_{»›ý¸M42RT%$DpE$î�‰¦Äª¹2Á:õdí}$ÉD¥Š0”H"¢8P”åTP°\A&ÈÈ—‘�aŒ¥( â ,PBL",”
$²dH@�‰ˆHð ¯ÎÍ<Ú­Íæñ�u®�ß™´™Ï¾¨R¯Â«{÷Ðn™ºöûã‘Ì©yÚ]r	9$D"W�›¥aS†Ï6ëf:»ÿà©ŽÛóg\÷åÉé­ûO?¬qíõúà=›Z¶u(aER`Ä>ê`e·™NïôãÕþxžmÕ¶6û4+    ITA˜˜DI)$ 1 xÐ[ZãØ¦›ÛýòÎOÎ�›'?xtõ¢}òù«íÝ�nß½÷-^<Xûýe&æv›uîÇés¯Û[gïÕ‹·ç_�_ëxrro³Vú(ÍÃN)€¬(ŠBEÄÀŠ"F*“ñš11_ÜþÑÃþøÉÃ{Ï>ýü“ówœ½ù½gß½~T�n_¼þâ×û»»;·o½+úzù¼^îçÍƒ¯fw†&Ã$!®@bP¢ ä`�"0‰‰Ñ„ÒGŸÒ'ÏNN§‡]í·ûÏ?Ý>ìÓÙñzÎa®¡Ù²­DTAœ†Ê�(�¤¢(‚ 8J‘,+%­šÖ›û77WôWo}çñŽß\þñ3NžýáÙ¤óýéa½}H?’©q½ù‹;g·ÞýÖîú³O~þÓí“Ó�^ÍÛõjSýÔxEÌ R+Ë„$#,™Çý;_>Ü­¿üÎõ÷ùKøãô'ðÎ¿ûŸð_ýð«ñùËåõúw¹Ã~}þël×Ýöño03—·ÿåîý‡OÞ½ºùäÕÅ—üÇ¿ø÷¸øä³çßö£§›Óë_?ÿ³Ës}ãÞûgáòÕ—ç¿ÈòÍ³oÝ×‡7ŸŸ?é�·ðOÏ¼ç¸i³Æ±ÚzÛ‡Ë“Ÿ=]žþ¥ìû¯_Î¼ýö/\­«j£‰õj·yûhÜ|vö¿üá­o|ïôêâãŸqý³Ûÿùÿw:·ÛîøÛëßîž?ùÚ{÷Î?ùñËwßŸ¾~~½Yj¼8ý‡÷O¿ö7>äË¿øY‡[ÿÙ�þ#Ÿ|öçŸ�_=™tò�ONúžZOÇ4<:”¤¥Ïm?ÆgßÔ“¯/¾|õêzûöÎÃwuzÕÛá*;„�!�l}Ã«‹»‡ßª[úêÕ‘çç‡ÿéÈþæÅ—/Ûý³ùéî†ÁÜÞì>>üÎÝï<à«ŸüâÀ�¿ù‡üÁÉ<Þ¾üâùëë{§ïo^z>“MÍOöi¿¶’«<�"bK£�”Ä�!  ‘
�ÉÀ•BH’¢t˜Úáôöúêpñ�ÿÆÃ?|—�~ôSøåG}ðÏ¾þÉÍÅ“«›{G<œ¤ÔÄ8n]3{þâƒåÎ½–ãÛg¯|ûôÖGÏnN‡–¡ÎP qRmªÜô[/ßÑñ³Óÿí“ßùðé×ÿóŸü‹ç�?:û:ñj¿l^Ö�)D)iwÇ~Âþj÷§ëäý§sÿñ§Ÿ]¼ÿþü�ã˜nö»0[(
$&Pe¯ÒLÞÞþåÓùáGû½_|¹nn–o>Ûöq\*iŒ�B„EˆŽº–ùrë'ÜzÊ�ý³ÏºÎÖ;ïþ«WÇ±=L“œA"’fB&ƒˆ
’‚$@
      �(Äq©ÃnÉÕüúÙw=øàÎõÕ¯žÝ)=üÁ/?Û³»¾wœÒÇ@”$2D!¬  ¢è£r¸Óúçÿç¿²üÎž|õë_ÿèê§·¿¾=yu3ÏÇ65Û£�4„‰rŠÈD…˜ªÃRÇé´]\mÿ×¿vç›_{øý‹ŸþŸ¿:ûÞÝÿÿ{Ô×·é»:ºƒ(K™¹bb‘V¡÷ù0nõ‹þÉtë[_ã«ËŸýP·»ÿÁ�Ÿ,W—÷.—�3V\­,E"AF1	¨Ä– P–†D€Å
J  �T CŒ)ìO?•îîÚã‹ýùÍr¬»\OtSjŒX‘€ªpuw½zØùäáÿñÝ“o|¨“ÿÙÇ7·Œ¿õi›_íwóaÙ®¶{J5ëñìõn©Ïî~üÉï½÷äƒÛŸ}õÏÏyøý?ø'r3î^ifàHI¬ju½�®mòéí�ø7ßûËðñÿõÃÿŽw¿ñôoþÃ÷ÏßÔã‹vš®ï_ö{y{þèpï÷îqüõ�8ÿ“¾û{_??¾ÙÖ“£†;.E$²ŠCDHD ED‘“è«¼…g|üæß~úþY~ù³�/rëÞ·W>_×ÓýfãŒN$ p…r% AÉÄ +h+
Á’¢È" �€+B!ŽÂ
@�!"‚$à"DA$`¥1†ª„dAEäŒÂ’•©ëèÓ‹éÁþåÛùðôwÿ->ùÉŸü�<þ½»ÿŸ~ÿ«ýë7>î«[8¤B2¨©S­ÜÛ_<ïàö>ü—|üã?åé7–¿ýÎWÛåØfu¢!<"S�dLÈ(ID¢T*�!%RâÈ’�“(FŠ–•
Š0(ÆX  WTÖA*$«Ä‘UAC‰)ÈIdU¢%$Q¡8X€† a""Ha!É¢ Gr%B‰   ŠD’D•(AbŒÑÚ¬×H=¼w5~õÕ§ýÉãùô½_�í×ãv¸D €JJ@%œ$ªˆaŠê³zvãærùÿ`÷þ÷nÿì7_}ùÝ³[ßüÕàrÌ}§iÄ�‰( ´ê‘×Û‡õrú£¿½ûàáxûó_]|õÍû|ûXw_¯L‡6—×T?iýí½_±Ü¹ƒyûJº»™\ìçÔZã7,wï³œ\|ùÛýÃÝôþ''‡q3«µÆðPŠ  KÓèè°]üºÎöwï}û�»Ÿüü|Ü»sû;×Êq?Wß†×‰ c$Êd …
8r�Œ­PBV”Bà‹40¶R¤�Ò1mšòúôÏžèñ´eyýúòd>Ù¼ÿÓ;ûÑ­j‰M¤Ö*7‡û¯§‡_\|ú§<ýëýeþŸö¾ûýïý•Þúü+¿ÚN»¥OcÄR)Œ P, ˆæÃv¼}Bÿìô½ûþ7~÷ƒ?úàõ?çø/Þ;ûÞ¿:�w0KÏÀ  ©TB )ÃP¥uªã|÷ðzœÿD?|Àå¿ùù¯_òõ¯Ýûküøõ'ëz«Û± I@Jp¢¨¢WÁQL,Q.K± 	
%’8 €Å@Ê
Ä 	ˆ ä€%BR %-Qb	A … W DA@¹"b „(R¢`’ ¨‚N€B!h` ‚dâ(.@CÄR¢YUý¤­×ó_<XnŸ}XŸ¿|ùò¢=æÑ×V¿þe_™ÏÞûÚ>_½>¿º»œ.¦–¬¸Q’§ªt˜ÛÍÉâ/ýè5Oþ�'Ÿ\þü“Ã‡�¿ûåÉÅôÝ`ôUšûq¼<ÑÉƒ÷øüõëç5®úÙýåÃËgo¾Ì§ÏŸÞ{´~íí³·¯�›œžÞc»g­;À#‘ €       ‰P¤¬U½-Üðe¿söàñ¸sòìõ‹ÃòÁƒÇ›»·^}†·‡ÛO®î^Ì/^j~xëÑé¿¹zñéÕÝí|²ÓAq¯V>nÝ·ãx|ûÛÇóí~¿øôÏßð“o=üÚw>š?{ùö«/~ûúäö;ïÇoÞ^¾ñÌi=~¶Ç±¾Ìt÷öNo^¾xusýä£‡_ûö	ç¯?Ó8²Ôïÿãßyû²¾øÙwÞÝ>8¼øü×ŸÞ¿õèƒìê³gÏ/ôz§ûïÞâ“›‹×ƒeÙL·÷�^Öl2‚â�ˆãm.·?ü¨ÿÝÝÕôùŸ¿¼¾}ÿäÉ3voÔÔè†”…‰¬PEÙ«XÒÇÕùÉæÎ�zrvýæu?_6íäôy#CRs�*…Š,É‰ªMc\ï®nss~ü¿¯¦½¯õç?»>?¹ÿý÷mÛáôüí§ƒ¹é^²—'¿=Íé»œÌ¿þüËW¿øôé­“'_ìŽ‡VëI¯Œ‰"Ž@X8"A!qJB&C 2 !d"´òqËÍ½_œýïWíkOÞ|óü7?|rÿöÙƒiõX·Ç-S<<T $RÀ²‚¢(1‚fâP‘â 
V   °„€£D �2r
¬ D)+
ÉÁB•`Œ"¬ˆÈ	4Ç*W’P(1T±.oÜÚÉ2ëU?80-š˜ 0¦(Å+´Ù?;éw¼k™®¿|;Î6»ÝvîGŒ$Ì@THB"WY1TúxÝi·n_Ý\_Ð—¹îÑÊ¥ÄX	P€bP%$”ˆb‚‹TÀ…ˆ‚£(ŠŒ¢J4#$“J  )+@ ä²äT K’IG¢À!
$[©rƒ¥  �! DI€$¥— ÁaÒ 	4¢$Léãr­y{º¼{Í›ýËó¢][Ë€+‚# ˆ„ ¹\£””"*É ‘”È¬ÈŠ\¢ÀV1*0q$°Œ,)„DA¢Œ#YÊ@‘À  G$A©»‹æÑ¿:ôvë¶ž>Þ__¿Y§-»¹mDÀ )+!B)È&®HD	$( ’   @”rP™t‘
q‚‘B"R°°”ÈA‰–�+@b•+�@"dYQSeÄ¡JÉH!™Ë‰®ÓižËº:Þ\NK�v!Œb‚BŒ¡RDÆE�(‘I �(±Ü‚âPëæê Ãn{ëÞýÎÕÍùgýÍ›iÚÕæ0‚¥–$F(NT�$nä°ùÍ£›Û»Ç;ö®®ö/Ÿ_°Yæ»“*† L&VJ"N‚P0²0VEIR)'J”(&!*„�…”È‘,)Ä  ¸‚‚EÆ"RH
&DDÁ@)K”¬‚E…2H
ä@‚HŠ P¯H°¾­ÃØÜÝ¾wëËÃÅÛ·W·™7ó²õÉM0…DlG�¸Á6R‰d�ªà8%  `¢HI¢HÁ�Rˆ	’ÅÀ€¨ q )à(€, !‘ ˆ�á H€I „‚H*
¤R&6ÐBH �rY!D8�*ˆÄrE$     …•Ræðö0únw6�w7ýpysØ¼:,ZZ«¶””	EXA¶ PÌ@ „((Å" €DTHˆH*INFŠ´�‚ˆ� $…"'ˆbƒéÓ~´ywîõ››ý+öÍó¬¢p
ìÃ±¯Ë­ùÎý+_®:LÓéf3†¯Ý3¹(Šš*©d�@SÅ6’0•‹vk^jÐ×qÝ£¬Öš—i§ÍAÇÑ»É*˜ÚÔ`(R#ƒA )�¸”€dz‰R[  Tà¡BQ¤2& ’@r‰R<â$YÓÑ<·¦¾^ù’IÛÍ4µJr=®:¢æ†œ6Íóä“±	ëº_«©5rìémÞÞZïs8÷+VjnµÔ6sÉ„$Ä’€�BŒS*Ll©H9xdxD´6ÍsMž8ôÕ£\¥&ZÑ`(Aˆ$DG›6ÛÝnS{nÆ¾Ò®©I]5ßª-íàãzLÈgš[5bGà(€ÁrE˜ Pì^½_y>™« �qss8(¦-šÅìˆ€ $²*SFE
€K$Áà ªlIILBA©(¡«�¾Ÿ�Ó2�,*'ë¸ê}d²–1÷iÝîK$Áª�‰E*! 
 ¤;Qt%MÂ#Q«¢�DšLF\ŒR2N
dG‘ RR2 Å`(Šƒ�8#NÍËìåè›‘!$ªæ*²Ç:�’&4¹GÈñµh®Éx]ÝµvÝ½÷š7óì©RéûtŽ}pl¦µ6µyÙ,iÖagSÉ°Ô¦Ö$Hâ4Ê2CR†"¬ $B„8)�5„U…âÑ*ô$T1v”9XTÀ²Pp2¼®©Q'l{õImncÝ3ó’‘Z	ì‘‚É©Q„ˆ$r%ÊÎ€($S-)hÕ[R<pµ6M-ÐÇ‘ôŒ14•J”4„QH¢€’¤"L�+Vˆ°2¸�°	 ‚BV%D¤ðÀUBŽP%2€B’ˆˆÈ    @€€"b•"’&”D$   é’¥�Qk­M¨22ÆÇ%Õ¦¶H)	,âT¤$*	IÅ"D”$PÂ2¨âîn¨(nsM)‡	USÍjpèv2ÆpÔ¦ÖPQ‹°%e«È`áZ›Jq4§5÷5gŒµj`Såø¸¤U“ºhKcÊ¸±ºAÒ¼imLjó®ÏýÆ'kµyKëôA…‡‰j
µkÕÇ±Å7}µ©•¢¢™B	.Al«U�A«îI¡dŒŒd ³§©6­5Ô÷G<QŒ#]5·‰1š6¢õ:Îª9>jt)WE  . !  ""ˆIŠÈ@†¸‚H„+bØq+I65×\±×1ÜS–ã ©ª¦©µÄ#Ð¢Þúq†j«IrB ¤$¶«Ò† dbTÛPL†"Pˆ� "À*eÔRa@Š*’‚8D…bCq„KÁÂ ®(å²¢�TP+’ 1HÄkŒ4™A%¦�1F5jÐ«MK��™!!U’P©­¦Æ8ä0¥UóX“¶ô²c1F7š�Cíf”~ìŠŒ±¦'´ª*Çô¥VSµ©-,Cãè¬“¥‘u2‹ça�¡©š’a)d �H áˆšÌ°UR©¤  daPA’œÎ(ÕLÂ Cª•ÔÝI«Ö&UÉc¬ôÊš1GŠ�j"#!-‘Š‚"’BB ’�¨& DA!V   "È  @Pˆ	Q¤�#¡ŒŒàR3^AjŠí¨UÍŠÒ©iŒ#RMŒ>RsUè 
‡R”�S$‘[¢bŠ#µÅŒ›A43��Ã 	Ò» IRXÕp†"‰8     ‡¦F:#SZ2Æ€ªØ+U­µIdˆ‰iª±ŽµÒûè©šJW**Á‰ÀITeEhb¢µæ¾Fm#úÍÚzk‹Èèƒªªž>Mî£WkÓ”–¦"cŒá´I�u¬&�4${DÕë M»LCÔDÒE2z`÷ÐJÔTØ&DzhŒá´ÖššÔ5MMÇ+S«±®•V�uŽ¤B!�4UÒ™¦mš�$Skê±ƒÇX	¢
™�hˆ@ YJä Ñ‚["%+BŠc©-½z;Vjž&y¬£S“*c%šZ£»'jU©Q® Ø )ñpTÓ‚Žã0×éLÆ•iËTµÖqS>zÈUh¸«µY¨×X�eB«‡§šf9]¢Uœ¨Ôð@Ì÷Õ™jS¢¡^åš4´°Œžã¬šæ� )ÃÃªFÆM5Wé�^ËÔsPê�ÿ'þÀ¨¥ÛÕ*=¦56ÕfªIQjŠGº2»G@A‘…ijs•¢$�µ¹Çùÿ‚“_Í³û,àÏó=ç7¼ã�ï­¹ªçnwì¸ã`Ç	(‘ˆ‚Ä°CÊ‰!„Ø±b…¬+ÈþÆI"%qœØi·ÝcuuÍu«êŽï{ßùwÎù>|>’ A,„†±vr)�%•¬�„»ëX� <'ß¸ d!Ä	ÁMF—ä \E‰nå€@I ÉiÜ½ä\’'Z¯jÌ‘6‹õ'ªúƒ
;žR·JùlâÑÚ0ìd�E9  !A Á�ê,e‡õªšæy³Y§ÁÚ* h”T@ ÈKX¿=ïÊz±XÏRÍ^× C$$ ‹9A˜$ÉI p0:à¢DT@™£LÚšA/îvËÅb®KY¯_:ºœ!³¸@3ÑÝA:&Ý*Ä­Þ­³ý2�­^–^]o/`k­§»>Ý»s1˜N¿ÒþÎîûoö±:;;íz£Áî*ÕÝ¦A®]   È	‚„�=HÑózºR¯¿}´;[]L»þ>¶w3Âp~Ñ=Ûj«v¬
Š`!®�åƒ½Aì].Ža8h¶¯}s0[°{øýêh˜°~õ:c¶®ºU�"SUh€(Àœ�   $ƒè™(È� 9¨®²+Ÿµ_Þˆ£¹ž¿~9-ýØçËñ<¯GCå(p�eÂ¦�Gn8Yì4onŸ?º|NbÐ»1(¶ñl¡BÉ›†M^¶_]‹ã[‡�NN¿ºb<œ|¸}ãÉëg?gØ	ß™aÓºùë;áÚû1¾îž®¦ƒòÃ?ØíWžužyðþdÞŸä ¨:gw‰&�‚€Q*ÎÊ8=øÅ?8Âðµž`{½7f©7ã¦1À³ŠÌÔU–Úˆ³Ñãþ;»û7óüøÁìƒ»í÷þt¼Êó-¹+’ˆ „ BÈ Á€Åœ$ ¸ 
0‘r‡ƒ"à€Hà (S‘3†j‰å…ÕGoÝñx1io†7§›z‘(«JB7Lœ÷½ƒÝíçÇ�Ûé�ãïáú`öüÑ“'¸¹Ûþúÿx#¬Ê(§>èîNB Q&@(ä Œ,‚à‡DUœnÑºpÚ´½ñíõ|zú¤?Ù4÷¾h\ë
Œ†â	€9ÝœÝœ‚ J ),tB‚;é ip©   %€rÂ       rà9`ñì I˜§n0µyŽé‹7wÞßÃéÇ_žÌzõ;ÿñ_´ÿ°É¿øø“W8ý¯øO?ÿøâÓ_üÕþÁ‹Ý·ßì§Î·¯ú(Y) 8á€.Â„Bt£¢ÉÑOwÞ]ž¼ºüÅìí§­¥ÎÀ ÊE8‰ ïZuC+£ÏQ_ÿhÐ<{öÓ—8ènÝ}»z´~:Áá^ýŸöÆg—iø?ÿvýöía~tÿ„{»Õoül4ß�Uª_¾|gxýÝêõ“gÏç£ñµ÷>Þ[u›q.‘E§	t¸N`‚€@!Ý ól\o3_T?›_;x÷àõó‡/Îï¾U}ðzÒŸäP'Äà¾iófì¼<øñê£ÓÉË—SŒÃ÷þ¬ÞZù‹Ã¿lF‡°G�'ýÃö—.ýé¢ŽÉ+÷”‹¤b3äæ¼÷£ßln}kœž?¿ÿæ.¾û`´)‹6JUvw  %'X•Òõ–mí—v2yïðÚÍnòõƒÏÓßûïÿ¼üðôüG/ñGxò÷nßwß|þÿwç�×nâäÕƒe|Óþæ�w4_÷*W•P(N#7ºz�Öëå×oï^¿]¯&þRÿçßþçwø†N>ÿùküñwâ¯½sóâñéçÎ?ùÝ?ø½z'¼Ü<øÄ>x»ú?¬Ë¦6àÉív¼‹xz1=.ãúî+«–^™²¹7H{øFoÿ[õ¯.¯ÊÛ³úû[¨.¾zpr†úé¿ÜÍÇ'¯îŸîïÙöÝÏv/Ü¿�ïÝk×g�Ofeçü£¶ªžŸ~ŽgþëûÛß<úúQþñg¿Ñrq5ÿú©¿è?þÖ__=û™}{»þÞg½T<Ó&'‡ÍAÿåÕ«ÇOçÚí?O|5*¤£¨Š‹uüâ�öàL¯N^œÌš/þîv~;~öõO?}ïðú/zíÊcVn·GÛõ¬~ú²ÎwÊ¯n/ÏŸ>ÿÓ¿ˆþûƒ;ýûóo.úrëû?¹�n¹]Ò  ¹klÍÕEÞÈè.�×çíßzúÛÛn‹éã—¡ÿQù•³—/ž6wßÞU]eO�ÞÆöÞÝ„ËÓ“q?½û*�Öå´÷©÷·¿=”=>�Ü;¬ïâ';“T[áä¢×^ßÌë«Wg»;ÍíÑÃbû«�þáÞÊé“nöÞ,'UJlV9y§x]˜¾|Ïâ/=øÍq½:vö�ûx«YöV+ÄÛ¤„jƒ~ž×WOßÛºöF8¾x~i³sçÇ×Ô­{òwÂÝÁxöøÑ'áì_ÿþ˜õOâ‹ÇËÕ^Ú~óç×³åéá_´×¯xüüÕœ7êïœ­Ú%B(6?fï ÷z›ãÇ{ÜoÞøØBªB}5|<ÛÝ¹u§Y¾|u¾¿ªî­—ƒå’!W²d–š^Zaö`w·ÂôôQ½ÚÇ­É_ítÆE;ÿâ[[×÷ççùù×iòOþË?¾‰ayöhv9¼1xŸÔ›d1Õ§W÷vŽnÄ¾y¸™ý³ßÿW»>úòO&ø¥­ð[uX~þõ«Ñ/fÍ¥²ù¬_u=/* eÉEÒ¬¬{y³åþê½ÿu·½s/U�Ÿ^Öã›á‡O¶óºk¢<°¸  D: é…ê¶d'÷þè»íÝêàùå³OëÑðýzÝŸ‘%à+ãÝU�ž4­ªÃíeã‚+§C B�HåtƒC dN:Ep@	 á”XŒTÎ!«WÖóöÏ~µûözþ‹G›^¹Ýÿîã­¥¯Ú	y†Œt D€.—`DV6 �r�žêh«Õâ³ïïÞÚ]=|òåÃ?¼À—ÿhoô£ÙÃO¾|Šë£÷¾5Ï/¿zðì~sí£wn4?øêÁ#U÷¶ªŸ[Ý•ÉÑóUÕ»©[gúæãRí¾q˜|úÓá/¿}ç�núðÁñ»×Þ¸]‡õ«éáeÝ~b	‹^€Çä($ ”($ IfET7*š|òVµ»½<ÿâôûão\ï_¾8;Ön7oþd{™6�FeBN
D'A‰r€‚ÓM  ˆALm“—Õ«õÑèú�öêõ .½{—ÛË.÷Ö-!ÑA	AF¹«€$
‘z�/ÃC«öš«³“Ë‹Ó­Q8**7\    �œ$ ‡S0ïvR9¾÷ß~³}ç{7uúÅOëðîÍë¿ò×^Îšj9¦{vAArR¹.¾.';½­á›y|~œ>K‡·y{túôÙÅv»Ûûà³íMÚlu¥Šg
!˜:³4*å|ûGßm®wëLÇŸO‘4~ãÓëëÒKViS!õËzÕûÙ�æÚ‡õìóWÓ®¾Ý_{¸½Þ À�@! €DP€ w"ÕQí_uaÿ�7Ç/Ý¶vªw>_è�‹�A)`µßéÕÛÿûÛñn?.Ïžß?®ß¨Ú^-ë,_�îWÛ;cl–/Ö³;õ['‹º“­†'�ßîäQÏžçQ¿Ý?èú0,ÆÏ—u{}pÇ—Ç×núGÏ{fœŒ¾>}gxýíþ|ùü|~lÍ»¯z_>Ëv��_Ÿ=²Ëqut´Ø_k^Ï¿¾×Þè÷º''gOpcP}ç~Û]~>ÚÛºî½Ë|òàóWƒöæ`~´±%›ýZ¸ñ+£êë×_.¶öÂ;6Ùî0]½øAïíÚ^Oúî7÷~ÞÛ¬k–JV“ÉD
 (I !„—ÌØ¦Ùà‹ëÕøÚvØðÑ_o°ýÖ›w®çéWOÏ»[oÝî}ôE+ïºþãË8Øÿö³ç?4þÖï^ßmO?þz:ïìWÿpg“fýåóP¼Ÿ——g?{qpãú�Ý¼üæÁ©×~ðÙÎWýòå»ÕþÝr2=?¿¨w“ôÿÞÅ|’?¹×;@³'Ç>¼vûæ‡{˜ž=½¸Z�¶ûKÇ&EU
%;bU¦{?Ë¶÷^h×Ož\n{7Þ¼5Ð¤<;Y�·z÷ÃõÁ(w  ˆ  @€È!€� ^Íƒ‡‹Áp¯tòº\î4ý{ç»òUmÞÁxxíl<›çe[ÙpQD¸Éœ”ÀB
„Èµ¸Š/Jo5Íòb†¸ˆ½21Ð\NšAB�ˆf(É=2LŸ”êàÆQ8ï^]”‹Í{]•ÝA î$D8r:@á’B…(•k³™¡·½ug6<½¸xnÞÜê—×—çO/v{Ûáà“Þ2‰,1K‚  €@7'  ÐII€@	 å@®¡MõBy0>ÚëO¦ÓÎÖlFŽ*;)ÐÍA—A”C%¢$£ÚÞ;Ì'ç›ÑýÓqÞd~õ&w�:ž_ž=ìº¦ß/«ˆ®a± Â%"D   ÈI”$,& sCWí]˜®Ç<¸Q]Vó³¯/u¯jAEDðâbâd¹ß6«­éòòjøz{[ËRe§å)‘›êB¨Æ£½­e7;G©YoŸX( “C"Ae°°öu{¢Íh°Õ¿:[¼¸ê[u÷ÅÁúr÷ã£0ÞYÝ:¯NÎ/¢†ÍhµŠ*™ Á%w²rä’¬¶ÍÚ¾‚½ëîøùýµÕ¨·�»`¡‚<KEÀE÷Uï‘ØÛy§™MfëÞbS3™2)pÐ@"EgÍ•&§»ñð]­×“ãçUªªªL+åMuœGÃ[ÕžÍ¯/Íb}]£å$Þ¿c[‡¾Òë×'O¿ápÿ^?Ï/Vš^Ý¼])SÁ‰â"-8RÍˆõàeU7w7•_ž=_ŒÛ6ôö^ö×ÓÃ_|T�¶ÇWH³éºkÑÄj;ŠÅ(€��å  Šn"Á‡u­#rSMr¿é÷®p¾\\iÁ‡kX�…�½@	     r	t°˜ P@„è   nH!€‚$@ ]i,p³ÄîønT‹%–çó‹ÔV{+×UÿÑ­jgüV´“WOfgØÞ¾qXOó«Éêx»©š�àù"hÐ_»›×“‹§»ã­CÝèÚùÙ&iÙïõF¥Ù$R
p	    à�Áœr	4s `58	ÖlŽŽi=¿,¨«º§¦KPPp¹;):Âàr§›h‚(	$ ‡  .’„äH r˜iÑ}8ö¯º‹E‚jkUg”Q…Æ’ç³Žƒñ�ásÌ—W%”ú¬¯ht#ThÞÙ«£½Á�Ízvq®ymœ¡¼ÜMƒ­áí-g³„ºÔMËr#ºê¤Mq°'^äé½ßíìvéétz™/¸`Ó‡^ôÐÛ©l'-WóÓó©Å*ôÝ "Dé†LJÁºú¬ï÷×‹nv¡I¬ítŒEr¾tpÐïm·Ýfö¤¬Æ‡·÷7óîôò~uÂ­íe½žN.SûÍÖ`ÛŽÎ7Ónuµôú ®ªFãk7FÝj¹<¹\ ßôjçÕ&Vq»n¯¯'‹ÉæÒšj ¶+’Ó‚è¹œÆ ÷âN À	™›¹Ñ]’@”É�b0Q.  Pq�0ssQN
(”€@£« „º%s5è·[Û›åtÖnµÃÝ~ïÊãÅ7Ð`kgôçƒÙzý	uÄ°ÆjE‹½¾lÓÍ×/5kû£ÞÍ]mæóåÙ44=öWW5T[¥à«n}šŠÕMU•‚i/×u¯6­WËi6ôÃýƒUÊ‹Vd¬Ch6 $€Ó	Š"œN%@€» ‘„Ip‰ w€©� òVâ°ªÊ2Í®¦HûýÃ[ƒæYš/ºÜªÐæÊID„‡ AN:�$ "¹          
A#Ì!ß´çÚm¿ÝÃ|}5�é|8ß©?›Í_F.h}Xµ”‰
È%€0JrA h¢C.§ÀÌCÛoàýõt5ï£jöì`°˜¬Ã©·;G7¸ìæÝbe]¥ÊGWó�ÑöOÞ­6«´†¡ñÊr3«º¶†@¤Í:'È£"cÓ‘�Ì\ª(Vƒ«T.'—è÷¶n�ã«ù|ªIe¬ƒÄ`ÁäžÝÍ  "à€`òr‰®j›AíÖmºEñW´&‡HG—b¬o‚Êlýª,Â°­ëýiY,¯ÒRPh�S¬éWÁ³Ï—ëå,ô{[GÛØ¬Vs8PX#/ûCÝÔ„ÊºÛ˜UuUG©K«¢B§YÅh0HEË�º*ôc/BÝ|ýÚò(nÅ£½Ü¥Åòb)°
1¨¤âªë¶Òju^&ƒ¸U…ëón9{‰¸ìíŽ¯]Ÿ­./Š[=¶
ó:çDw«e¥d·6V!&®æ«”ªjÜ/@·.Ë9*ÔÁÌ(yBö’Š³éõ¢…õz�V{„ÕE@AI%#ôb$JêÜ3cìV3¦Pµ±‡ œ×(¡î�P­¹Î	™&±.u�r ”é4ˆè   +¬ÍÙ«ØºaíóÖ½¶16˜Ç½²Ð¸JÎˆm]¹mÊb•§
íVôSY-Q
<‘‘De:D:Ð!y"ªª5Óf6§«^0YÞt3“¢,TÑzY ÜDr        !	/Éà2X¬C[3H @	!4Á‚UdÂÚ³ÔY–5MlBð²š÷:l©ï”oJ×¡ Ð¢…Æ HN
  	  ‚`åŒRJÚoC[»|½Ø0ÇØôBdÉ«€ÄKQ°Ba§.#'/ïM-;B*šå²IHUaˆiÈlÉ!�jbÖ¥Ò)²70sä®ËŠ{a0Rd¨*‹VBI.Sm}šJZ­<ÓI!TnæRÙXòbÖ†è±Ó¦ä.õ€DÎË”œÞ„1š’ÖËD7”’
` Õmò’×–cg¹dÈ¨ØCˆ²éÖ¥�3³kêH+Z¦®34#‚#]* LtHww7
&GC KÊÉRq„^ÓUÒ*­‘ÈBšÁ+�
d’\F ›Œd¬bµAêJçx.™´P e&¡@$  €@Á)    "àÈ)Jˆ4‹¡ªP/+–gˆ‘�(TT ­Hï¼df‘òì™Áb´*ÆJQ©s—À Í xq/HÑY[dJ^»*´urêºä@6ÐH
ˆMÞ™Á   €(Nre¥LT5"dVòZ›â!C*$26¢³ä�u!%&Ï„ÍÌ¢ÕfÎ¼Ñ†•×1Ð=ùÆÖ(®Ê#Ai¤¼¸@Rp:Q¤   @H #  .‰„•"Ð]B¬‚EJ‰)/Áb¬å©±Úb€;Q´ÒRÅ	8B]… ªø9yöŒÐÄ6EïJAÉR)"ƒ™‘,TR) C¨¬QÑ‚§”)a¢!� 9T@£Ü‹h$ ÀL.å  dw‡Ñ;¤ëÖ-ÀB4ø&Iî‚,ÐŒ‚»@’Ë)x¡‡Ë]Å°škg)&—Ãbì¡ruÅE‚Kb`“  &!(
’»y(”è¤Ar  '	º	I"*p’9d€C   Ü�T�Ë@"ftw7ÀÜ]† º—B˜QpÉ%
’¸³:›3IÉ³'¤ºFBÅ#¡¤BVªB0P‚{)¹”à€…H!ÓIJA P 9$ƒ@ä’äÅá†`-V‚ç’sIî…”‰€Ñ@æ�D˜›»Ëå c$\YE`0‹rO Œ^J1Xt÷,Z°àD,µûÆ“Šª‘‘’K¢“ÜIBr@F:ä"    È� ‹ ’.“”K
�¹C  d$�;Å +”ˆ 	(8‰ L€Ãá# /"Tq!�*œ	º$Q�èpÏrC`d Yˆ•Y’;$Ð]477Rr‰(SF•,3dÏ¤ÕIEY±&à$HN        ¸€$±�¢@L’ ¸—1Â‚U¦h¥làÙ3Š$yñ³Êc¨”P,4!+§`±”®d-J )—{)Î"!gÕäe-/^r)î2 0p(gwDFw!ÆJÊ]$«.¥¬5Yfv7J… ™L„/IYR4’î ÌètÈ!š¤â‚H‰R@ôŠ€rR¤’ÔUÎ£™hÖD6è¬H9gÑHd­6UæÈ.1¥Bt#‘µ	bŒ’¤�B*ÙÅHz)V
ð"7„"ˆ.fy€è A	   Àå.§”K  8(^²@„ É] èpR D9&ÈÂœ(A—
É!’*’U¡bñÐŒ*’\¬1+ym°ª*Ø(ƒVÑ!ÆHc1’Š$£Ñ”ÜeÌ;”R‚ ƒItI0.©8 €’…°b]à¹«hm±ì Á”ÔU° 9@£àN@&À�¢tQ¤�*("‚.¹(F3© 2«ÀÀâ(0 xI7Eˆ0¸
IÂÝP/UìÐ¬V4°HÙÏ©ÐÄº™$w�G�f€ÈªÈ‹� ºÜe0RN3z)ÉÌ*3Ï¹È‚åR`5ˆœÌYYt¥H3ÙBîN„TEŠ€ I¢œ…b"„"2˜©tb¤yîBŒŒ/‚ÅÊ â`)ÁÔqÅZÆ‚‹Áàîeæ¹d…åV{@R�1H’“  Âîr*Èfˆd
9«*/ž€HdÏÎ*’J( )ÂK)Œp@   F˜£˜›AÂÿ›LDBASE      J  xÁA  ƒ°YãxÔ þµ,¹™¨Ôp	mÀR£6Wm	—5\BÛÜ¶åj›[2es›R¡V´Àa,rP5¨ZP­ªeÅªEËV3Š–a”•j[¨*¤ªUV¬@GèrŒt%9h#[fËÌLÑ²,£´Ü¦-·¥šÛVÛØÚ–pm"µi`F‰20Ê4¦iIÑ ¨"B‘)T+Z
¥XS©È ‚²VRVY³­jŽ²„‚�µ(˜µÔ
*³¥bJÊ–k�R [)cT¦`LJa™¬­	4V¥Œ	ª@ªlÌV#­Xd¥È”�²¦Mf³FS•ak¬ö0‘ïçBPOS      YP  xÁAnA AÃi:3«{–]Kø3\øO'âï¿?ßÞÞÞ¾¯/ç£×Ã{&ìÓ¹Òëjö¾dÛ4Ž­kVí‰u©SËÁF²K›¬3'
ˆVYê²À0m•˜ˆ¢Ž @Fj ibÚ’°H‚`0MUTAUAUIE‘%-TSE"!…˜KCUEu¡ª¢.UEUQ5QSZ)š¢¢	’šŠ˜� ’ÚRRÄ"”Ä–©©¨¢2
­RDC3Ôf…jÄbZ¦”ŒJµÒ(
&ªh¨ÁFËÂ²¦btWUZSLNS•3æänšš&«šifÊ™§¦f7µ§ÙM»½N{šÙ3§î™™Îœ}¦9kŸ3g_�ÙóÈ{ÏÌ9ë¹ÏÞÏëœ}¯÷||Ý{Ï«ž×}öþX÷½>^??ÖýZïç“y>æùœóº÷{ÚãñùxîÏùµïó™1+CNF4      �  xÁKnÛ0@ÑËŸè�¬X±‘:nÇtT ÝÀÛÿŠI ÇŠ,É2I‘=G}Ý�üV¸¬Ì‚!+ZÇï‰œøèŸáíBEO#žÁxÐâÈZY‹'£³–o„J²–#ùÝo­–Ÿd-+²––¬eKÀjiÉZ~¨dC[©	Tr oä‘qÌ+ùA"hK²	$L’eÊ5ð©¦hj±L¹:[ß½x¢²$Š¢ãÍï“�n¢/éªˆŽÄâ98O_ Žiÿ~âÒÆËS‚ÏrLƒs�iÇ´ì,¼¾tõ½?p~ÆØès÷çU¥¥ÉÝcÒÝž®ÕÉOné›ë¾?y½¬^Í–�§·Ó{s­|ßÆx¯£!T´WÕ×±J5“Í<ÖË°Uy7då.‡Ý½üÂæãx)fËU?÷Úè8›Ùª¦šFu\âmOÝ›ÒÇY­›îü0+ŠY�:(oRÙÍjŠÙTÍÕ¬BZ›qs·ö¶ø¹º)=Ûº¯b‰R�‚¤ )HA
R�?üÞ×Î2TEXT       Óû   xÁInÂ@Ð”: nUývãŽ%/Úƒò€e¤¬,È†MD!·Ï{˜ÒØCš:ÄçãaBªÌÞl×T¶Ïmw¨bŒ»µ²¨ç95°Âù(hÓÚa½?Å(ãõ%š—KB%å÷!ëý)F¯/ÑP’%ƒPI,S*©Áè4×hA2¡’ŒNÉ€ö³›Ñ×›/¼nói.¶º]ÿ¼û~Ü0¦æ©>úÂk67™Ñça�ñÔð…WÔMÐ×îöõƒK·r§¸tÑ×bŽÀ?Áš6qCLIP       	           .     ®ZTR

BASE      J  xÁA  ƒ°YãxÔ þµ,¹™¨Ôp	mÀR£6Wm	—5\BÛÜ¶åj›[2es›R¡V´Àa,rP5¨ZP­ªeÅªEËV3Š–a”•j[¨*¤ªUV¬@GèrŒt%9h#[fËÌLÑ²,£´Ü¦-·¥šÛVÛØÚ–pm"µi`F‰20Ê4¦iIÑ ¨"B‘)T+Z
¥XS©È ‚²VRVY³­jŽ²„‚�µ(˜µÔ
*³¥bJÊ–k�R [)cT¦`LJa™¬­	4V¥Œ	ª@ªlÌV#­Xd¥È”�²¦Mf³FS•ak¬ö0‘ïç  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  Gê     Gá®ZTR

SMP4      Bö‰h  xÁIÏ®kzäóº›§»¯Ykíµû]»°±]åŠ%Ëv¹Al!á”c„D$@ñ� !&�ÜC~Ê”I� AfAIì8åªÝ­ækÞþiîæ:9Áÿ„¿	R]e½ë½oú~}»í»ííîf×7Ÿß¼¸ÿð£�^ÿàÕ¿òù‹O¾÷ù�>ýèÕ/}ñá/}ùã¯ÿÕßú­_ÿð1~68ü4øïÂßâ§áÀo†Ö þ—°ÁOüãÐà§?þ*8ü#àÿûþÿ³æÿùÙ×ÿä/ÿÉ/~öÏÞ>üå?ùÙ7ßýüñ«oß¿ywzÿ×éúö»Óþt¯ã8�sJ%©RðGø?¡?Å¿§ÿ-þ€ô4
Q
� EPX Ð¨!`DŒŠB
¤’PÁT Æˆ1’%3;�BD "jŠ’PR(ˆª¤ª
	¢
U€bÅÑA¬jÎÉ&G@`@bÄˆ@©Z
QˆURDœ+"`²¹�ÁIÑ’J&)FÄT-$Œ3ÖeãrÊR*Œ1â2©Y+`)‹�b+ZÕœR&¼X
JZ¼Âxc‹É9¦¡UgÅˆDB�1^ L…±¬jN‹xÂÑ„Õ,‹“ºöàœ—hœKVUè`lÎ3Œs-L*#âRK5À¤<ÎÉÔMë<âR²S'ÞBl	w �}öô¬²]RÉ½õµJ™³äFZ/r�éâàª¦�\–k´¨1Ÿƒ &ŠCÛUeIçmEax	¥D@ýÊYNñê¼¯|©³QMv©}g},çœ¬‘ZÅ‘¡A]p­ªvm«rœâRÙ¶òjDþ e‰Öu…T.3(Æ8 %::_ká²(j1^�(“šª¯ˆkÉ*®Ö}Ì§S2MÕ8ÃKPF\�ÛnjæÃ86CÛ™E,4|„hNúvÓŒó¸_Jc†>¥ý¼ŸŠéêUÏzšN#V¾ƒË†Ð”éVëæº?L¥ik!~˜4³^wõótIÉ¬ìÆÖÇy9£«['†¡AÑGÛÝ­ÚùðMbÓ¯‹5þ.H‰d{_Ï§ç=°lQ€á08L˜ëûÍpýîé]ú
”_€-3KßµLçk‚kÚ�>ŒC?Øj!¡¦äó¥>\ééíûsmîª~u¯ããóÙ­ÛA©R ¡JZ®mûÑŠ‡÷oGy¹é¡YÁð¤�Îsnîînß/oõuw£È¢”ðG €2ÆÔ¯;÷æúîù4¬Ú"‘
ƒÏyûñ§�¾ýúi¼ß®sQQJè@è2¦ÍÍËº¿9œ³ñ›¶_�ËóáX7M½8%Ã÷@ 9G[¯+?OÏIëÖÝ¹U¼>>-4AEÀ1™þå‡¯ððî»ËËÕ�‘Y¤@Â+¨–qžë�~iƒ7¿øvúàÅ�MÅ(%ü6€#ò°Ûx÷W6}(Àð
Àåbì‹mŸçzX[f€á@™rã×•,§ñÛ··¯Üu¿?³R¥@Â¿Ò@çöÅÝÝüîñq�›µWªRBRD—‹¶7îÌÃ7ïXolN`	· (\®¹¾}ÝËÓÃ77«ŠE¤@Â ôš–îv×\ŽûØ¸î¦ªÒézQoW«››izž�ß¦(Àð» òqµÞ¦ëóÛ˜6u%£!%ü.€ùe}kñæxÌqµ’B€¡ƒš"%)šW.ïõÎ÷�R¡¦$]\½�œŽéÚmœ£‚¡)1ª_¯Úr8-êÑÕëª]®§³iWµÃ÷@P˜âØ¬îî§üøœª»µa¥„1-®½Ýe¿œšÕ PBÅ¤8ûíG7|óø³GÜíšÌRÂ—  %]r3ôx:ïÇi^Õí`Îóù0¥Íà=H�æØÝÞÔåña_†¾•‚áOAÂp>]ÜGŸxóÍÏ€_½ñ×œJxÒ \ãÒ¼úãó{òƒ¡6y>!Múªâ|>ªÚfÕ;3_³ö�É¢dè¡FUÏIÚŸèøðö|ózè%)Àð€sR·kPÏ§¹4Øöæt¹^b¬�ß²š¯û)µÃ 	 Ãÿ5Ê†›U¿Ï±ª{uY ¡AÑkÑõ}ëÊû‡o}3ô&�`øH›Ó´È°[7ÇýáŠÆ÷ÑªRB‡S¾ÝÕöt|~ÛÖ�+(
hžhúÖè|XJÕ9£z¤8axix}üfF·õŠ,
	ŸC�j>O2¼ZûËã»kÛ¯"‹BÂç ²¤£Û~¸Åøð³·±¿sn‚áß 	Ãé8›O?½Åá›:âË¥Š„ß)K±~µêOãÓiñ~U¨`è@äiòþ~çÞžÏV	¢Œ
·¦Ë+ßhx	RÀù‚õ÷ýÂ¯Þ.ýpk
T)áÀiYê›~Ïo®óªÚH$ÀÐ‚4Ð1ëæå}cß¿ù*ã~,¢”p
Á¨jÖÒt¡4­¥-døu¨)’KjÚW^/oŸí‹­G$ÀÐ€ 0MÉß}´Š‡ïž3^¬›R²‚¡!ZFWúMÛÆãé°4ƒ2ü�6—å
¿ÛVéðp,õ¦‡Cÿ ÀÑiµkÛ4ž¢úÁÚb¡¡pZr¿¹E:^]µ©|ê¬šá¢—eÑÎ[¨�†J‘IÛ¶�ÎûÂÊ¢s‰ƒõ€*hø�Áà£š»{äwÚaå@R Kšüð¢58Ð5�£À´Lnýbµ\žŸÎvuc�÷ @Knë8MKnë�…áG (ŒKtÛ�†õó»wÏis;HJ~(‹ïkŸÆãr–¾Y­îÊxºÌrëª�†ƒÕeQ¿]¸<žr·i@P>!ªSÌýn=<�ß-O¯Ö­ÍQ á% ëÅov+==žp¿êl’"ŸƒBÄ¢®«*L—óœ*?t§çE}×@¾A“0-X}p£ß¾ùæ?¸YÕ“ÉÂðç PY¤kZ3�çkãëŠR„¡!ZF‡u¿²åt¾ªµvU×—eœ2Zg†U§Óu¿.u½0=>ßË°6&(Ð<UÛé<_�Ø®3q¹^Ö[µY¾ƒCŠ¶¯ÚUüÅ›ÇÜ¬·R²�†ß…¢óªÛ¦ãt¾ñmÝVHó¸Ìj\·2Uš×Vm³Ú5jŸ÷cAÛI‘"¿‡e™»Û{yzÿæ„ánhët�Ó4újC1¢Ô¹pèZS¦ËÈØ¶«ÝNãþÉk¿®H¥0ü=PPÊ6ð|¼¢í‘BaxBXÊ	eØ5æ4½3RÚÎ”"¢á"Qmµ±2¥}+ÓVëíq<`¿uÝzýÓþð¼°¯ël²0ü(P�S”Ý¦A>>?Æn¨m„ˆ†?!ZFIõîf3OÏ�9nÛJ‹„(ò¼”ÍÍ÷zxÿ‹(7ëÆgÑð« „%ï‘o>¸Û™ñë§äÛµ7QÐ¹LM³k ûãÙ×«J�RbŽ¥ß­ÇóóÔÖÝf}ƒëa¿·ºLa†hžŠúmËt9#7Ö;!(Ðe¾ÈðòÈáëo—8¬w”HÑðP@ÍGÕõý0\žÞ/u³’K†á%Ñ2*ìæEµÄçË9×ëÛõåøt°\5>™,?9f˜¶µ˜—‹ÁÖ8!)`L×äv¯ï–ó¿|Ø_K×5Z~ÄÂÑºÍºÃñ°?ç24u19ühJˆþf[áq:VÍMk“P4|
4O³©·Ûóñp)qèjµÅ„@Æ¬¶Z×½ž±Ô«ÚRHA™çÑo_ow|÷öç,ímm˜m	?ÔGø×Ušß?¿_¸kWF&#ß‘5Ám|§ëe¦¸mÕqªºñhø1(„$œTn_ÜáôðÍSL7·7÷àÛãñœS_wª¦„?€–%Vm»Zòr½dl\—%|	
”.~¸ûäæñùý3çu³¥*Ãg €e)�f×÷q:.ûÙô®‰>„êœ+ßµ~*§T(Uí¬†TŠ‰4ÚuÎäñšÞW¢"á÷AÑt‰ZmvÃõét:‹ëÚ*³˜ZP(:_r¾yýévy~óvu·VU¨æknv²Æùé]2RõP( 0~ M(lšº‰q‹±Î;ÀJø}	óbš»ªµËñqA\umqEÂo€š"L³õÂëqžKí[!LèA�æ+cµ¹7§ÇçhÐv°$!á�© 5Ã¦-§ÇÃ¨î;Êe¯È¶ªQ%›™ìâmí½–tÍ‰¦Zõ2]Î×³­›U6�‚2»z·«S|>z?TN(…jP™Aãš¶‘´—è*g+ª„”X²Ô»û­Y¿{t@Û›¢¦æqýææ¶»<¾}¸D6í¦B¼äkÉp¦²
«¡�”—±Z°qÈoß?ù¾[YR¡Ñd‘US_—ërEÝÖð0ZP¨Ì�bë†6NËÂÆÐ É(¹Åj(Ót9Î±ò~UÛœÓyB1â]ö™ˆð+ ™5¿ÞÝxúîiö}×%	H BJ±eQÓ4�—rÂYÅÛ
VZòâ¤s]–y™…ÖTÁ	J¦ë$#GÍ}ekÑy¾Öí`®ó¼@Ô�SB4í®Çùòæ�­ï[Xhø}h*©ÈÐ[©ŽçÇ´´ko4‹RÂ *¡%©ÖUß¹|—«—Ö;›�„[G0çTÙÎú¢K\TÛ‹,œu2"Ö‰ËÐ¹$4C[ùxÞ/É÷}Û\r¾Ì„ÀY8U— á÷@Q@ç2Ãßô-Ýþ|òæ¦®¨¦Ud‰FZ×3e®¦Ï¥$¯�ð ¡P�NÑ³K%/ˆ¨¬ƒ¤2+ÅÔ}åf}VF�„
$K^ÔÉP7\âU´k\±–"aBUóâè[+%Ž#Õ G	ŸAAUfÉÅ{k4]ÇbW×ó¤ÑÁõ®V^ãhlµkœ.§3PZãé”F
”¹dºz·jíuzÄn½òÕâŠ@„aEQ€©¨VÃzk§ëÃµZßZ‘SÂTQ)9Ïb\Ý3MšzßZ—çXŠ·ÎÀ§4f#»Öà8§TU®P	±*þH*4GEªšÚ•ñz:)Úvˆ6NË”±¾4j ¨9ñNRYÄÛÊ /	â
³«ëÚig*ké‘àA²°DMbú®)�Ó~y}ß´R–8G©«¾³˜—1V¥rÎE±€fµÞËHšÞÔjBEQê‚Ä¶ªK^Ž1ûÒv-ìœã„Î¾§IËá}ÝÖžr™§TUÎ:5¤ÒÐ–ð*,È…®ñ>¥yž{aC£%º"#á¿Jdd)uÓØ˜Çsôê+C¯ª  	?Á"Åj1Ry#R´d“a<­šBM&Ã;_À¨Æ$üT
J”èÛ�óeZ´‘•õ9Ç¨Î‰…)
a¸AevTã<ª”ç’=}ñ…š «á¨(R4Op¶mÕÎË)ÙuS;•bJ1ÁAA+°IK¶h+Oræ5YS7ý™q,jêÚÃ˜\˜+@ *B
)¤�BM0ê¥"Ò¸,l«Æ˜¼\Sö€·ˆ‚ •€ˆ-­úª*ˆ9&ç$�9+0B@E^C…–h|ãÀ<ªÐÚ¦TÑ$C	¿	„*EKYDºª.KšŠš^j€†
¢¦°¤kkQÄè“µÒPQf“UD áC�P£JñE�1 �šUi„FÃ¿‚…jN“SïË4eÀHmÀ,ÑÓÐ*!`èA$TÅX‘\`±ªŒÆóë«Úæ’’3
oÄ)t)…ÎûEFSh]][rŽ‹ª³Þ[Õˆ¢•i�g‰d±b]3	X‚£0¼¡´
QU¦jñ¹®]'	Ó\(¾r©À1Æˆ’„US„P C‚Œj1N„y±I¬ƒË‹ø¡«ê<>/óUn75çå:t½4°B¢P…ÁAE4SP•È@©ÔÂ
²SZ	JˆfÀˆw‚H�œ˜‚BU˜R/Bo¬)U‹Xï­¤rAia}©”šs¬hÅY2GVj`ªÄÿ
ó|ˆ·E•AGD(B
¡ ”( A
¤
RThTÄB!Q¼Bƒƒ…„
BàhaÅ@˜5›\Š'! ‚T(	#Öˆ3 ´ä”R¡'°J	ˆ
@†
¨P€B! *PCQap €  E”
EHCBUKQ¼±`•DÊ0Æ8
DTÀP�Bƒ…€ EUsñÖÁ’y�8kŒ†�Ð’S¬mUyŽI¥F•Å–ð› ´äÅÁ·2_âb-½ˆÓðŸ�B-‰p®«=.×iÔ•ú,†á3P¨š”Ö®Â4��6ôÆRÃ÷AP�˜ºu2Å@ë�L	Ÿƒ F£ààº’æ“èàœµpdèAQ)R@�ƒ¡K.Xwm÷0?E¸Ö{ Âð ‘«Í†—ãóˆÖõ*ÅBÃ
ŠjD2U#‹^–ÄlÌp7@Þ?_ìÐîšá||z{Þ¹]eXÄ�†eQuCgÊx9ckúõõõñk¤~»$ ¯A¡&IÚ4”tM‰ÎYˆax	
)±Dßöì§ãs‚øáf%—Ç‡}Zõ+˜h@
2)ÕªC¾îó$5ÛîÖv< ³u·6ËñqŸüj]¡@ÀÐ€ ó¼ íw—Óe¹Òw4B0ô ()Ç¼^ï¶Óô0F;vøåõëËãw_ŸâËvXßmÍåá+ŒkÔ·÷ÿîñgó¾o6ýý‹ñç‡úævg˜¥@äœ·iÒa<ô¯n·ÓÛwocFõ¢ÖOß�ðý®÷‘ ÃÁà�Šb}óZß?¼9›aÝ)`èA eJ¥Ù5r¼>OÒöU�@ÃŸ‚Á!éµî^6iÿ¸µZI”	‡”gß¼ÞÊ»Ç'ªY›Ýß=öÎ¬šÛ{žò›¯hî7Äl³JøC�FÊ4åawwûîÍ›§Kóbm4ƒ ¤Ä„zµÙ]®û8a0i³Ú=_Þ=Îü¤i‘¬þ6æ¤~ws‡ññ¡tÛµh^‚Á!§\7¯Ž�_7®ooÖk{Ú¿[à†“U2üj”åÊ´½¿ëŸŸ�ßñõ00`è¡FY.©[ÌÇÓéÙ5¾-(døG 1�±»¿o›÷—M·QJø1€iNMsßðáñ�n5¸œ†P¦ìëmŸÓátL®åêæc�Oïß§ûf½Þ}4Ì�_�Øn{›H
ò²èðª×òæôl†[A¢Hø2é\mº5N—´Ô½/.‹†ÏAÐ$½j³¹­âéÝaúlµU€¡ƒeŽÚWê/ûcÓ­J	?ƒÃ$K½¹­§ëÛkºz‰~B”9Ò®:«§yäÚß¬ïÇwû}îw+£P2ü
ói±«6óéÍãÉù¾RR	ÆYðr½ã7ïÇ±i²¿yy«§¯¿;¢»­7¯êõã·ïŸš¦«oºõ~ën?Òáý7S·]U²QHøm.SlW/ªñøð´iÖƒM :08,Yûa—çééí¶®r~ Ò å…ýz¯ûã(ÛºÑ0üG ¤äÉhÛØã(Š¥µë.ß~}�Ó«Íêv»ÂÃ»Glvƒ–B
�ruÆÞÔ×qÞgSY¿þ >�ß¿;4õM…œE!á%(É]Ïýpßõçvj›oº™áÇ DS©7­]–s«¢í¶rút8·ª6ëuÆáÝ[‹a(’ †Ï@Ð$�—j·µöy‘Òu6`ø¤AÊ«[¬Ïç§i¤±ëmõôôþZšÞ!gQHø	€S²Õvs=žSÞ´m¦‚á%Hƒ|¥v·Æ§Çu]}·�¿}÷n¶w+§T¥„s›Õn…ïžž£[­iÀð%(,ñ,ýæÓáÿÅ”nwës{Õð9–¸øîvÇw��ãªlQ%C`>ÏvxÑç7Ï�©Z·†P¥„ i,íêEµ\žÞ®úÛ•(þ¤‘\²4››~<î—sß´X¬jè@äKŒíý½àñá�kûžP&�]½ªÏ×ë¨[#€†€ ¸\éîîºë›Çç¹]ïnWiÿæ©Þ­:I þ(”‚‚zãëe¾ÂõRK�0ü» ”jú—XéÃeÛFWWaøDcŽ\í:<?,ïÚ¶“ŒB†jXÊu±«»Í„Ëã³kë*£�á÷@¡hTÖmåb\Fé¤–dþŠ.¦´M«º\iÑ{Ø,B´,“ñ·½Áa?]»®)"1�¾õ	®Ï�ÕÝMg#Œ‹Ö7q:žòÐ´ (
B)Ev/:œ÷°ífscø°_Þ›®i
-4|Râ$²ÛuÓå8ÎÕºóÉdPÈqÖúåîæ4¾9œì}5Ü¼‚‹o£_õU¢R˜–ÉwSÞž–Æu›CL�û«­z?Ü¶ÝáòvŒ}Ó»ÎŒ§Ç«~�¬E~ B1�Muû²Ãùá½­WÎGQÆ%·ý�Ô‡ÃåàV�/R„áƒ�’&©š5r<ec*ç†Â´,v¸/¸ì÷ïeÛëuŸNç·“ñ}« …á×@ YÌf×-§ýsêoV�l ¡…’²æÛn�çë~¡ì<Ðð%aIK®·ë›x=íºVl6Ðð
£NÕêÆ)žÆ3J?¬îé¾=¾�LµjÍ""þM@¹¢4Û-æýáâë®@aø„(â¤ºÙõz~:H½Z9†„hžf©n7v~>ìÙ¬;£( E—8V›V||þf²tÕzã�Ó»Ãìoû*K’"ªyŒXmÚîi<ä%»j¸}U–ýûïÐ×ÃnÛ”yÿ|9Z;ì62=�÷¹z›L†€B)˜Ù«m9.óµ¶�
AAŽIªn»�.—svCUk1¢á�A!I«v0f¾^ÐøÚX 
rTú¾ªR¾\¬m¬Sˆ†_yII6CE3>î³iQ„¢á¿%%a·m'?>Ì‹ëê*kø3P ©vÝHžGI[Q	ßMj«U#órFê­34¢á¿¹0‰ßÔS§)e7¬n[?ž¹ÞM‘0€jÊQºuÕçÇK©›º.¾
r\”«a¥q<?O½Û»^yx:�«¾sÐà¡‹–¶*;-çyv¾qFÃ+P�ÓÓùªÄóX<§Á¡,E|³Ï§Ã¥m+k²M( ¦eA·kÏï®§]ÕÞ®ºŸ�Oc×4 hx
ÊRbçvÖOãˆ±n½“ä
¡±ínðît~Î§¾©ªdJø$�Îö+ôù|<L�í”FæË’ÚÕý*—Ç·WÖëÞ›$| 
óBô]åq½.
k½À)Q–B«]e¦ýeÔ®î Å„ÀqCÛŒórH®©+«b4 Äˆþ–5§ýt«®-¶˜ð7@�³±ý®¯òéx=¬Ú¦…ÍFÂ
ä‚Òù¾ç%ºÚ9C+á5˜XLÛ½œ.§s’­¯Ä	+P£f¬ÚõªœÆ)Õ®s0�ð .
Ó´MÖó|½šºßZO—‡sDÕwêŠÍç˜wÃÖÏ—Ãé˜±ÝîZ÷|<_[ôƒ³F!ß‡ê”Óªš4N‡+è}%
ÉTàÜÊV%^³¶ÖXW¬	ÿÈˆhëŠÕTN1ÙÁmÖ¯ÝãùýùÂÛ~s[Ûi>LÏ¦i14Š2’®k}š§ó’jÖ‚^ƒ9Æ\­ÖÝMu¾>GzSUêŠ)"¡™LÛ¬½^N§ãQ6õ®®šýñtÍ¶ká3%l@fYZé�"�9y'Öˆ	¿jDvn]U:_Î©1ÖTÙ2|ÌSI}³Å±Nsö�7^¾-SQßu]¯×ýøXúÍúäøšÖ „Š„
¤ŠB#ŒVM™Ç©o��µ"�ðŸ ”E�Ô�CÊÇ¤Þuë�?Æëó\Ÿ»Ýzð-öçCoºÎú+/AÆ²H=ôyŽ×)±³•±THøK‰TçV�;Æãr<É®Þô.¥kŒç*ˆ)‘ðX’&‘fåPÆñzV¹_U>>UÃ¦õ
Ãk¨ÎÌÞ-Í<ž.°õÐuÑNËt½˜Í°ên$NÇk‘­ÙylŸ¯—¹Øºq–p~ZRFSµu™Ò½ú
",K´Úö›Ú.§Çã¡i«Ê’H¸EóXkÓ76æë-z©“KÐÅÀùÁ¸´ÄC’õýmïãéù”ê¡@Qaø”JKG)Q(ÞÍ²X¥-…F¡´]__Òe�õÎC@ á'PÑ¨I°ê¬Äù8)*[Ã†Xò$Æv¾^8ghS<ÄPÂ¿L%;7t+-ûóað�³Æ¨-"áû ÊDÉm[××r¾. 35\†„_†–h¬´¨©ØcEŒ@$WÔY�¼(]]Á,IgÖ†Hø]M¶˜ª6™1Æ[§–á¿5
àªÚÆ<žK¤ªŠcx	’	…¾Z×.�×SBÕ:qdp>U´äôU–IjÕ7•+ãi¬oéŠˆ‘ð¨Jª&:S·Þ¤eÉÚ[xK—`(V ÌUœëê&á|‰ÅûU]/£^ •G¥"0" U–	Æ´Mkæå´ÌÅµÆHØ€JR!®ëçé’1T¦¸H1vÕ¶’ÏûcjãhE›�ï,Rºæ…nXûršÇ+²O_ŒŠ„ßƒ*”%O&uMÕiœö9W¾²¿äS²]]5b¤ˆP	¢h,tU[»¯—…hW�Å˜¯ uÖ¸l„*	¢�,i¶èl½N)WV*+”à  © KŽ¨ÜP9Î×ÈÚÕ•qÉ€"*€
(º85­ÔLq™­±!$ü48Š‹µlšJªM),ÆÕVR\¬O0i±Æ á×@e¡ˆ•lèZ‹i³w¾€4¾³Žç±ÀIm"
ÃÿR`Î9ëëÂr5•©=M)	"F  Àð_ƒPhI&£55JJÉk-¤äœÉ,0®ä<Í´�Jm‘ì¦‚¦Ù˜
ç2¬lS{#sœOÙV«aáOo�DHF—ÕµÇ˜ÈZ*B@ Âð1YRÊÖ¶¥J9Ñi%u±(È®L&KïšÅÌS¼ÔÙA aøARH±RÃHÉSQmlcÌÑˆ!!áC�PA¶Y¥A•dÑ\;©-(YM¬!–B0¼)€P•5¨Vå:Î“¬†º>é²\k5ôŽR%x)á�

F¸­]Õ{ÄežGÓ4m×ëešŒéZ8“˜Œ-
1°BÕ¢ÅÒ	Jžááœ…²L€¨ÓZ}Ñaa�Í)
a!B%)¤!Èà á7¡šU�³ˆ@‚·j²KÆŠ„D!In‚kê®àœŽ%îê¦M1ŸSDí¬Øl2Y@�&  ÐJ�]æb“75ŒV¨ÅZÕ¼£0ÆŠ5Šˆ”Õ£¢D£ê�…+}a„2ÚÌÊza™–TŒT©**�„$µ(`¥Ël²4Ð…Vl-™y¤øâXEœ‚�p2›ÔÆ‹äYÕK! 	k� ETKò¨=“j¬­õ5}ÉÌŽÎŠ,(j‹¡%¨¥PŒ1@!Èâ®µ†ÔLµÆPcqÖ´•.WµÆ“eVcÄx¯šð|˜B¨�B
… 	†€¡!E B¡ž¢$Q
C¨€�Šª¢(
(
Ñà ZP B¨"*P�
…R@ „(Q€BB
T@
¡ÐàiÄ885†drÙh!E`  „=„P �Ba¨ d¨@apQ)PC¢¡…¨@P@U �÷ (³IFšªÒ¬×Eà‚3`ø1(ª%ŠJk›\Ò’rUK•-Ö ˜s‚õ¦�§%•GEaøŸ@ IfSoo†ú|xÔÆÁ×�Å¼\ŒmPÛd¡á‡ @Äibÿê“m3õö-n¶�³¶÷e¯ÚH'¢4¯@ 	sôë­`:<*Ö¶W@Àð¥”eqÃ¯-¾þëSjÖ¶®¸–8‚hj¡†„Æ4ÛþÎ­ÆãþhPuF©`¸…`J*~w·ö��Ï‹ß¶V"�HøM&wiÌ3ïîVýü´?å›¶ñ…b³JøæÃ’^~öQÑ¿úêT^¬7&‰*%ü.HÃrÍúæCy~:þívÈÌ CŠÂ”cÎýë/ßþ\†Û�Ú+ †¿‚B=-ËðÑX¦_äÓæƒ5b)¡ƒŠH¹òêÃ�°¼ÿ‹¯ñò³Ût^ `¸E¥”óä›×w«óÓ·GnW�Ÿ«ØÄJÂO@‰:ÕõË†û÷o«nh%«Hø…å îöãW9¿ù*/ëÛ6ç)�ð[ Éã·þj�¯ÿò}Ö°Ú¼XŸÊ»G¬VUiÝN–t¸.n¨›¤þ>ÔyšýËOoìÛoÏx±qºCC=/ËîÅ÷€7?ÿ.µ/v‹QJø5�":�S{ûù€é¿ØcsoK=4y¹Ke`Û®õñzÍnÕWŒš¥Ó„“éï^ãüÕÃWøø¦7Z	ôš&Ó‰«!èrµ~{gy<^“t­ÌNÉð‡P1LË¾¬?þh˜ÿå×óÿþé—k'R�'ÆÚ¶K�Èðc„¤8¦»Ïn1ýì«„æncŒRÂ‚ �–Eï>¼]ß~}Ì»Î›®_a9�ÆÛªÒ"`è@ \®ZßÞwË›Ç§¾½\QQJø ÓY¿¨øöp ¿ílÎ !’–ˆ—½ðoÞaXo�”þ¤H™.iu÷q‹ó75âÓp�‚ás�2ÏÉ®ïly>\æÒôf1J†{PT˜ôšû—ŸÜóôÕÛeØn%±…ù�íðÑ]»ûn×ï*)ÀÐ€¢0å|¾¯�o~ñóáí}Ä›UÂ¯€„`>^û»/›üðõ?ìïï—¼¨Hh@"^fÝ}Ùãñ/~ö5^Ý¯­Z[8¦Ryç²�†BE çk¼}½kÌ?ÿæ=ûUO×µÕ²\È¾«l0¼pµ[½pz|Øk³ZùD€áTDÊx:·/>¿Í_ÿõ_?Þ}U×mçÞ]ßŸMÕ{;¹¤~1_Üêõ‡»§÷_íÍ¦qÃçP£Ì‰:ÜÝUéøÞØU×ªHø08ä8šÕ‹/®éqÿý0Ø‚á�@P8Ï‹Ü¾ú0=¼3o^4­u­óqŽ­�ë¼Gœ£T®Ñ*	ÃŸƒ óÜ;w>?êÞ‰­*Éóin1hUCÒP–ù\o?þ¤Î_==Ë»áœÁðw@’¯óä?ýøîŸ~|tgì¢
†€B)2—º«lŒc¬Œ©ŠÏÂðC¢LÅúaÝÄÓxFÓúJ	†ÿEÓ!­Ö/k¤wo½ýhè|åJ™G_Q J�ó	þå‡6~÷íÏØ¬7VYÈÐ�Eœ6÷óåmZ­ëšÅ2¦¥^mv—q'ÛYS7^b½iœ¨QßAÁ´ŒÕî~›ï/ÞVÕP“›ö«¶m‹ :¨Q–sÌ77uºî÷v«V©R áï@�²ŒgÓ¾ü¼:�O_¥¾µo…z<ÎMmšÊyŒã;[@ åJmo+ÌOç£µ]«€JÇd†—w»r}û.6ŸÔ�ñÖÎz�“FÔ0¼!šJ4~×çùømµ±6RDuTÖ··f9½=ä®­j4^ò’&íŒsÉ0¼)ó4onïÖøæáÝl·½E"~
—)aõb‹üøîáüÑ®m]M×‘Î©u¾BŽs"Œ6}›Ór‰ÎµM†Ÿ€Ísôõ¶ŽñzZ`;S±Ãÿ(Ó„jûª‹ûÇ½ºíà“!5´  Iúœê�íÓw‡¯ÿ›×w+W²‚áWA”ù¼àþÓòøæ»¾ÚöÎUÎŒéb;W¡ª¬+ù2•ª©\1Á�ˆ)u~W¦érŒXyëŠ/@@Ê8Îþöõ­ß<Dìv•‹0Ôð9HIÇ,»—¯qxÿn\û»¦öU¥Çb£á …RÊ´˜W/·ÓôÝ·¦Ym»Ê{�e^F¡˜ª±´Sç‹’Ëy1¯?²ñ«oß ¹ÜLRC
J´Sëz—Óu”Ê×j)þ>(Ð2ÅR¯vRíŸ—çb;µYDÿÿ‚à¤Wºõ<ðý<o³ºªÚU»û¾Ó¸;ÇÆ„$v¤È
&	H–% P¦™1a�bÀ`‚Ö/‚?�bœÓùkvW»ºµÖÛ<7×5þÂ:óÛÍçåáåéUóz¥Å™ØØƒf.lÖ7­,¯�ÕÖ›YDlü]�z9'÷æ³7W‡�ÿøî¥]_ÇÆ‹KóòêÍ[ðƒÇ²\�w
¡P’Ího®Ãeÿñ<áÚG	Þ¡Ö‰æÕ‹ÂÆ˜¥baXÙ)Ù¤uÃJ÷Ëåp@³�Ž
,gXƒt>~¸0lš&k�åtÑ¸»óþaÿñºíULl¼!†	—xu»ò/Oï_ã°mzßùãrY.MpQª(Ll>ô?X#üß�æ{tkiœ¯¶Ì%xu¾’ê±¤–‘20×âû«–<ïOKÒ¡Ùv%/ûóI»!’±ñoAK`è:�9� qP'ãÄ¢ç^¯b³¤Ã9‡¶a0¸BÖ¥ÐMÄ2/¾éúÊq
JÊÔv»ùxx}9¶qÝ´1ÔºL©åà)ãOAK`ˆ½º©Ìsã]DÈP
S™uý¦uù°?_ÂºP¡ã?Ë”«ë×ëíËéuIÑG«çø)X—tèÃrZöÅ|Õe
j²Åºí*¥e~=kÛŠT?Kž‹�CyMçÔÄ¨±* Ö‹Z?ìŠžŽO'ÓûØš‰Œ Ö´ 7±Éïž'Ú7Msàrœ#ûè|‘ñ�AÖ¹8×¬�yZ*}�`*ãƒ5¹Ìf ê’M¼/
-Õ–Ì®]…2/'”ƒH–ñAK	+×Nåt†“6NÆŸ‚e26ý:•ô*ýºÇ
¬^dê»Ý §×ý�º�yŽÔ²Tëš!6çòº¯êœBÇ+˜Í´®ª?-û% k "ã
DæD¿Ýn><½ÎˆÍU}]òYjãC ç¸�eûU–ùüZ´wQPÇR°LÒ\_7mýøümAÛ:-Ðñ
¬ÎZ-×c	ÑdÜÀl²Ûµwé2_jmúa…©?Ÿ]3˜Ò‘LmVâÒ|ªB#„ÅJIC¤äÉRHÎum/å��ZãÎÆŸ�ÆÌšWC¿ºèáxyeŒ½†¢:þ{°¦*·ë›²™?º9MïÅ$ÕT©-¼BÆÈb¹ø°õ0OË¥qëõP›y~–Åzá³…j>j>]¬•ÖKõ{P`™¹¬ú5ñ<½Jì|_ –DÇ6z™K-¾F�¦ã aV¦š;µZŽçËáì\ï=PŠMfC‹˜Y/¶ø"â!³Vg]ÛÒNË+—Ð®»Þì²Ï'»àI�-9!nv±oöûKÞ­újª�ñ†š*ÚØ÷YÎç¥½D@„ã=ÈzY2†×âáô~.pBòÔñOQë‡!4uY¦É#hW½Œ?ÉÊº�êÖ}�óqŸJì¤S¨‰@eüg *-³v64«²”ç´HÛt}¤Ì5-FqŒE@,…y®ï»ÃáýsÓäõUhVæ© ±ó]õ9•âµzSï@²æ
ïúÖsJûy†ºÎ«ä:-Å1FôT$±"ê)ÂTÝÕ¶�žÒ£oã`RDdü)H³2I	Í°n�^/Ë¹®úØÖ\çE|¨>Kò*nü$kM>õ¡‰.•ó9ÐµMP-,Èà`Niêûë·�o?<�Ìú^‰*´rI¥ë×7šÎ�ûºè•žÆb3Bß¯æé²?½B×±¡3•±�¡À*ãª‰~Iû	1¶Ñ	¢2þÈšç…w­äéòxÎm}v„ŒÿµNé:Õ4Ÿ=‚sQMEÆÒÌj6‹±kƒ�—×…y�®cXê2ÕÒ„(¡@ê…ôÔŽMu–Œ�¾Š%…¨Êø}Ð@ƒ•Bç[€)'Ht
Uõ²Ìquuf}yÙs·kš
hM©„f³5?¾¾ÂÖ~hµLÙUñ^DelAZ¹$Êjx~ÞŸæyë#*Elü´ì*£8¢U(*
@ÆDM2úXçy¦Šªxƒˆ€ ÁbC;”e>§ä[í¡@EÆÆ„b16æ¦ZèEà´Rj.EZß�ó²T‹D!ßÂÄj]*5´½G:×‹ë›Æyš3ÿ)HÐ²Ìªq¥2—<iP‰eü{Œ�VCè»¶ÌË~Bmb_T)2þs˜°Ì˜5vM¨óñyÛ!Ùù8)]
¨¨Ž“­f©>tj5_X]�ð€Õ*(€xªU½Hµ¢¢N…´º˜cb˜°GuhÔÕ�-(f‰U¥”S:–F%"´šá|èDò’|•@u7 !b´%çÆ­Ú5ÎçýeAb(b¨Èa¨³1è¦uºL—IÅk  "2Ff¨	‚¦ñ®LåÔT‰�yèø#„€uÉ}¿.ZÎ‡5ªƒ*EŒ2þ>HKR4t^æºL¨^‚ƒ(eü=�¬dÍ±Ù ÙŸ÷§ýàŠÔ\3 ˆ½Â¦šçÕ9Š•JˆŒkYµZ]ªw›ÐØép>»«fˆ`®S#b¤™7 AÂX<¤¥Ï–ª«ô¾d’ƒ�-D@°fJpMQ.—¥hÛµÁ/¶,Õ´x5Ð„ƒ‘j´äæÐ4�³tÈ®•Ð:ŠË¨ÈÞaËr.¢ƒóZ¢@TÆ_�T,ù‚Ö7b¹.ŒÞ9§V\öB5GÂ@³ªt‚lTé[•œÊ”»Ú6+áœ’‰Cq
!&2Þ�€hFV[j�ÍºY¦ùñ¸h³éZe®‡Z‚"8xƒ±Èäk­Ô|)¢mÓFM9Í¨‘¢TT€‚Ž¿	…"(CÛû˜Òé$ð1o.‡¡�T ÖE½ïK¸Øœ£óðF+eÁÒ6Ñ�ÓrŽ±ë¢1Ÿé$!„	@ÊxÂ` …5[uMß‹œ_/EúvÓ¡Î)MR‰pTÔD‚ƒoQç%¡o½¨˜Y1!€)ãß€0¤B5y:×VÍKY€:1H.¨*ô†TQ½h¶³ï\lÔ%›X³¢'¥X±âRÛx/i9Är5´jó9…\*«T­0ŽHˆ��5Uï|Ôº,S­Ž!@`¥é*Ä´@Æ_�¢ÖR¨6‹Áà$ˆ+LµD×y`±¥4Î95µB P%@Hu*Vkµ* (ª
¡ïÄ+� â¡ŽRb0BX¢êÈâ`"€Š˜XE©¤™T”°j@@`©U4Š«f:ˆ€FÂp&£7ºªf•4@�³­T…¨óË®Š‡#HBUíøÅÿþY� X­Å"€TcÕ*2Þ€„Œbÿ]~÷+Èf1qP�ÀdP3!Ä 1@LÀÑƒ !&0  & PA01P¡ÎyWÅX|-µÐH@„P„� (0Å£À´ˆ™€h¨•fqÅÁ“V)‹7šš¨Š@Ä „	…Â±&ŽBB*YŒf"^ÔÓ±.nÒR½:¯ÕeY`>Gˆ‡ˆ
 ¦1Ç 
Aˆ	`BáØ€R( AŽ-„šŽ· ¬”ˆmÐRæ“+-ÂÊ5óÅP½Sç2þH–‡6*,¥”[iúF=/5íØÀA9þÖ©®i])SÍA;?4^Ò4¥ZZ¡­–§%FÝÄf™æý2]T…0	ëØ•4�©Òx áø„Õ’Ø„Þ…TÎ*ZUxrlA¡1±:š.åãYjÐ  #Ç_T¥sjÔ«quÜ€¨V³I«Ád)Y(è¢w¶\ª9i«7Ž;°² Hß­‡sÚO‹ö› 
Ç{@¶‹ù›Ûíöðôô!£}¿/‡‡Gìn{_%ƒãOAÉÍ^u×ß„ãôphü°}¾;×ñÂ³ó»î�ž_²¡kÔ5ÿÀœæ¥ß|N\¾ûú€Ýfð•Ž”ñ€ËröÛû5ðôþÃâ¯vQX””‘[�"u>¤xýå=–_ÿæýõ'=ÛÝí–¿þõ{{Ë4pü¹ºÐ¯óþü²hÛ…`Ç{˜ëiF{ÿVö�_U½é$ÓÀ±0/—vø¤_NÇåíÕµ3ƒQÆŸ€ J-mÜ„Ët:ßuUÂz:¹íÛÏ/ß�_®ŸA
!u)©YïÒùüôúbNKóÆï~{*²`ÀñG0­º”½4ßßtéëß<VoV1!Ã cB¬Î¦~èJ:ž*Bh“7ÿ
À”–nwwUðøqys³VÕ(ãŸ‚  óðé•/ï¾*O”ÐÞ¾¹ŠïÞ;‡~Çõ›·³}óÕW}ó½U˜¬ŠAÆkäùÄëïý$§—ÿwJÎGÝýà‡ñã»o–Í§o{·T�2~
Åò%¯W�ËË>¡ßFÁñ¤+yšts'öòñ½|¾î	8~B¬ÎUt'þ4/­¡˜ÂÆƒ³œÐ÷«K™^ç×�BPj=áê³Ïíõ×ßNS×Äp÷æîß=>°Y…îí-ß¾^÷»Æ%
+âÖ+�ËãåäW]uI8~RÀéuvopí¿ýð›©[Ýøg«Èø˜(ëéxÞ½ýYÚÿöÞ�×ˆÍvÓáýw¿�~¶Z½J2pü9(”âfÄÐZYÎ�4Á¹"oA’¦“n~ô9N_ýö„a7 V�2~RH«®¦ËIlˆê2Å R¢újÇs±.ˆd!(K:p{÷Æ?|ûîëÛÆGpì`Z¥¦³{s÷#øøÍÁ¾X¯�Aƒ2Í‹l?Y‡ýwßü¶õ×ÝR«�ãŸ‚³¥¨ZÎË¹hÿ¤háÉÇ»«yzø0ëÕneµ�[Þ~ÎïÞwŽoº°¹ï›O/Çþzˆ(E2þ„X¹Ð5”ù�ÚŽ>‘ã
ÓB}Ûä÷G†»ÎgÿD-ç‹~ÚÿòÍñ¹ÙÜìw{áx”’ÛÜ¡Ÿs¸êC‘Å(ã_ÃDYŽ¬?ëËéù›nn×ÉÀñ‡ YòÃg;äoŸtýý~µ¾Úî§�çÆm#…inîwõõáÛ§ö‡W�¬"ã/@A±‰1ÜÜ½ÌÓÃsé;El¼AažOþêûÛôÍ»÷ÇËõ¶C6‚ã—05³ó%lÞ|o¸<=|wÕºØ¾ñíòøÝw\í:_²„ùRÚá{×)}|<ôWkG£TÈø{ (Hù†û{”�ïåºï6»[Û?O­k¶×7óåÝ×b»«Ç5s1ý&â›ÇwçO®VžÅ“±Aa¾äÕæ³M÷òøÁ®Ãfwóº|:…¶ón©�ñ÷AaMIÝíêh/ÏÓ<ôÝâÀñ¦FÓew{½y9~õüÒÜÝ¹„L�Ío¶’^Ð®±p¼…`2±u#)¿Tï† Z(”šs¸ºû|>=¿Û×®ëûUh–ãÃîVŠ9 ¤–¥4ýàËüje�Ö\Ž
ó”›íç«>½{ †mÃEŽ÷ (H5wÝ'»ãéÃÇ'Ù*ÂåTãÍ§7þÝ‡ïÚÍª[Ý8„f0šTÈø}˜VØé�¯>ÿ~÷øë�§þvSK…QÆ¤æE†õ}´üú­ÃýU^Mbã bKÙnc}}y}^vM›MaãO@A­‹JÛÑÊ)/(X¯·e¿¹@®ÚÕz×»Ãå\R×mwyÝ?$·ÙDš“ñg 0ùÿf}ï�¯ï+Ú7—ûIm¼©¨ËQâ›Oìòøñýå“›�oA@l.pÃ­Û_¥n*AŽBjYªï£¯Ëœè›W„ã€]ˆp³Öååñœßî",	lüPˆ„ÔÄÁ0—	¹ºf+x¹¼œD7²ÛV«/¯Çf5t4��wàèQÒÙÝ~Ú]—ý?îÛõýJ¬ ÿ%M®½{ÓÍO¿ÍXÃm×òåñý¦i‡««�}Ø¿;+†–6þ>(°2«¶,§K�÷& Ä–9a·Åü¸ZÊ®‹¬6þ€—ìÖwŸÔæéáÝ„~Þ„n™¿}‡zµÉYŒ¿ !V'Ê¦ï,�O!ª6Þƒ€¤:çn·ò—×çclºY”6þ([`íÐƒ—4Ušk·˜/‡§å)ÝÕf§zz¹äÍÐ‘£"Ë¹i‡9kŠÞõëÛ0=]^q¼òWWœ~û˜|»¾Ù®âòòôAÚ]�J¥�BŒK±n³ióùù4OÛ^Q6þ-@²òæ{?¸-ßýè¯W·»]øöáÛYâjuÝèã‡÷®¯z–ª´ñO@¡0ÙŒÕ®qçç§cí‡ @[MßJZæZõTW  ÚL6�iº0¬}S�ÚøËy®Ýýnç¯>¾kšÝÐˆ�	RÓ´põ½;àëo^á6Ûë7»X¦Çw‰»u„%áø— À²�u»¹‹îy:5«A‹+ÂñÏ@™c^nã}j^_?6~·^†yü#P`6C†vHv)GJÓÀU*ˆZ&„vM9”Cu±¡ÇŸ‚œÜ¬WwžŽû}Ó|ï~øQÆ?µ,qã˜§jÎˆVN©Æ»­Ãéñ1Ï7}Q¥-Ó¢ë·/ï>àn;4¨¤fw)è6o›×çÇç“Þ¬{-Uiãß‚ã’ÏC{÷VåýË‡ÅùnMT× ÀÊŒº@›ç	¾Û­úøúòøP%m7[Óî²Ÿ;v±3¡Ø8€‚Z&Äf0Í'ï¼PØøKPÀƒt­Ïå|ƒs&ã— Àì¢�ë«®¾œ?x„MP3Øø%1›ÎÐ·w»Óáåý±ÿ¬ïŠØøsP(µ.—Ð}º›–‡�ßxÝ´A”ã¿…ÂeJõêvððþ˜ß­¯ Ç/@A]–Å†ëÛÎöÏ{Ãj%‹�Rpw[§ö¼›íX}RÅÒ’ÃêÍÑ>>|x
ëU«©pü]P`˜—s3Ü¼õiy|~ÅýUssW.i®Mï©ãOÀ²äÒöÃ/ËËtFl¯®o»t|yE7Ä^
MÀ¼,iu}Ýéüò.×«uï`Âñ§°’àÝ n)§z'‘2þ9ÌÄåT&W½WxŽB,ç$ÝõgÛ«oßlÛ^‹�€%T	}[Ë¼O¼J•ñÿ€È6}ôržóÌ¦ÙáfXÓT|Ó9)ÎH›Rvñi¾ìÓþ*„..Îtü )ÄÛÛíUzzúÚ6Ý&83pü¯ �E&sºic3Ÿ‡°U*µ’3ÌÚvÕ¯—ôx±Ð„N	ÿ%ÈB�n¥`=ÕK›Å‹èø_Pó¥Ò¯û6—ÓnðQ@ÈøŸA¬&ÐÅU+õr>LÅÅà§,S½ï¼Ø<Ÿ‚¨H4Q@Æ_‚eëyàÅ¦|…8~	Š%WºÍæS)ÓÃyº^i_]qÂ,ÙR6ýõÓþé€íÚ7¤Èœš°YášûÓ”|h£`"Pï1Z½HýµE=~8ÖM«¨âªÈxZ¦´MEç9-®uÑ™ ¬eQï{	ež/0´Á™aµÌÊ0Àå|Æ�ESªŒh¨KU½j¯+æÃóÅûÐ†6)!�1‚RÝ<K¹ÚÜvÍåéÃóaèvë”óá2MØµXÏÓëqYÂf}Û”ýñ8�¡¡1)*2FVfHÓõ]¸”}-®µF"ÿ'L+,¹’ƒFß"$^.‚F§¡2`-‹D×;e�Ò,Z¢Å¤Õ-¢®ƒ[Ê™t^½º*2þh¨V¼iPÚ)/
ßÅ çå\Ô¯â:þ9XQ­æ³ãfµ*u~:½ß‡†£XÍZ�ë`5—\áÕA«ÈøW Y’d‹¾�æóÙKÓlZÍår\È°îÚ²\–sö*.V§È¸…ÂšÁ¶m‚a±É¯A)�q‚‚u..oV›·ºì÷ÏÓ•´)ZM"€QŒ‰Uš¾q~>Kuë~Õ…²LË…½“èè3]�ŒÿITˆHMµºÐ·þu:�ÏQ×!Jv4@Æ¿ a”jI‹ÄaIÓ×vm¨)�¼HÐè E ã¤T«yi¤×P™òBßhÌ¾šT™$ÆMlR>&j"D 
`€�µNÅÜ0.‡ãeo!öæª@ •ñ_ÁÄ\rJÍÕÕ¦.Çw¯¹éúNª€Èø÷ ª	i%)ÚQò¹Z`ô^  j-&Q,fTªª£R0 °²¸¬±ñrÉsvƒvmã–z*s,˜‰˜ÚA!Àb4‡¨dI²4PUQƒ%ÍQ;¯nIU§ÊR¬Â «¤ºhà©ˆ“�,sÊ�B¼Š°V�RÆHVŠ EsŒ­S™‹2Fº
«ÅªsÁÉjƒ O«ICç¦i*hbÄj
Õ9!eüo ÕRÅEo�Yç†¡:XÉ
©H¡A°,â´k�,—Ùt.
MXT�ñO`°
::-y² ��©žsB]˜­j%£@ ¥! ÅÄ¬B¼(tP§¥Ö Þ€	DÆ·  ¦Õj­ï¥Š-E\0ee-•Ä²ˆ+â¡¨F
DÆc0_Ëu½w9ŸÍ<4Õ‘€P0•ÆJõN´”Ì`t dü1(1‚P Åù¶Æ’é�Áh	UE[¨H%ÐÃÂ"ªâÅFPBŠ¯¦!ª'S±êá‚	j­„ ® ÿ#j-Ð««ÌpÚJ“m©‰�ÞfBH	3˜ŒÞ1¡¨„^üRŽ“dçÐ3FqtVk)EÔ…*\�¼)RÆ· 	µ¢Òdô*2úJ@Æ_€ F³
õfO£Xb®p^E|5²¡€ h¡’„�T
Háøw0ùÿÄW+BASE      >
  xÁA  ƒ°Yãx` þµ,¹iàl€À† › ÛÆŒáh¶!7¬+5]¹ÐT0TMe›0XØX›Êh`
£ÂmÊ6aÕŠÆ6¬.·’†Lh�ÉX
SulaÖ€•š®dc©4d¡«p›·’†Ìac£ÉÌ±¡¬ËÚ¶’†LXe+FÖ¶pbÛšSTÙÂ&¬¢mm[‰L°Âm
°fÁiªla«¬Q¶†µŠšc’ÈÕ6Z Mbš#shá$æŒœ�›Áæ’fX#EY3)¢TlshI‘„Pæ*j©�1”@×Tk•³2«œµÖr¹m1Â*™­•´A�kFhÛ¤)“ML
D[6—R °[ÍÕŠµ&¢&”¸¢`¶BWe:YUº@�Ù‚Jê  &BPOS      7  xÁÑmUA D±€PÈÝñÙýðC[”Žý÷ßŸ/ooo_õúõ¾×÷Ÿ�ß{øÑó4“=ÇlÏlõl¦¶{Íìv“=¨ÔÅv¯»J]uRí»9*t·Å®²“ T�ò¤Ð™JaÓCq¤Ûšdk¦l±@#ÃA³ZÆŽls'#f�±�Fc²E›qš«‰˜fm“IÜ1[`“¡a¬ZF`30QC,K„¡15ÒÚ’fÐBÂÊ´ÐÒ
 ˆA Y�†D‹UË�Ü	`îUÁ¢Á rÉš˜™yXH6Ölã”rnÁ::“Ž5ÓfÌXcfÓóhë4€öiÙœÇ�"´Ë­´¨î®Åî^Y«]Îy�i;w˜vOl^ïîÇj‡g±€C·½NØõí“ùCò1€CNF4      MÒ  xÁËnÓ@€á<sìØMš¨WYÍÄ¾ÛŠ8^�·â%Š*�+ÊEŽçxfø>÷~úÉÀùTä|ÌMM.öís¹¹¾¾]î»°_cOo:Zx|­—tÐj�‰ÞÐÑv­>ÐA«w˜è9&z�‰žc¢&ºÅ}…‰.1ÁD¿`¢g˜ègLôqjô#f�^ñ*˜ ÑkMÿÒSm+F£D´f|îÙiÀD…Çíôâ×É×±þU²-C˜`ÿpd±rcLW�hÉ¿o‘ÒÝ‘ùAuµÆ¾_?ÁÆ¥Ð3Jˆ\Ï‰ßPM3þ¦ßß2pÔÀE‘Ž‰"Áál¨Ý)§"Æj“‚ûI
Ì89XÂ8õTŸrçIÔ	
zGZV‰ƒ_~�Ê¹˜4£ÍhF3šÑŒf4£ÍhFwü=O™òTEXT       Îö   xÁÛjÂPÐý)óæ°g&—6�‡“Vr1Ä(ô)hñ±Ø‡Zðï»¦8vÀ§æ8öb¥¹¿ïšJs÷Ý¾RUîÖJ³´ÀiŽ4o.hãÚa}ÞE)ãõ%ôÒ‹251šÉïCÖç]”2^_Â¬$KšÍ°œ§F3fÊ@÷"5IÄhÆL˜‘4´ŸÝŒ¾Þ¼pnóq.¶º]ÿ<|?ncó�X’¹I”–c<¶¼p¢nâ€¾·¯\ºE‘âÒ-†¾ü�ñ5:CLIP       	           i   	  T®ZTR

BASE      >
  xÁA  ƒ°Yãx` þµ,¹iàl€À† › ÛÆŒáh¶!7¬+5]¹ÐT0TMe›0XØX›Êh`
£ÂmÊ6aÕŠÆ6¬.·’†Lh�ÉX
SulaÖ€•š®dc©4d¡«p›·’†Ìac£ÉÌ±¡¬ËÚ¶’†LXe+FÖ¶pbÛšSTÙÂ&¬¢mm[‰L°Âm
°fÁiªla«¬Q¶†µŠšc’ÈÕ6Z Mbš#shá$æŒœ�›Áæ’fX#EY3)¢TlshI‘„Pæ*j©�1”@×Tk•³2«œµÖr¹m1Â*™­•´A�kFhÛ¤)“ML
D[6—R °[ÍÕŠµ&¢&”¸¢`¶BWe:YUº@�Ù‚Jê  &  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  y<AlignableSequences><Sequence name="110_CMV-F_TSS20220509-027-02425-03_C09" ID="0" isTrace="1" sortOrder="0"/><Sequence name="110_CMV-F_TSS20220509-027-02425-03_C09" ID="1" sortOrder="1"/><Sequence name="110_CPPT-F_TSS20220509-027-02425_D03" ID="2" isTrace="1" sortOrder="2"/><Sequence name="110_CPPT-F_TSS20220509-027-02425_D03" ID="3" sortOrder="3"/><Sequence name="110_EF1a-R_TSS20220509-027-02425_G03" ID="4" isTrace="1" sortOrder="4"/><Sequence name="110_EF1a-R_TSS20220509-027-02425_G03" ID="5" sortOrder="5"/><Sequence name="110_enCMV-R_TSS20220509-027-02425-04_G12" ID="6" isTrace="1" sortOrder="6"/><Sequence name="110_enCMV-R_TSS20220509-027-02425-04_G12" ID="7" sortOrder="7"/><Sequence name="111_CPPT-F_TSS20220509-027-02425_E03" ID="8" isTrace="1" use="0" sortOrder="8"/><Sequence name="111_CPPT-F_TSS20220509-027-02425_E03" ID="9" use="0" sortOrder="9"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ,2<?xml version="1.0"?><Features nextValidID="24"><Feature recentID="23" name="Mapk14-m" directionality="1" translationMW="41488.51" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3682" maxFusedRunOn="3682"><Segment range="2528-3607" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="22" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2238-2441" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1934-2237" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8891" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8100-8891" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8892-8960" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="5659" maxFusedRunOn="5659"><Segment range="4274-4936" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5060-5659" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7341-7929" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5660-6247" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3947-4215" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6321-6554" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3723-3934" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6766-6901" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6626-6747" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8961-9065" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5056" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5659" maxFusedRunOn="5659" detectionMode="exactProteinMatch"><Segment range="5006-5059" color="#cc99b2" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="6987-6993" color="#ffffff" type="standard"/><Segment range="6994-7011" color="#ffffff" type="standard"/><Segment name="-35" range="7012-7017" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7032-7053" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6963-6979" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6130" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5747" maxFusedRunOn="5747" visible="0" detectionMode="exactProteinMatch"><Segment range="6131-6142" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3679" consecutiveTranslationNumbering="1" maxRunOn="3682" maxFusedRunOn="3682" detectionMode="exactProteinMatch"><Segment range="3614-3679" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
  
Q<?xml version="1.0"?><Primers nextValidID="4"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="R2" sequence="TGGTCTTTGTAGTCggatccGGACTCCATTTCTTCTTGGTC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="3586-3626" boundStrand="1" annealedBases="TGGTCTTTGTAGTCggatccGGACTCCATTTCTTCTTGGTC" meltingTemperature="69"><Component hybridizedRange="3586-3626" bases="TGGTCTTTGTAGTCggatccGGACTCCATTTCTTCTTGGTC"/></BindingSite><BindingSite simplified="1" location="3586-3626" boundStrand="1" annealedBases="TGGTCTTTGTAGTCggatccGGACTCCATTTCTTCTTGGTC" meltingTemperature="69"><Component hybridizedRange="3586-3626" bases="TGGTCTTTGTAGTCggatccGGACTCCATTTCTTCTTGGTC"/></BindingSite></Primer><Primer recentID="1" name="F2" sequence="caccATGTCGCAGGAGAGGCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="2523-2543" boundStrand="0" annealedBases="caccATGTCGCAGGAGAGGCC" meltingTemperature="63"><Component hybridizedRange="2523-2543" bases="caccATGTCGCAGGAGAGGCC"/></BindingSite><BindingSite simplified="1" location="2523-2543" boundStrand="0" annealedBases="caccATGTCGCAGGAGAGGCC" meltingTemperature="63"><Component hybridizedRange="2523-2543" bases="caccATGTCGCAGGAGAGGCC"/></BindingSite></Primer><Primer recentID="2" name="R1" sequence="TCCTGCGACATggtggctaccgtcgactgcagaat" description="&lt;html&gt;&lt;body&gt;&#10;&#10;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="2503-2537" boundStrand="1" annealedBases="TCCTGCGACATggtggctaccgtcgactgcagaat" meltingTemperature="72"><Component hybridizedRange="2503-2537" bases="TCCTGCGACATggtggctaccgtcgactgcagaat"/></BindingSite><BindingSite simplified="1" location="2503-2537" boundStrand="1" annealedBases="TCCTGCGACATggtggctaccgtcgactgcagaat" meltingTemperature="72"><Component hybridizedRange="2503-2537" bases="TCCTGCGACATggtggctaccgtcgactgcagaat"/></BindingSite></Primer><Primer recentID="3" name="F1" sequence="caaaaattcaaaattttatcgatactagtcgttacataacttacggt" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="1904-1950" boundStrand="0" annealedBases="caaaaattcaaaattttatcgatactagtcgttacataacttacggt" meltingTemperature="61"><Component hybridizedRange="1904-1950" bases="caaaaattcaaaattttatcgatactagtcgttacataacttacggt"/></BindingSite><BindingSite simplified="1" location="1904-1950" boundStrand="0" annealedBases="caaaaattcaaaattttatcgatactagtcgttacataacttacggt" meltingTemperature="61"><Component hybridizedRange="1904-1950" bases="caaaaattcaaaattttatcgatactagtcgttacataacttacggt"/></BindingSite></Primer></Primers>
  ?<Notes>
<UUID>83ad4f97-e9d0-47ac-ad18-1650079de2ce</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="5:31:58">2022.5.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1932" colors="black"/><ColorRange range="1933..2520" colors="magenta"/><ColorRange range="3607..9563" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1932" colors="black"/><ColorRange range="1933..2520" colors="magenta"/><ColorRange range="3607..9563" colors="black"/></BottomStrand></StrandColors>  9ö     	”  %f        %fs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›ä²�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M‚¤…òÑ¼äÎ|Ñ»µ:Å®4±Â|Àü÷Ø³AýÊçÃA8]GÛ€B?ô_‹ü ;>`ì"#Ž¨gTp² Ò”S‹ò­/m­ÏUçÄJ2ã…7a]ÅX†‚â�ˆ­ßÍBÞµ‡"~nØ Áø]vÈR=áñÇÜ­*í¹ôo¼@áI™ÚÃ‡e­Ð•?M~N!qGˆNÔk�ªƒ°Ýá†‡CœƒŸB	ñ?Ñc… cy—ÑÒjÈ6Ø8N(|\¢¯‚t}š_N´Ñ–2áÀÿã¦í¥ÐcÔöÔW�­.àýñF¬Õ‰© �[þ,~xF;*�íDtÓõ;£6>zŽÒ}Çøa„ø£‡úaô¾¡S@~»da Q>˜aKm:ˆ÷ßúQE`KÁ¼yÕaÂeFØvÇ�A‡u$ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘Ï}�DÃãóØ±#Í·Ã…Ã JÄà€Ã@ßýMÍ‡×Q…}PÏáúÓþ~8OrpëŸzÃ~Óqþ¾7=µ×9ß]üÛIÄ0Èãr­9óœCÃÌ†Ãµ 7Ã¯ñL†ë|uo4×=òß�ÿ`1—#‚N³ó~´øÌpÃžtë �ÓÝ�ëQ3ÛßôÛãEÀö+>¼ó A8Ý5ß€Û IôÜúÔöÏ¬ôoÌí,½k� pß<Ã½ðnÌ@Ñ.¹v0‡ Aü?˜|IÔýÂ3ì÷órÿ@òs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øV×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           	è  !  &  i  r  t  %e  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ,C<?xml version="1.0"?><Features recycledIDs="23" nextValidID="25"><Feature recentID="22" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2238-2441" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1934-2237" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Mapk14-m" directionality="1" translationMW="41488.51" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3692" maxFusedRunOn="3692"><Segment range="2538-3617" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="21" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8901" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8110-8901" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8902-8970" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="20" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="5669" maxFusedRunOn="5669"><Segment range="4284-4946" color="#05fd14" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5070-5669" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7351-7939" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5670-6257" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3957-4225" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6331-6564" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3733-3944" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6776-6911" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6636-6757" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8971-9075" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5066" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5669" maxFusedRunOn="5669" detectionMode="exactProteinMatch"><Segment range="5016-5069" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="6997-7003" color="#ffffff" type="standard"/><Segment range="7004-7021" color="#ffffff" type="standard"/><Segment name="-35" range="7022-7027" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7042-7063" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6973-6989" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6140" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5757" maxFusedRunOn="5757" visible="0" detectionMode="exactProteinMatch"><Segment range="6141-6152" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="0" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3689" consecutiveTranslationNumbering="1" maxRunOn="3692" maxFusedRunOn="3692" detectionMode="exactProteinMatch"><Segment range="3624-3689" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>76ed5771-07cd-4838-a046-f081a7ce3822</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="5:34:1">2022.4.28</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="0..1932" colors="black"/><ColorRange range="3617..9573" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1932" colors="black"/><ColorRange range="3617..9573" colors="black"/></BottomStrand></StrandColors>  ;G     	¨  %¸        %¸s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›ä‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔ¼ÿæ‡-aÂVÏƒi�Òv§êùè4�¹É¤¶Îiöc
 ÒwÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²YÏò‡5`0�Èœ ¹™M²¤…òÑj‰gÞd<¬±ào	ñn<ó=‹4Ü®|4…Ô}¸#ñqŸEø¿Â°3æÂ"8ê†uG Û")E8±*ÒöÚÜõP~|D£.8SvÜUˆh.(ŠÝüÔ-àAkXr'à‡öí€…×l…#ÑN}ÊÒ®ÛŸFûÄ™�¬8vZÝùSô×äâx„íF¸ 8;Þat9È9ô Ÿý¶8Z7™} f ¼€ãmƒ„â‡ÁEÊ*ø'GÙ¥ôëMc.ßþ:nÚ]=OaEyÚÒîÑ�azÍXššõ¿àâÇç�c²¨Ñ”A·M?Sº3cç¨í'Ü†OŠ8¦Kê4ë¶Fáù†¶Ó¨�}ÿ¡õV¼Ç�Qö!¦Tm‡lyÔq‡RL<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø1ÄL>?=�<Û|7ø\2¬N0DÿÔÐ<Ø}uQ7Õþ­?çã„÷!€ç¹÷¬7çý0çëãsÛ]pÃ�õßÍ±œAÃŽ7!:ÓŸ9Ä<<Èl1ëP‚|:ÿtÈn·ÇQ¶óMsß Møßör8 4ë?7ëOŒÇ9çN²=ØÞµ=½ÿM¾4\ ÿb³ëÏ2�Ó]ñ8²ŸMÏ­GÿlúÏFüÎÒËÖ¸òóÁü;ßìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           Œ  s  x  »  Ä  Æ  %·  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  -<?xml version="1.0"?><Features nextValidID="25"><Feature recentID="24" name="Mapk14-m" directionality="1" translationMW="41488.51" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3774" maxFusedRunOn="3774"><Segment range="2620-3699" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="23" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1934-2313" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2314-2517" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2543-2561" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8983" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8192-8983" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8984-9052" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="20" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="5751" maxFusedRunOn="5751"><Segment range="4366-5028" color="#05fd14" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5152-5751" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7433-8021" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5752-6339" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4039-4307" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6413-6646" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3815-4026" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6858-6993" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6718-6839" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9053-9157" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5148" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5751" maxFusedRunOn="5751" detectionMode="exactProteinMatch"><Segment range="5098-5151" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7079-7085" color="#ffffff" type="standard"/><Segment range="7086-7103" color="#ffffff" type="standard"/><Segment name="-35" range="7104-7109" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7124-7145" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7055-7071" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6222" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5839" maxFusedRunOn="5839" visible="0" detectionMode="exactProteinMatch"><Segment range="6223-6234" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="0" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3771" consecutiveTranslationNumbering="1" maxRunOn="3774" maxFusedRunOn="3774" detectionMode="exactProteinMatch"><Segment range="3706-3771" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>76ed5771-07cd-4838-a046-f081a7ce3822</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="5:33:41">2022.4.28</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="0..1932" colors="black"/><ColorRange range="3699..9655" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1932" colors="black"/><ColorRange range="3699..9655" colors="black"/></BottomStrand></StrandColors>  5µ     `   U         Us"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘9>Åì²¤[ñçT}‡i•aÛuaÔ“1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎG=öLq�Ï`FÄ�6ßþ�+‚õ46]FMõC?‡ëOùøá=È`9Ã®}ëùÿL9Ä_úøÜö×\0ç}wólE'pÃ#�ÈN´çÎq2zÔ €ß¿Ä2­ñÔm¼Ó\÷È~7ý€Æ\Ž:ÏÍúÓã1ÃyÓ¬‚Ov7­DÏoÓo� ?Ø¬úóÌ�ãt×|Nl�'ÓsëQÿÛ>³Ñ¿3´²õ®<�Ã|ð÷Á»1DºåØÂ�[ðþañ'S÷Ï³ßÌqËýÉÍþÏ<ÊÏÏs=ß,oÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            •  —  ñ  	   	
  	  	  	X  	a  	c   T  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  )“<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="21" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7604" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6813-7604" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7605-7673" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="20" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4372" maxFusedRunOn="4372"><Segment range="2987-3649" color="#05fd14" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3773-4372" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6054-6642" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4373-4960" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2660-2928" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5034-5267" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2436-2647" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5479-5614" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5339-5460" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7674-7778" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3769" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4372" maxFusedRunOn="4372" detectionMode="exactProteinMatch"><Segment range="3719-3772" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5700-5706" color="#ffffff" type="standard"/><Segment range="5707-5724" color="#ffffff" type="standard"/><Segment name="-35" range="5725-5730" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5745-5766" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5676-5692" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4843" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4460" maxFusedRunOn="4460" visible="0" detectionMode="exactProteinMatch"><Segment range="4844-4855" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="0" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2392" consecutiveTranslationNumbering="1" maxRunOn="2395" maxFusedRunOn="2395" detectionMode="exactProteinMatch"><Segment range="2327-2392" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>76ed5771-07cd-4838-a046-f081a7ce3822</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="5:28:48">2022.4.28</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..8276" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8276" colors="black"/></BottomStrand></StrandColors>  3q     R            s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘9>Åì²¤[þ1›Ó0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`DÇ0øüölHómðßápÈ±8 0Á7ÿS@óaõÔaDßT3ø~´ÿŸŽÜ†œ:çÞ°ßŸôÃœEÿ¯�ÏmuÃw×6ÄRq28Ü„ëN|çðó!°Ç­BðëüAÓ!ºßFÛÍ5Ï|�7ãØeÈà€Ó¬üß­>30ç�:È t÷czÔLö÷ý6øÑpýŠÏ¯<ÈN7MwÄà6È}7>µý³ë=ó;K/ZãÈ7Ïðï|³4AK®]Œ!ÈE¿æu?pŒû=üÇ¿Ð<œßìóÌ¬ñçü÷3ÝòÆð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>µû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           •  —  ñ  	   	
  	  	  	$  	+  	-     !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ']<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4789" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4406" maxFusedRunOn="4406" visible="0" detectionMode="exactProteinMatch"><Segment range="4790-4801" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5622-5638" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5691-5712" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5646-5652" color="#ffffff" type="standard"/><Segment range="5653-5670" color="#ffffff" type="standard"/><Segment name="-35" range="5671-5676" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3715" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4318" maxFusedRunOn="4318" detectionMode="exactProteinMatch"><Segment range="3665-3718" color="#cc99b2" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7620-7724" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5285-5406" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5425-5560" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2382-2593" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4980-5213" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2606-2874" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4319-4906" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6000-6588" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3719-4318" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4318" maxFusedRunOn="4318"><Segment range="2933-3595" color="#05fd14" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7550" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6759-7550" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7551-7619" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>b64490df-681d-4c2f-a3de-086749b86fba</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:26:36">2022.3.24</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..8222" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8222" colors="black"/></BottomStrand></StrandColors>  <ý7zXZ  æÖ´F !   t/å£äû] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnãýJ„<Ú§dŸÛgð’~(_XÌ2Ò�·¦&p*ú¢–œú¢Ös*âŽÙã
ÿì+�Š3–
¡ÍrÿÞE8k@
vœþ6ã³‚�ù®�@vz-ÂA îËn�ºß——a²¼‰,¿!v²±¶ÐÁ§Î‘hÑØ1%%RÂeÏ­ø×Ùwn»Ò¸Ì2£ ?ÒòòÅ-ûõ™#µ¶æót’„KûEô·ÙóÅvr¨ßªêGÊL�ày�Maž¬sIl)¦a?·¨¼ùå¹"õîžÐ¯£··SI:ÇÚÄ©]�R4ä`°Ùí	�Å
~À!i8AS©SÔ°Á1Á_IßÀbš>mÃdÐBâÑÄg8«^E6Ée[«rnŸ&Ž%WYž:E á‡B5eîº‰¸‰:‰Ž×0ÝÛYO€¿*¦,œ
2*�6ü®Ú  ªzLÜÈÿÅÍ¸ƒ¯ûî3zhAŽ6 é ØM®fíÓ	—‚°óà5ÎCc,6è'”T×Vã£Ùá$¦|e2Ø”	}œ³ŽD3^† à6Sû}¿¬øÃÜ‹š¦[7IÇ¿Ö¤/,[2îïf`/ž×º»gª>+p3Z9õ�îD�d33¡¢diJü¨ô�‰ì/ƒ4c*Eyzç:ÉÞOÔõ^W/”uÆ0û°]n _ý}çÔÏ¡×²�,ÞaHþlˆlô‹îÒœªÕ|Ÿ
½?Ì¤4Ðèe‹Í³¬Ox]ãÓA˜Ž0ÙÚÏ¶­í{‹¹ú ¢5à²Zû.øMèö’Æ¹”O(K¿
\'Îs4ÖÂä\]ô&åÖ?ð�¯ýˆ
¿Ç.ÕÜÉ¡¤©Å:_¥4'åk¼Øf½ízÌ§Ë8@	½_I’»D¨çÀUi{±Õ~†ž²±w„�›33›�Žn•ž„;§¼|ØëÖQø ÑsÇCRÉ›óÉÍ ;Ð<'b=Q-£°‡g-Ö€ºÆ>—# ”�–wÆÓ°’üæ¥À#_ý}·k‹Pªn”�à¯ÿ@k=¶e—9Ôp¾á"osVE…%—’¼UìP ÇÕ'Öy8>¡q4öZ2²}nk„Ø’8¬
ó.[¥úü™À³D}âîÇ@ŒÌÌÊü²Ûqœ?I“�:Õ.1ï¨ÁáGý9õr}dõ½Þì¤ÚŽdì�QvÂ–cxläåÈ&ä…Õ½çO÷|ïN•&ÙC~¦Ûê„ù‚öCùŸÖ(1Îá«|ƒ ÔbÚs@†ƒ�ºµš†°…oY¹>îQæÁieÛ.•uûÕ6‡SbI‡ŒÔó¸ã¦ý<ãîA¤a.<fKLEä`+ÔÞ ƒÄÏŽ–…ÿ?ÚA©ü5Ë$*¡3Ž9ŸVaªÙy_Á–ãµ¡ÑÌó*ahVæüðO�™­Y3� ß†Y­E:¸Õ3ªÈL!PåC��Š8ÀÎÚÊî©¿˜¸ÂÒ[0Ðb–æ®¨Âë!àØ,k«oô|Ãò}UW§¬CÙÜˆ¯l
'å£¸‹ñ‚zÀaxq_+ú®bZ˜•ä§,‚»@~>pzEÉ\CÑ”¿ì’¾J´~qìÙøÔ„ù�/'$>
Š]8Ê0ú7ë)Î]Ï'7^ƒz5pw<®o—'x¨Ë¢éÒoi7GåI·��~‚î
¿ª~æ½ÇâÁÙu­lOs…ìFü¾Á-œEZÓ¤œ¡/Ö( u×š¨ÛaÞ¼ ë}ûîªâëŽËð`ØÆ¤�¦õªÇÖ@“(S�!Y«I#(Mª«ù¡p�ÝÉ=÷"¢“q¢ÌE´>ßÝÙNý¬É¶|ø'èt8V»+ÉüÎ¼ÉtaÈkit)±Z@¨ ‡dçqçØ’,ž>ÿ÷û“Þ&LËÄôr�êj1â^ðªô›£õtëÊO1—üï=ø‡ae]ØüJŒ®4H)ëw8¦Í1Eæhb¨öšú§ì"„dìuTy'G‚XƒÃìXÀqƒèóá&Í×Ž	Üµõ|–Â¸êšN‘…/	�Ì;È\ñ†ç<¸`6P¸~ü•›�ï…Ò�Ã“�Ó›æ1ÆÅž­R0øNÔ’¬P‡Ñ½ÔU±H£MðV‰‘GÐ	CrÖ~‰mÖØ\›Ê2�} –˜kñêEcâsUL¶¿°Œ×—Ã1ÿ¢ˆZðuú–Å°õY2(uAnR»~*a¹«æÉÍè L-D¨†'¢3‰{¢³-‚ÿÙyÉ ¸žK�¡!2R
8e	Ãà‰ày3ÿå¦€5•-J;ZŒ3e\µèèým¾z@ÓMÈ%ä~
Ÿ²YÍØqªYBîþ8q]óËnoòS÷ÜEÈÛÚLÐšû&L>3¦îØoA:&ìÅPê€»åBà»AÉÿ}m¯áþ$ù	ò°8ñˆÉ–Žžh.+e[6�gvP+Îþ!‰‹0·	^ÍþÇë=æšêo÷–ËZ:¥ø‚˜‘>MØ‰Ñèäî€Eù�Bî[•[N "éðñô”TîF"oQüW·•Xeíƒ^ˆýŠ‰Q7äJoOi»å~™hžI�õ£
D#jÁ†¸t.ÔMr¡ÊópÇƒ{-Ë“Í3ÎƒXýÄèÓ…ãý�îœó=‡U|[¥JLÏ]Ý&XœðºWî¤mùŸk­‰~/üs=8Â´[Ä5Gy»Ô5ÙñJ’uö92H–H,Ê.ï’¸8ömû^Ô¶�Õô:K¹ �"S®¯·H{âÿ¥#—t÷ë¸<©Áî·7ð·]£Ž«âüë‰·FRÆ¨£;uq|Ù<"Ûr‹pjWŒ�´��5ƒÉq¢y™}hðô©=�$ˆçôOCËõ´ˆ•…ôj5l†ï©j!‰»Ëåií@‹ºÔÙvK%w‚%&3§}ðÝE�9�”zfaHd¨5ÄÓh¡(®±ÐÜ‘H˜ªßÅ¿d$â ›PAf­bÛa„þíïÐ¢RMû@Qp–®nclñäY:ê‡$&+û®hH Yùðr
€¯•ñÅ×S`n˜ƒ):ÿÝÀ–^X]�öx»Ð?ÙÐÕìûT°è4äVoýÍÛ‰â¨F
ˆœû’{XÊ4€óœWH¸§Sz¯á_ûM­¡”&àš5²(ûm%¥¤˜mÁ0.õ‘:SÍFhë%=ù¤YŒÅw.ó(:¯¬ªcìÙX¹µ‡%'ùî†Ü+éÈèˆÖä�pSEQ]ù—J�\ÄŸijX‘Q=M,@¿^pÁ~»Š"a÷úŠNtÏm(K^JNž^š9Ë•(Ý.3ñ¡¤æ&p¶ùQ~« É4rùAèlX«96GžÀ0ý)ñ@MWÁ|ªð™�>>ÇF†‘…þñ:{F*œ:=haE`zfÂ÷v³#“m)š©�A³ÂÕÏ7ÿ¢u<Ú&¥”G[9É©"yˆ*_ñpÐ&\Í!‰)É†1�ý¢äjpS›ZÂsú&‚—€ç—½ÔbNŸ@½£|£oz	ÈNÜ0/ùqY’ÏÅÍL’*p%B¦L|V(NZøþÏŠŸ5—0ÜR	+9‰6z‡Oö;Ó…wÏ¹$õÒ«:J!“ùž5oQÞAÛqá\GÍ…©�;‰ícØÁ‡{•fuØŸ¯J@
K:FþûÂ ®f=H6ÆE®d-Rá‰B-�šþ]Œ°$]Y+~ït›¤
5Eá!MÖÏÒ_Ô³Œ�RÂnÏËúø¶&àÑA P·~{6#örDð=ç\W¾õ?ì÷7Y¼�Kþ –�¤
O
³«·ô".ÕFÂ)æáb%FKøŸ¿z/ó½*�ØËwÊOÛ†—^’\‚�,ç)u.]äÃL„yfÕïŒnÔšTŽ�‡(¯}Òh.‚°hcÝ†æ �·—Ã=H(³¤0®"g0m> ÎhŸNÊÿ¼OWÙ–!è4¿ñ«q’óþH!Lh:Ä¹ŠõÕ"›|¤[ËtwÑýÑåÆ Dé-c›( `¸èñúëÝ‰_2“m#Ž|Ð>SŒG‡>WÓÿKò@ 
{½æ‡ñ”—yc˜êˆ‡Hê÷­½¶Ü?îŸ(ž@šòŸ—»‰,RB#ÇÒQ�ˆöÃe“¬�6\š†b¨|"Æü§Ó2‡Õ +H e»ç¤D¢‰.>äÓµž—Ð)…ƒBq]A6„6ÛgÌŒ ïüRö0šôÆëÅÙ¥�b€˜:¬eõ
vþÁ< Wå<Ò¡ã!˜û¹Ü†î¨AˆL¤Xë±Ö+€Ïy`ãtõ¬JŒŠ°iŠ¼'
½T\¨ômæ…_¯QÏ}Â°¦Y9ÑÁøGg`µÅÃX=æƒÈ /5Ù¬>$Ð}VÜö	ñöd‹/Wë€M!èßú¬6ß©v˜6ŠdŒök‰”È}—(”µ¿\(Ñ”G½N^ëÚWÓf2þ)�Ï½fŽ8ô 
1÷+ÉKò0A~®ß2èƒÜ»Ë�H™\"ÇÿµkÁ›WÁ9Q µvæÝ+É­»m”zŠíÐÆfOEë¡¦s2¨so»æ±*�ê>qhÝ‰„ì‘½ùÙÏrøû,´qŠ=>^Òá‡�š–Ø
ÓÍj¹~ªä]ñlÉÊdL™ì�ø}kz‚Ñ±ß½#ñâÀÿÙï’–§7²PÁ+Üˆj2ÐltWgª¶Z9Í¦` dóþ¦	I¢"r0C»*ù–µÔ„ÙD–Ô’”F‰ íÑžuÃxr"NmöJŠï�x!ˆnôs&‚p`ýr+öOÝJJ¢™@MiZ1Îÿðí¹s‰­Ð¿\6ËÈ‹Œ°=j&c¢/Mx£ÿ„ÊÜ^™ß™ó·ð“ÄéBTe°qC’{§÷Ñ1lu÷'±ìà“š gô
ž,rl”äÄ�£“¦BÞï¿}˜üù¡¬y‹®‡CóŸF @ž–´¼>Ü&Ö?Hé/ò7ƒ‘ADú¾Ä<#[XÛ“ÂäfÃ‰rÃŸ ¢×j¹þ}õnŽªZ‡ätüÉGERÇ�²ø5 ¡‚‡ÑÍóY¼“­rb@¿[ñù÷SÆF�ëçzˆs(4œãXÆ'´<ƒÚÈM3†e¨ô�ìü\2€\•ÒŒfôóX ág¤óªÒù”¸JÌ£úÄå@³TkÃ¡Òƒ>½þòÎ•ÚìèŽ®ò7ÕŒ@Áù¡ÀEÊÿÕâÚé×áÈÞ©j0 �.·Â<'Â+�†3.jþáÚÊ¢4ñé¦àE’ý*Z˜zI”Óˆç_n|®ç?ådj¬‹µqüÄmÝ‚Ò)epb:o4RkœR—×7šûÏnE~Ö¶v°Ìy—6CœÓ¾§‹Ý=�n}¨%'y­»yœ¡ü¡v»’A‘ ^vùS‘ˆULé.ÌA~È¯¯¬†¦• nÀ·äº½g=ðÊeQ¸k.E\d}žf|ÉÔ\ø3âÀÃ	Ü%É†h¿Æi!,:oSÄ¯—9hü™&È‘ƒ·q7þÀù—j\Héþ 
Ö—†•!ˆ(o_Ê&Ði‹“.šµ}åÍÐ8¹‚µ‘?‰wüúiöø”:§F¦ �½H?ÿHZ3�9=éÏUtŠàzö¼‡€’XüHü³ø»GÛ(ze]aB~Y^�Ø Ê(Ÿ^÷˜ÆV7Ú%\ÚÖ�è‘x2G:ü‡ˆíåÅ™€qàv¿QçmðTùÜR
XAb^šÃË½I8¸m¨›Ë_Ûç,³ºŠXì×çtåÄ©@Œ:)ôê�‹ððž_ýÖ“Î�ØjéBÃ’˜&‚°AÃxÞ'ÑCÊvXŸOdöÉöÚ;ß
B)¦Ã{
šºZ[Ì//Œ¦õØjh7nûÒÝµàÁ¶Æçíè#Ñ=‡¿B¼º^1f1[{IŸ#Ÿ–yÜ—&­Ô®�¹$½,8|hä‰£ÁÎHy|\r8¬(*pkJ§�+ˆ‰l¥3pºYª<|¢ÏW„)²Ë+¼»žiÀ~qßß1VøÛâLÐõZo}JÀgØ;ŸŒ‚ÉÃ×Gò×îFI¸� ÓÞ_îˆ³~aÄuÏ2ŸòRE« ˆ•ÞGx5�Ø¹`ÔÀ$”Ú’C“ã3Æ¥½]qÖ o¥ŠÕ Ò×,ðú˜e;~6ÉÐd¹+\ ¼Ù+-:¦}¡Ù=8=ýÜ0>†¦«QÏÎZï­b€/û˜” õÃ®Œ[Dõæþ«5žB¤yŠÏDì7::y‰nõ-ùÛ9¾LyD~[-S5´¾®ÿÍJ9èé´lËÚi)=mP	ŽÜÊÊC_þµ,Às6/6ù¿«ùFï¹V›Çr³Øo¤|<¾_�Îï·­¾5þƒîUŒëtÛÒsF¿bû|ù(ˆF“Ê™E¸XûýƒÄs‹‹»=:La-(Rìçvïã½Roƒ]ÄO‚†,£p» Lå‚‘…¡á¬2™Ï*ÇKô@âF *F ?o/^¥ùµaKl
1öØ]#þ²7,»ôägñˆºÊØ`Æ“°“oýÍTilÍèåaAáš·=Ä»¸ÃxÌ	ü¾û _ÿÔí©·M<&ßëë!¤–Êƒ£½V„ÑKYUù|/> ær½÷›IuÇAâÛ¹~ÉzÅ¥˜
×iÇ;²‹b5ÿÛìK*»Ô). Š­­{«xx•Ž¿/#ãÒ9ø¼IQ¹ç)@½7¥dY:úŽ¹G¾¶ŽƒjþI9èAÉ6½�ßëg\N§‡„ø%�'1Ãh‚ð�ÉvŸ”Â�Š¸uëøxlh�_ÿIaºu	*ò­ºÛMöM ö2¯ËÊç.ã<U´$%MBVa}wšÉÑúZñj“€vtí)KxÌ~u�W“³ÉFB@àÚÇM´+šêþ|…8‘ÑD¤j?ÌŽû†¡ÀC ºwg|.YZ�LÐF…¬E_‡Ò¬µÝ5èEpÔî=È’†Âb±êÔ:F—jWP©¬zV-˜³o©#ª‰E5yÇÄÉÂàÛq(ðb™;"€€ÐÙ» ±¥B@©°Û€+EèœóŒW¼7ÌÍºý³.`+ÒîU®&t¸ŸÓƒò·ólIb?µ?@3ÖñË†$8Ì\,—˜‹ ¯²ù…‡*&‰ôr^ÉSpâ\óŒ…´¶(óŠpJ6ÐøþSZ—+WÐ˜ÿ¨¤¯Ý}f†²~O®A9,žhÎ·Üœ©Aî*¨Nû6¢ºÔKçûºÞ<zŽècN?Vv^4ø™.+”“Ïec�Z	h@ö:ì³;y1ýöARÎuZ›ûXmÙ¥ôoØ©cMcÓ±1èúöVº–Í
•G:Ø,Î�gTJÕÚ°"þªm`¢lù·9x (Ð-á: ÐšXÜü“Ë¥a?ÿ05¸T#c;#|ìw5¨{Íš¡í˜\tŠn_›»½N<œ²„X‚%Ù™AÇ­M´VŒÜ-žÌ²l{»E8š¡1�=à‘DP.ºM\Á…�¶Å$÷GˆWÃ›,¡mqg¾.•)©Éi
\ì\ÿ¼^5)Z’òh3¼�D'÷ ß?_§Aªý")`â…  f?Š¿™µ4ÊXì®�oy½Ø:h
{V]¸??é}$¢(¿ŒÅ°k¯MFÁîÿ)6O·M[Çµå‚žë¢œVãŠ£&¬uvl‚Àà]ÕÜ¼°rßçS}p}Ä“E´öû²¨œ(Òk5;Ïæ¼;Êâ{Ôk�ÎÞÆA?o“Þ€Fë²ÆIPâÎÞ¡ÍÂÚ}¿_Ãªru8[sATÌr	¤ä³±Y€�¯©‡U¢ÐÆÍ°…X/ï,@µIdƒ^y°¦²;~8‹¤j‡(+É½­Œ"EL#(ÞÂŒ>îÕŽ ý– a‰5ÂÁ~ŒßtÜµDB]˜ùL¢³LBÑ›§²2±ÑAl˜
;ÌlÚî�ÓÎ…m¡IÑ=Û²º·¬UWÄOÝOSüðÝ¶QtC……å}Ô“�'W”¬³‹
qvYZÕ^ïË§UX@œ^SˆqØÞÎ’o¿ùnÐôzðE·GÜ?®I~so{'Õ‘“½}ÖškwÛDz]uÅÆ¯Žá–El×±ÞLçjxŸVÉX€w�V‰VAûóŠ5ÄëfèüÉß$²#Í[_6$Î=‘B—5žú…¾‡%o’FÐc Ø��NÈñmˆW6M}‡#Úõ”€ì±Ÿ‚ÔÚüy‹Œ�,&ss oe+Ý3gº<òtkËmtôßqœ½vü6¿#×Ø/4Øu’¨"ËÈª†î c¢,Üiõ¶Ž%;wË×}Mwibüá¦+¹Í­±RÉòqDàEÆ?’Eè±½~oÀdy¯É†‡t`hªí±Ð­œªIæ÷°jå%òö¥ëàu”ùqÕhIÆrsÈ<B:šaàóv€c<(»l!\Ü Å¸£[$�ú4ºl–Œ|ñÉv—›óbs®¬¡| ‚�³âVÓaM	œø…!–7cYÈØöÒ\Í‚Ä, ûX¥Œo®ý`g‹Ð§MNn´ˆaüÜ£¦Äï©S”ƒ6ºšÆT†Ký‰�'wÈ ™4–Á]ðyÚ1Ò¶Û1žq6—{u,²9à¾a÷^—8DèøŽ„Ít«à“uaÒ^¥KÂÃcÌÛvìüi›*°Tá„ºVr(Œ|ÝýÈéiO9©Á±÷Ëÿ”Ý(��	IÍf™bÏü0ë¼�½{VX31yœÐ¹ÄK[©&=ÑeŠÇRåœõ¨Ä(Í,à¾<Ü¤ðt.XÒêGO¨âªýp~žÝ5Ñßa‘‰ËŒÏHÌî°"ƒ +^*œ�þ4–Ø0ÁÉÕjÕÛ«R‡î"u©&×þ×º+¸ß"œÞ¡#¯V6yÇß'Ë¯#%UÂðFA3bÒ™0ZìoØé¾HÃaþã ¶E,
éY©RÈ±’û¸ÞÍøó? ”ElìIý§.­$ƒå_Ð^àÑÇÄŠæ\� ã„k+¯š˜[ êûÑÜ4¿Y
ªJ™s
Ã@ƒ]Øœƒ9Ú)Ž_SaÜ¨2~õ'’s›Ö)úPn�.‡éï×�n`;XEÆW°ßÖXïX¢+P…ßŒì“Á‹Ña«·ª×jÑŒA.,ŸÀÒz*)2–}Zs4Áû›-ûh”Z°Ê®ÖÁ@ŽX‚�Ù(½".®±PõÞ;�8o²„C`ÃzKFÇN1)ãH³r˜/ÿ+¡µW ó.éÓ‘Ÿ4ìMqJwéß”GÈ}.â�Gž	¶„ß¬Au²K¶.Üz$#z¯Á”�ÖŒ2ÿø»|'L_sŽO†ÀÑÉ¯ÙVò˜ŸÓp(PXU¡Dƒ	f/Íý˜œDÞ~•Î±¤œ¡§@òëåç.MÝ<•‹ÎÛ_àÊ‚Äé5L½
ªóæ²7íÐÙ—Å7&    ¿`º¡ç<‘i —8†¢ Ùsk
±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  'À<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3603" maxFusedRunOn="3603"><Segment range="2860-2874" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature><Feature recentID="1" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3603" maxFusedRunOn="3603"><Segment range="2875-2889" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature><Feature recentID="2" name="MAP1LC3A" directionality="1" translationMW="14272.49" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3603" maxFusedRunOn="3603"><Segment range="2497-2859" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;MAP1LC3A&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Atg8 family member found on autophagosomes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human LC3 protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF"/></Q></Feature><Feature recentID="3" name="TagBFP" directionality="1" translationMW="26282.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2902-3603" color="#3366ff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric blue fluorescent protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSELIKENMHMKLYMEGTVDNHHFKCTSEGEGKPYEGTQTMRIKVVEGGPLPFAFDILATSFLYGSKTFINHTQGIPDFFKQSFPEGFTWERVTTYEDGGVLTATQDTSLQDGCLIYNVKIRGVNFTSNGPVMQKKTLGWEAFTETLYPADGGLEGRNDMALKLVGGSHLIANIKTTYRSKKPAKNLKMPGVYYVDYRLERIKEANNETYVEQHEVAVARYCDLPSKLGHKLN*"/></Q></Feature><Feature recentID="4" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2237-2440" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1933-2236" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6841" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6050-6841" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6842-6910" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="7" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5291-5879" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3610-4197" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4271-4504" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4716-4851" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4576-4697" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6911-7015" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="4937-4943" color="#ffffff" type="standard"/><Segment range="4944-4961" color="#ffffff" type="standard"/><Segment name="-35" range="4962-4967" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4982-5003" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4913-4929" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="Factor Xa site" directionality="2" translationMW="473.53" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4080" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="3697" maxFusedRunOn="3697" visible="0" detectionMode="exactProteinMatch"><Segment range="4081-4092" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ©<Notes>
<UUID>8f0e048e-117e-4684-b528-ea21b2f9a9c2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLV3-CMV-MAP1LC3A(human)-TagBFP</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="4:36:49">2025.7.24</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             o<StrandColors><TopStrand><ColorRange range="0..2858" colors="black"/><ColorRange range="2859..2888" colors="light blue"/><ColorRange range="2889..7513" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2858" colors="black"/><ColorRange range="2859..2888" colors="light blue"/><ColorRange range="2889..7513" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
